Objective    To explore the transthyretin (TTR) level in obesity and its relationship with blood lipid

insulin sensitivity and β-cell function.     Methods    Somatometry and seventy-five gram oral glucose tolerance test were conducted

then blood lipid profile

free fatty acid

blood glucose

insulin and TTR were assayed. The included subjects were divided into obesity and non-obesity according to international standard.      Results    The TTR level in obesity was significantly higher than that in non-obesity[(351.9±48.6) mg/L vs (327.1±58.5)mg/L

P0.01]. There were obvious positive correlations of TTR with TG

TC

LDL

FFA

WHR

BMI (r=0.535

0.369

0.298

0.174

0.393

0.282 respectively

P0.01)

and negative correlations of TTR with HDL

HOMA-IS

DI (r=-0.24

-0.173

-0.157

P0.01). Multielement stepwise regression analysis suggested that TG

TC

WHR and age were major factors to regulate the TTR level.     Conclusion    Long-term increase of TTR is closely correlated with obesity

especially central obesity

reflecting metabolic disorder of lipid and insulin sensitivity to some extent

and being related to injury of islet β-cell function.