YAN Ren-qing,LUO Jun-min,SUN Wan-bang,QI Ying.Changes of peripheral blood dendritic cell subgroup in pulmonary tuberculosis patients[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(13):1298-1300.
YAN Ren-qing,LUO Jun-min,SUN Wan-bang,QI Ying.Changes of peripheral blood dendritic cell subgroup in pulmonary tuberculosis patients[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(13):1298-1300.DOI:
Objective To observe the changes of peripheral blood dendritic cell (DC) subgroup in amount in pulmonary tuberculosis patients. Methods DC1 and DC2 subgroups were detected in peripheral blood of 70 pulmonary tuberculosis patients by tricolor analytic method of flow cytometry. Results In active stage of pulmonary tuberculosis
DC1/PBMC
DC2/PBMC and the absolute quantity of DC1
DC2 in peripheral blood were significantly lower than healthy subjects (P0.05) and DC1/DC2 ratio was significantly higher (P0.05). In inactive stage of pulmonary tuberculosis
DC1/PBMC
DC2/PBMC and the absolute quantity of DC1
DC2
DC1/DC2 ratio in peripheral blood showed no significant difference with that of healthy subjects (P0.05); The absolute quantity of DC2 in active stage of pulmonary tuberculosis was obviously lower than that in inactive stage (P0.05). Conclusion The percentage and the absolute quantity of DC1 and DC2 subgroups in peripheral blood in active stage of pulmonary tuberculosis are lower than the healthy subjects
suggesting DC can reflect the immune function of pulmonary tuberculosis patients
the patients’ condition and illuminate the immunopathogenesis of pulmonary tuberculosis.