Objective    To investigate the influence of a novel isoflavone compound

F11

on femoral biomechanics of ovarectomied rats.     Methods    The ovarectomied rat models were randomly assigned to five groups: control

sham operation

and three experimental groups in which F11 of  different concentrations were intraperitoneally injected once a day for ten weeks. Ten weeks later

all rats were killed and the left femurs harvested to determine the bony biomechanic and histology.     Results    The maximal load

flexibility load

and elastic modulus in F11 groups were remarkably enhanced as compared with sham operation group and control group. Osteoporosis at the epiphysis

trabecular alignment derangement and sparseness were seen in ovarectomied rats

but the changes were substantially mild in F11 groups.     Conclusion    F11 can enhance the ability of the femur to resist the impact of external force in ovarectomied rats

improve bony tenacity

and as a result will reduce the dangers of bone fracture.