Objective     To study the effects of Senqi Fuzheng injection on the apoptosis of myocardial cells and the expressions of Bcl-2 and Bax in experimental rabbits with myocardial contusion (MC).      Methods     Totally 50 healthy rabbits were randomized into 4 groups: reference group (n=20)

control group (n=10)

Sen group (n=10) and MC group (n=10). MC model was inflicted with aid of BIM-Ⅱbiomedical impact-machine. The apoptosis of myocardial cells was analyzed by TUNEL. The expressions of Bcl-2 and Bax were detected by using immunohistochemistry with SABC method. The rate of apoptosis in myocardial cells was quantified with flow cytometry. Control group was treated similar to the MC group except the impact.      Results     The levels of serum cTnI were significantly increased 4 h after impact in MC and Sen group (P0.05). Myocardial cell apoptosis was only detected in MC and Sen group

with the apoptosis index (AI) of (15.686 0±0.688 7)% and (5.579 0±0.191 7)% respectively (P0.05). The rate of apoptosis was (6.932 0±0.638 0) % in MC group and（3.021 0±0.254 0）% in Sen group (P0. 05). Bcl-2 expression was up-regulated while Bax expression was down-regulated in Sen group compared to those in MC group (P0.05).      Conclusion     Senqi Fuzheng injection can lower the AI and protect myocardial cells from MC by increasing Bcl-2 expression and decreasing Bax expression.