Correlation between early seizures in patients with cerebral venous sinus thrombosis and serum D-dimer level

Yin Ge; Sun Rui; Gao Xin; Fan Cunxiu; Chai Changfeng; Bi Xiaoying

doi:DOI：10.13406/j.cnki.cyxb.003066

您当前的位置：

首页 >

文章列表页 >

Correlation between early seizures in patients with cerebral venous sinus thrombosis and serum D-dimer level

CerebrovascularDiseaseResearch | 更新时间：2025-10-21

- Correlation between early seizures in patients with cerebral venous sinus thrombosis and serum D-dimer level
- Journal of Chongqing Medical University Vol. 47, Issue 7, Pages: 768-772(2022)
- 作者机构：
  
  海军军医大学第一附属医院神经内科，上海 200433
- 作者简介：
- 基金信息：
- DOI：DOI：10.13406/j.cnki.cyxb.003066
  CLC： R743
- Received：29 April 2022，
  
  Published：28 July 2022
- 稿件说明：
移动端阅览
殷歌,孙瑞,高昕,等.脑静脉窦血栓形成患者早期癫痫发作与血清D-二聚体相关性的研究[J].重庆医科大学学报,2022,47(7):768-772.

Yin Ge,Sun Rui,Gao Xin,et al.Correlation between early seizures in patients with cerebral venous sinus thrombosis and serum D-dimer level[J].Journal of Chongqing Medical University,2022,47(7):768-772.
殷歌,孙瑞,高昕,等.脑静脉窦血栓形成患者早期癫痫发作与血清D-二聚体相关性的研究[J].重庆医科大学学报,2022,47(7):768-772. DOI： DOI：10.13406/j.cnki.cyxb.003066.

Yin Ge,Sun Rui,Gao Xin,et al.Correlation between early seizures in patients with cerebral venous sinus thrombosis and serum D-dimer level[J].Journal of Chongqing Medical University,2022,47(7):768-772. DOI： DOI：10.13406/j.cnki.cyxb.003066.

摘要

目的

探讨脑静脉窦血栓形成（cerebral venous sinus thrombosis，CVST）患者早期癫痫发作与血清D-二聚体水平的相关性及对预后的影响。

方法

回顾2010年11月至2021年3月在海军军医大学第一附属医院神经内科及脑血管病中心住院的CVST患者，收集患者一般情况、CVST诊疗情况及相关血液学指标等资料。根据患者有无早期癫痫发作将其分为2组，对2组间指标进行差异分析，并通过logistic回归分析研究早期癫痫发作的影响因素；通过改良Rankin量表（modified Rankin scale，mRS）评分将患者分为预后良好组及预后不良组，分析血清D-二聚体水平与CVST患者预后的关系。

结果

共纳入CVST患者60例，其中有癫痫发作组22例（36.7%），无癫痫发作组38例。比较2组患者基线资料及血液学指标情况发现，有癫痫发作组mRS评分和D-二聚体水平明显高于无癫痫发作组；logistic回归分析结果显示血清D-二聚体水平是CVST早期癫痫发作的危险因素（

=1.513，95%CI

1.022～2.241，

=0.039）；早期癫痫发作与CVST患者预后不良相关，而治疗前后血清D-二聚体水平及其下降幅度均与疾病预后无明显相关。

结论

血清高D-二聚体水平和CVST患者早期癫痫发作有关，早期癫痫发作影响CVST患者预后，因此对入院时血清D-二聚体升高的CVST患者应尽早干预，有望预防早期癫痫发作来改善患者预后。

Abstract

Objective

To investigate the relationship between early seizures in patients with cerebral venous sinus thrombosis（CVST）and the serum D-dimer level，and discuss the effects on the prognosis.

Methods

The CVST patients who were treated in the wards of Neurological and Cerebrovascular Departments of The First Affiliated Hospital of Naval Medical University from November 2010 to March 2021 were reviewed，and the general information，diagnosis and treatment of CVST and related hematological indicators of the patients were collected. Then the patients were divided into two groups according to the presence or absence of early seizures，the differences of related indicators between the two groups were analyzed，and the influencing factors of early seizures were studied by logistic regression analysis. The patients were divided into good and poor prognosis group by modified Rankin scale（mRS） score，and the relationship between serum D-dimer level and prognosis of CVST patients was analyzed.

Results

A total of 60 patients with CVST were included，including 22（36.7%） with seizure and 38 without seizure. The results of comparing the baseline data and hematological indexes of the two groups showed that mRS score and D-dimer level in the seizure group were significantly higher than those in the non-seizure group，and the incidence of poor prognosis was significantly higher than that of the non-seizure group； logistic regression analysis showed that D-dimer level might be a risk factor for early seizures in CVST（

=1.513，95%CI=1.022-2.241，

=0.039）；early seizures were related to the poor prognosis of CVST patients，and serum D-dimer level before and after treatment and its decreasing range were not significantly related to disease prognosis.

Conclusion

High serum D-dimer levels are associated with early seizures in CVST，and early seizures affect the prognosis of CVST patients. Therefore，early intervention in CVST patients with elevated serum D-dimer on admission is expected to prevent early seizures and improve outcomes of CVST patients.

关键词

Keywords

references

Saposnik G ， Barinagarrementeria F ， Jr Brown RD ， et al . Diagnosis and management of cerebral venous thrombosis：a statement for healthcare professionals from the American Heart Association/American Stroke Association [J ] . Stroke ， 2011 ， 42 （ 4 ）： 1158 - 1192 .

Hartel M ， Kluczewska E ， Gancarczyk-Urlik E ， et al . Cerebral venous sinus thrombosis [J ] . Phlebology ， 2015 ， 30 （ 1 ）： 3 - 10 .

Janghorbani M ， Zare M ， Saadatnia M ， et al . Cerebral vein and dural sinus thrombosis in adults in Isfahan，Iran：frequency and seasonal variation [J ] . Acta Neurol Scand ， 2008 ， 117 （ 2 ）： 117 - 121 .

Conrad J ， Pawlowski M ， Dogan M ， et al . Seizures after cerebrovascular events：risk factors and clinical features [J ] . Seizure ， 2013 ， 22 （ 4 ）： 275 - 282 .

Ferro JM ， Correia M ， Rosas MJ ， et al . Seizures in cerebral vein and dural sinus thrombosis [J ] . Cerebrovasc Dis ， 2003 ， 15 （ 1/2 ）： 78 - 83 .

Davoudi V ， Keyhanian K ， Saadatnia M . Risk factors for remote seizure development in patients with cerebral vein and dural sinus thrombosis [J ] . Seizure ， 2014 ， 23 （ 2 ）： 135 - 139 .

Masuhr F ， Busch M ， Amberger N ， et al . Risk and predictors of early epileptic seizures in acute cerebral venous and sinus thrombosis [J ] . Eur J Neurol ， 2006 ， 13 （ 8 ）： 852 - 856 .

Price M ， Günther A ， Kwan JS . Antiepileptic drugs for the primary and secondary prevention of seizures after intracranial venous thrombosis [J ] . Cochrane Database Syst Rev ， 2014 ， 8 ： CD005501 .

中华医学会神经病学分会，中华医学会神经病学分会脑血管病学组 . 中国颅内静脉血栓形成诊断和治疗指南2019 [J ] . 中华神经科杂志， 2020 ， 53 （ 9 ）： 641 - 643 .

Chinese Society of Neurology , Cerebrovascular Disease Group of Chinese Society of Neurology ， Chinese guidelines for diagnosis and treatment of cerebral venous thrombosis 2019 [J ] . Chin J Neurol ， 2020 ， 53 （ 9 ）： 641 - 643 .

Kalita J ， Singh VK ， Jain N ， et al . Cerebral venous sinus thrombosis score and its correlation with clinical and MRI findings [J ] . J Stroke Cerebrovasc Dis ， 2019 ， 28 （ 11 ）： 104324 .

Gazioglu S ， Yildirim A ， Kokturk EG ， et al . Acute seizures in cerebral venous sinus thrombosis：risk factors and prognosis [J ] . Neurologist ， 2020 ， 25 （ 5 ）： 126 - 130 .

Ferro JM ， Canhão P ， Stam J ， et al . Prognosis of cerebral vein and dural sinus thrombosis：results of the International Study on Cerebral Vein and Dural Sinus Thrombosis（ISCVT） [J ] . Stroke ， 2004 ， 35 （ 3 ）： 664 - 670 .

Sha DJ ， Qian J ， Gu SS ， et al . Cerebral venous sinus thrombosis complicated by seizures：a retrospective analysis of 69 cases [J ] . J Thromb Thrombolysis ， 2018 ， 45 （ 1 ）： 186 - 191 .

Ferro JM ， Canhão P ， Bousser MG ， et al . Early seizures in cerebral vein and dural sinus thrombosis：risk factors and role of antiepileptics [J ] . Stroke ， 2008 ， 39 （ 4 ）： 1152 - 1158 .

Meng R ， Li ZY ， Ji XM ， et al . Antithrombin Ⅲ associated with fibrinogen predicts the risk of cerebral ischemic stroke [J ] . Clin Neurol Neurosurg ， 2011 ， 113 （ 5 ）： 380 - 386 .

Meng R ， Ji XM ， Li BY ， et al . Dynamical levels of plasma F（1+2）and D-dimer in patients with acute cerebral infarction during intravenous urokinase thrombolysis [J ] . Neurol Res ， 2009 ， 31 （ 4 ）： 367 - 370 .

Meng R ， Wang XY ， Hussain M ， et al . Evaluation of plasma D-dimer plus fibrinogen in predicting acute CVST [J ] . Int J Stroke ， 2014 ， 9 （ 2 ）： 166 - 173 .

Mahale R ， Mehta A ， John AA ， et al . Acute seizures in cerebral venous sinus thrombosis：what predicts it? [J ] . Epilepsy Res ， 2016 ， 123 ： 1 - 5 .

Li H ， Cui LQ ， Chen ZY ， et al . Risk factors for early-onset seizures in patients with cerebral venous sinus thrombosis：a Meta-analysis of observational studies [J ] . Seizure ， 2019 ， 72 ： 33 - 39 .

Onder H . Cerebral venous sinus thrombosis complicated by seizures [J ] . J Thromb Thrombolysis ， 2018 ， 46 （ 1 ）： 77 - 78 .

Mehvari Habibabadi J ， Saadatnia M ， Tabrizi N . Seizure in cerebral venous and sinus thrombosis [J ] . Epilepsia Open ， 2018 ， 3 （ 3 ）： 316 - 322 .

Sato T ， Sato S ， Yamagami H ， et al . D-dimer level and outcome of minor ischemic stroke with large vessel occlusion [J ] . J Neurol Sci ， 2020 ， 413 ： 116814 .

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effect of circulating plasma cell on the prognosis of patients with multiple myeloma

Prognostic study of ¹⁸F-FDG PET/CT combined with clinical characteristics in treated patients with esophageal squamous cell carcinoma

Association between albumin-corrected anion gap and prognosis in patients with acute pancreatitis: a retrospective cohort study

Role of chloride ions in the prognosis of patients with decompensated cirrhosis

Association of miR-296-5p，S-phase kinase-associated protein 2， and ribosomal protein L6 with the pathological features of prostate cancer and their influence on surgical prognosis

Related Author

Li Miaoyu

Wang Lulu

Tian Biao

Xiao Wanting

Weng Yanxia

Sun Wenrui

Tang Hailong

Gao Guangxun

Related Institution

Department of Hematology，the First Affiliated Hospital of Air Force Medical University

Department of Nuclear Medicine，The First Affiliated Hospital of Chongqing Medical University

Department of Critical Care Medicine，The Seventh People’s Hospital，Shanghai University of Traditional Chinese Medicine

Graduate School，Tianjin University of Traditional Chinese Medicine

Department of Respiratory and Critical Care Medicine，The First Affiliated Hospital of Xi’an Jiaotong University

⁰