Objective    To observe the protective effect of edaraven on brain tissue and the therapeutic mechanism in rats following intracerebral hemorrhage(ICH).      Methods    In this series

96 Sprague-Dawley rats were divided into three groups at random(n=32 in each group)： sham-operative group

ICH model group and edaraven therapy group.  ICH model was induced by infusion of autologous whole blood into the caudate-putamen. Rats in sham-operative group were treated the same as above

but no blood injected. Rats in edaraven therapy group were treated with edaraven (3 mg/kg) by peritoneal injection 30 min before operation and once per 12 hours after operation. These rats were killed at 6

24

72

and 168 h after neurologic impairment test with Longa criteria. Brain water content was measured by dry-wet weight method. Malondialdehyde and TNF-alpha in the vicinity of the hematoma were measured by thio-barbituric acid method and ELISA respectively.      Results    Compared with sham operative group

neurologic impairment score

brain water content

malondialdehyde and TNF-alpha in brain tissues were obviously higher in ICH model group (P0.05). Compared with ICH model group

neurologic impairment score

brain water content

malondialdehyde and TNF-alpha in brain tissues were significantly decreased in edaraven therapy group (P0.05).      Conclusion    Edaraven has an evident protective effect on injured brain tissue through inhibiting malondialdehyde and TNF-alpha content in the vicinity of the hematoma.