Objective     To investigate the correlation between bacterial cryptic growth cell (CGC) and irritable bowel syndrome（IBS）.      Methods     The techniques of micro-culture and morphological observation were employed in examination of the CGC in feces specimens of patients suffering from IBS. Furthermore

the animal monitoring tests was applied in the aspects of CGC formation under inducing factors and colonization at local intestinal mucus.      Results     A great deal of CGC could be observed in the feces of IBS patients and exhibited continuous proliferation characteristics regardless of using or not using antibiotics. And the CGC in feces showed auto-lysis features when the patients suffered from the disease. The monitoring tests demonstrated that the antibiotics often used presently to IBS patients could induce the formation and colonization of intestinal bacterial CGC.      Conclusion     Based on the experimental and clinical data

we presume that there is a correlation between intestinal bacterial CGC and IBS.