<sup>18</sup>F-FLT在小鼠肺癌和炎症模型中的生物分布及PET显像研究

柳曦; 周乃康; 张锦明; 梁朝阳; 张竞; 郑昕

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¹⁸F-FLT在小鼠肺癌和炎症模型中的生物分布及PET显像研究

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- ¹⁸F-FLT在小鼠肺癌和炎症模型中的生物分布及PET显像研究
- Experimental study on biodistribution and PET imaging of 3’-deoxy-3’-¹⁸F-fluorothymidine in murine models of lung carcinoma and inflammation
- 陆军军医大学学报 2007年29卷第9期页码：798-800
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  中图分类号： R734.2;R814.42;R817-33
- 纸质出版：2007
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柳曦,周乃康,张锦明,梁朝阳,张竞,郑昕.18F-FLT在小鼠肺癌和炎症模型中的生物分布及PET显像研究[J].陆军军医大学学报(原第三军医大学学报),2007,29(09):798-800.

　LIU Xi,ZHOU Nai-kang,ZHANG Jin-ming,LIANG Chao-yang,ZHANG Jing,ZHENG Xin.Experimental study on biodistribution and PET imaging of 3’-deoxy-3’-18F-fluorothymidine in murine models of lung carcinoma and inflammation[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(09):798-800.
柳曦,周乃康,张锦明,梁朝阳,张竞,郑昕.18F-FLT在小鼠肺癌和炎症模型中的生物分布及PET显像研究[J].陆军军医大学学报(原第三军医大学学报),2007,29(09):798-800. DOI：

　LIU Xi,ZHOU Nai-kang,ZHANG Jin-ming,LIANG Chao-yang,ZHANG Jing,ZHENG Xin.Experimental study on biodistribution and PET imaging of 3’-deoxy-3’-18F-fluorothymidine in murine models of lung carcinoma and inflammation[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(09):798-800. DOI：

摘要

目的研究3’-脱氧-3’-

F-氟代胸苷（

F-FLT）在肺癌模型和炎症模型的生物分布和PET显像，以评价

F-FLT 作为一种新的PET示踪剂在肺部恶性肿瘤诊断中的作用。方法 16只荷肺腺癌T739小鼠和12只T739炎症模型小鼠均根据不同示踪剂[

F-FLT和

F-氟代脱氧葡萄糖（

F-FDG）

]

被随机分为两组，在经尾静脉注药后60 min用井型探测仪测量小鼠

F-FLT和

F-FDG的生物分布，并行PET显像。结果在肺癌模型

F-FLT的生物分布研究中，发现肿瘤部位有较高的放射性摄取，肿瘤对血、肌肉及肺的T/NT比值均大于2。应用

F-FLT和

F-FDG的肿瘤PET显像均非常清晰。在炎症模型的研究中，

F-FDG组炎性组织对肌肉的放射性比值(2.25±0.39)明显高于

F-FLT组(1.26±0.19)（P0.01）。炎性组织摄取

F-FDG而不摄取

F-FLT。结论肺部恶性肿瘤组织中

F-FLT摄取高于正常组织。炎性组织在

F-FLT PET扫描中未见显像，表明

F-FLT在两种疾病模型的鉴别中有特异性。

Abstract

Objective To investigate the biodistribution and positron emission tomography (PET) imaging of 3′-deoxy-3′-

F-fluorothymidine (

F-FLT) in murine models of lung carcinoma and inflammation

so as to evaluate the use of

F-FLT as a new PET tracer for diagnosis of

malignant tumor. Methods Sixteen T739 mice bearing the lung adenocarcinoma were randomly divided into two groups according to the different tracers. The biodistribution of mice for

F-FLT and

F-fluorodeoxyglucose (

F-FDG) was measured with well-gamma detector at 60 min after injection from tail veins. PET imaging was performed using two tracers. The whole process mentioned above was repeated in twelve T739 mice with inflammation. Results In the biodistribution study of

F-FLT with lung carcinoma models

considerable radioactive uptake by tumor was observed. The ratios of tumor/blood

tumor/muscle and tumor/lung were all above 2.0. The tumor PET images with

F-FLT and

F-FDG were clear. In the study with inflammation models

inflammation-to-muscle radioactivity ratio of

F-FDG (2.25±0.39) were higher than that of

F-FLT (1.26±0.19) (P0.01).

F-FDG accumulated in inflammatory tissues

whereas

F-FLT was not taken up by these tissues. Conclusion The uptake of

F-FLT in pulmonary malignant tissues is higher than that in normal tissues. Inflammatory tissues are invisible in

F-FLT PET images.

F-FLT is of good specificity to differentiate the two models.

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18F-FLT在小鼠肺癌和炎症模型中的生物分布及PET显像研究

Experimental study on biodistribution and PET imaging of 3’-deoxy-3’-18F-fluorothymidine in murine models of lung carcinoma and inflammation

DOI：

摘要

Abstract

关键词

Keywords

references

¹⁸F-FLT在小鼠肺癌和炎症模型中的生物分布及PET显像研究

Experimental study on biodistribution and PET imaging of 3’-deoxy-3’-¹⁸F-fluorothymidine in murine models of lung carcinoma and inflammation