Objective    To observe the expression of interferon gamma receptor on neuron and astrocyte of the hippocampus of depressed rats.      Methods    The depressed rats were produced by separation raise and unpredictable mild stressors.Their behaviors were evaluated in open-field test. The rats underwent electro-convulsive treatment (ECT) or modified electric convulsive therapy (MECT). The expression of interferon gamma receptor on neuron and astrocyte of the hippocampus was detected by immunofluorescence and in situ hybridization.      Results    There were significant differences among the stress plus ECT group

the stress plus MECT group

the stress plus sham electroshock group in all the three tests.      Conclusion    ECT and MECT can both reduce the expression of interferon gamma receptor on neuron and astrocyte of the hippocampus of depressed rats

and MECT shows more stronger therapeutic effect. Cytokine may play an important role in the pathophysiologic mechanism of depression.