Objective    To study the expressions of vascular endothelial growth factor (VEGF) and maspin in gastric carcinoma and their relation to the clinicopathological features.     Methods    VEGF  protein and maspin protein expression in 102 cases of human gastric carcinoma tissues and normal tissues around the foci were examined by immunohistochemical method (Envision).     Results    The overexpression rate of VEGF protein was 50.0% (51/102) in gastric carcinoma tissues and 0.0% (0/102) in normal tissues (P0.01); as for maspin

the overexpression rate of maspin protein was 52.0% (53/102) in gastric carcinoma tissues and 87.3% (89/102) in normal tissues (P0.01). The VEGF expressions were related to serosa invasion

TNM staging

lymph node metastasis and 5-year survival rate (P0.05). There was a close relation of maspin expression with serosa invasion

lymph node metastasis and 5-year survival rate (P0.05).     Conclusion    Detecting the protein levels of VEGF and maspin simultaneously in gastric carcinoma provide certain reference value in judging invasion and metastasis potential and evaluating the prognosis.