Objective    To analyze the disease burden of Yi nationality.     Methods    Disability adjusted life years (DALY) was used as the measurement indicator of disease burden.     Results    The male had greater Years of Life Lost to Premature Death (YLL)per thousand populations

Years of Lived with Disability (YLD) and DALY than did the female almost in each age group. The burden of Neuropsychiatric conditions was the heaviest. The burden of Yi nationality was heavier than Han nationality in diseases during perinatal period and digestive diseases. However

the disease burden of malignant neoplasm of Han nationality was heavier than Yi nationality.     Conclusion    The prevention and treatment of neuropsychiatric conditions

diseases during perinatal period and digestive diseases should be enhanced in Yi nationality.