Objective     To investigate the serum level of adipocytokines before and after the treatment of Clearing Liver and Purging the Heart Decoction in type 2 diabetes patients

and to explore the relationship between serum adipocytokine concentrations with insulin resistance.      Methods     Sixty patients of type 2 diabetes were randomly divided into treated group (30 cases) and control group (30 cases).The treated group were treated with Clearing Liver and Purging the Heart Decoction for 2 months

and the control were given with rosiglitazone mesylate (Avandia

4 mg/d) for 2 months. Their serum levels of adiponectin and resistin before and after the treatment were measured with ELISA method. Their T-Cho

TG

HDL-C

LDL-C

blood sugar

C-P levels as well as insulin resistance levels were measured.      Results     The levels of T-Cho and TG

in the 2 groups were decreased

but no significant difference was observed between the before and after treatment or between the 2 groups. Levels of HDL-C and LDL-C were significantly increased and reduced respectively in 2 groups after than before treatment (P0.05)

and blood sugar was reduced in 2 groups (P0.01)

but no significant difference was observed in these 3 indexes between the 2 groups. HbA1c was reduced too in 2 groups (P0.01)

with the treated groups more significant (P0.01). Levels of FINS and C-P were significantly reduced in 2 groups (P0.01)

and IAI was increased

but no significant difference was observed between the 2 groups. After treatment

serum levels of resistin was reduced and adiponectin was increased in 2 groups (P0.01)

no significant difference was observed between the 2 groups.      Conclusion      Serum level of resistin is decreased and that of adiponectin increased after treatment of the Clearing Liver and Purging the Heart Decoction or avandia. All these changes of adipocytokine are well correlated with insulin resistance.