Objective     To explore the relation between traumatic disseminated intravascular coagulation (DIC) and the level of plasma thrombomodulin (TM) in severe multiple-injury patients.      Methods     Sixty-six multiple-injury patients were divided into minor-injury group (ISS16

21cases) and severe injury group (ISS≥16

45 cases).Then the severe multiple-injury group was subdivided into DIC group (12 cases) and non-DIC group (33 cases). The other 10 healthy people served as the control group. Venous blood was collected once in the control group and in other groups venous blood was collected on day 1

3 and 7 after trauma. The TM concentration was determined by ELISA.      Results     The TM levels of the minor-injury and severe injury groups were higher than those of the control group

and the severe injury group was remarkably higher than the minor-injury group. In the non-DIC group

the TM level continuously declined; while in the DIC group

it rose at first and then decreased remarkably

with the level being remarkably higher in DIC group than  non-DIC one.      Conclusion     TM level is not only relevant to the severity of trauma

but also closely relevant to the occurrence of traumatic DIC after trauma. The detection of plasma TM level can predict the occurrence of DIC.