Objective     To investigate the influence of experimental scotoma on multifocal visual evoked potential (mf-VEP).      Methods     The mf-VEP of 10 healthy individuals (20 eyes) was measured with VERIS Science 4.0. Every eye was measured for 3 times. The right eye was measured with full field stimulation and upper hemi-field or lower hemi-field masked. The left eye was measured with full field stimulation and central three-rings area or lower nasal field masked. The first slice responses of the second order in different field were analyzed and compared by VERIS software.      Results     The mf-VEP in masked area was undetectable or obviously decreased in all subjects. In most unmasked field

the amplitudes of mf-VEP were not changed

  except that in some  place decreased slightly with statistically significant difference in comparison to the full field stimulation mode.      Conclusion     mf-VEP is influenced with experimental scotoma. The mf-VEP changes are consistent with the visual field masked.