<sup>18</sup>F-FMISO在肺癌模型小鼠体内的生物分布及PET显像研究

王钰琦; 郑昕; 周乃康; 张锦明; 柳曦; 张竞

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¹⁸F-FMISO在肺癌模型小鼠体内的生物分布及PET显像研究

论著 | 更新时间：2026-01-09

- ¹⁸F-FMISO在肺癌模型小鼠体内的生物分布及PET显像研究
- Biodistribution and PET imaging of ¹⁸F-fluoromisonidazole in murine model of lung carcinoma
- 陆军军医大学学报 2007年29卷第18期页码：1794-1796
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  中图分类号： R730.44;R969.1;R981.1
- 纸质出版：2007
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王钰琦,郑昕,周乃康,张锦明,柳曦,张竞.18F-FMISO在肺癌模型小鼠体内的生物分布及PET显像研究[J].陆军军医大学学报(原第三军医大学学报),2007,29(18):1794-1796.

　WANG Yu-qi,ZHENG Xin,ZHOU Nai-kang,ZHANG Jin-ming,LIU Xi,ZHANG Jing.Biodistribution and PET imaging of 18F-fluoromisonidazole in murine model of lung carcinoma[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(18):1794-1796.
王钰琦,郑昕,周乃康,张锦明,柳曦,张竞.18F-FMISO在肺癌模型小鼠体内的生物分布及PET显像研究[J].陆军军医大学学报(原第三军医大学学报),2007,29(18):1794-1796. DOI：

　WANG Yu-qi,ZHENG Xin,ZHOU Nai-kang,ZHANG Jin-ming,LIU Xi,ZHANG Jing.Biodistribution and PET imaging of 18F-fluoromisonidazole in murine model of lung carcinoma[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(18):1794-1796. DOI：

摘要

目的评价乏氧显像剂

F-硝基咪唑丙醇（

F-FMISO）在肺腺癌动物模型中的诊断价值。方法荷肺腺癌T739小鼠经尾静脉注入

F-FMISO后不同时间（30、60、90、120 min）处死，测量

F-FMISO的生物分布，并行PET显像。对照组小鼠在注入

F-氟脱氧葡萄糖（

F-FDG）后行PET显像。结果荷瘤鼠肿瘤PET显像清晰。生物分布研究表明肿瘤有明显的放射性摄取。在肾脏和肝脏有较高的放射性分布。肿瘤对血和肌肉的T/NT比值均大于2。结论肺部恶性肿瘤组织中

F-FMISO摄取高于正常组织，可通过PET清晰显像，为进一步临床应用于肿瘤的乏氧诊断提供了依据。

Abstract

Objective To evaluate the diagnosis value of a hypoxic contrast

F-fluoromisonidazole (

F-FMISO)

in murine model of pulmonary carcinoma. Methods After the injection of

F-FMISO into the tail

48 T739 mice bearing the pulmonary adenocarcinoma were sacrificed and divided into 4 groups according different killing times (30

90 and 120 min). The biodistribution was measured and PET scanning was performed. Another 8 tumor bearing T734 mice served as control

and PET was carried out after the injection of

F-FDG. Results The tumor PET images with

F-FMISO were clear. Considerable r

adioactive uptake on tumor was observed. Higher radioactivity was found in the kidneys and liver. The T/NT ratios of tumor/muscle and tumor/blood were above 2.0. Conclusion The uptake of

F-FMISO in pulmonary malignant tissues is higher than that in normal tissues

thus the pulmonary neoplasm can be identified accurately with PET imaging. Our preliminary study provides a basis for further clinical hypoxic diagnose of the tumor.

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18F-FMISO在肺癌模型小鼠体内的生物分布及PET显像研究

Biodistribution and PET imaging of 18F-fluoromisonidazole in murine model of lung carcinoma

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摘要

Abstract

关键词

Keywords

references

¹⁸F-FMISO在肺癌模型小鼠体内的生物分布及PET显像研究

Biodistribution and PET imaging of ¹⁸F-fluoromisonidazole in murine model of lung carcinoma