Objective     To explore the effect of astragalus polysaccharides (APS) and soy isoflavones (SI) on glucose metabolism in diabetic rats.      Methods     Healthy 60 rats were equally and randomly divided into 5 groups

normal forage group (NF)

high blood sugar model group(HBS)

APS high dose group intervention group (APS-H)

APS low dose group (APS-L)

and SI intervention group (SI). Diabetic model was inflicted by intraperitoneal injection of streptozotocin (STZ). Ordinary feed and APS high dose，low dose APS and SI interfere were respectively given for 8 weeks. Blood glucose，glycated hemoglobin，glucose and lipid levels were determined in every group.      Results     After APS high dose，low dose and SI were given to feed diabetic rats for 8 weeks

their blood glucose

glycated hemoglobin

glucose

TC

TG

LDL

VLDL and high blood glucose was significantly lower than the HBS group (P0.05)

and their HDL was significantly higher than the HBS group (P0.05).      Conclusion     APS and SI both exert the effect of reducing blood sugar and blood fats

and may be used to prevent diabetes and its complication.