Objective     To explore the role of p38MAPK and TGFβ

2

in the development of diabetic retinopathy．      Methods     Fifteen Hamsters were induced into diabetic models by intraperitoneal injection of Streptozotocin (40 mg/kg once a day) for 3 d and 13 Hamsters were successfully established

whose blood glucose was over 13.5 mmol/L. Ten Hamsters as controls were intraperitoneally injected of physical saline of the same volume. At 16

th

week after induction

the total RNA of retina from all sacrificed Hamsters was collected. The mRNA expressions of p38MAPK

TGFβ

2

in retina were detected by semi-quantitative RT-PCR and their protein levels by Western blotting.      Results     The mRN

A expressions of p38MAPK

TGFβ

2

in retina were of high tendency and their protein levels increased.      Conclusion     p38MAPK signal pathway may involve in the pathogenesis of diabetic retinopathy.