Objective    To investigate the influence of hypoxia on leptin expression in serum

CSF and brain tissue of C57BL/6J mice.     Methods    C57BL/6J mice were divided into 3 groups: the normal control

24-hour hypoxia group and 48-hour hypoxia group. The latter two groups exposed to hypoxia in the man-made auto pressure and hypoxia control cabin (XQ-I). Radioimmunoassay was used to detect the leptin level.     Results    The leptin level in the serum

CSF and brain tissue of mice exposed to hypoxia were higher than that of normal control

but no difference was found between 24-hour hypoxia group and 48-hour hypoxia group.     Conclusion    Hypoxia probably induces the increasing of leptin expression in fat tissue

as well as in the central nervous system.