Effects of ω-3 polyunsaturated fatty acid combined with clomiphene on clinical efficacy， pregnancy and safety in patients with polycystic ovary syndrome

HU Hailing; ZHOU Qiongjiao; XIE Dan; CAI Yu

doi:10.6039/j.issn.1001-0408.2026.09.14

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Effects of ω-3 polyunsaturated fatty acid combined with clomiphene on clinical efficacy， pregnancy and safety in patients with polycystic ovary syndrome

更新时间：2026-05-14

- Effects of ω-3 polyunsaturated fatty acid combined with clomiphene on clinical efficacy， pregnancy and safety in patients with polycystic ovary syndrome
- ZHONGGUO YAOFANG Vol. 37, Issue 9, Pages: 1190-1194(2026)
- 作者机构：
  
  1.湖南省职业病防治院妇产科，长沙　410007
  2.长沙市第四医院妇产科，长沙　410006
  3.湖南省中西医结合医院妇科，长沙　410006
- 作者简介：
- 基金信息：
- DOI：10.6039/j.issn.1001-0408.2026.09.14
  CLC： R969.4;R711.75
- Received：21 January 2026，
  
  Revised：2026-04-20，
  
  Accepted：20 April 2026，
  
  Published：15 May 2026
- 稿件说明：
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胡海玲,周琼姣,谢丹,等.ω-3多不饱和脂肪酸联合氯米芬对多囊卵巢综合征患者疗效、妊娠和安全性的影响 [J].中国药房,2026,37(09):1190-1194.

HU Hailing,ZHOU Qiongjiao,XIE Dan,et al.Effects of ω-3 polyunsaturated fatty acid combined with clomiphene on clinical efficacy， pregnancy and safety in patients with polycystic ovary syndrome[J].ZHONGGUO YAOFANG,2026,37(09):1190-1194.
胡海玲,周琼姣,谢丹,等.ω-3多不饱和脂肪酸联合氯米芬对多囊卵巢综合征患者疗效、妊娠和安全性的影响 [J].中国药房,2026,37(09):1190-1194. DOI： 10.6039/j.issn.1001-0408.2026.09.14.

HU Hailing,ZHOU Qiongjiao,XIE Dan,et al.Effects of ω-3 polyunsaturated fatty acid combined with clomiphene on clinical efficacy， pregnancy and safety in patients with polycystic ovary syndrome[J].ZHONGGUO YAOFANG,2026,37(09):1190-1194. DOI： 10.6039/j.issn.1001-0408.2026.09.14.

摘要

目的

探讨ω-3多不饱和脂肪酸（ω-3PUFA）联合氯米芬对多囊卵巢综合征（PCOS）患者临床疗效、妊娠和安全性的影响。

方法

采用回顾性研究方法，纳入2022年1月至2023年12月在湖南省职业病防治院妇产科接受治疗的PCOS患者112例，根据不同干预方案分为单药治疗组（60例）和联合用药组（52例）。单药治疗组患者给予氯米芬治疗，联合用药组患者在氯米芬基础上联合ω-3PUFA干预。比较两组患者的临床疗效、妊娠情况、不良反应发生情况以及治疗前后卵巢功能和氧化应激指标。

结果

联合用药组患者的总有效率（90.38% vs. 71.67%）、排卵率（84.62% vs. 61.67%）、妊娠率（51.92% vs. 26.67%）均显著高于单药治疗组（

＜0.05）。治疗前，两组患者各项卵巢功能和氧化应激指标比较，差异均无统计学意义（

＞0.05）；相较于治疗前，两组患者治疗12周后的血清抗米勒管激素水平、抑制素B浓度和囊性卵泡数均显著降低或减少（

＜0.05），子宫内膜厚度均显著增加（

＜0.05），血清丙二醛和晚期氧化蛋白产物水平均显著降低（

＜0.05），血清超氧化物歧化酶和谷胱甘肽过氧化物酶活性均显著升高（

＜0.05），其中联合用药组的改善幅度均显著大于单药治疗组（

＜0.05）；两组患者治疗后的卵巢体积均显著小于治疗前（

＜0.05），但组间比较差异无统计学意义（

＞0.05）。两组患者治疗期间不良反应总发生率比较，差异无统计学意义（

＞0.05）。

结论

ω-3PUFA联合氯米芬治疗PCOS的疗效确切，可有效减轻机体氧化应激反应，改善卵巢功能，提高排卵率及妊娠率。

Abstract

OBJECTIVE

To investigate the effects of ω-3 polyunsaturated fatty acid （ω-3PUFA） combined with clomiphene on clinical efficacy， pregnancy and safety in patients with polycystic ovary syndrome （PCOS）.

METHODS

A retrospective analysis was performed on the clinical data of 112 PCOS patients who received treatment in Dept. of Obstetrics and Gynecology of Hunan Prevention and Treatment Institute for Occupational Diseases from January 2022 to December 2023. According to the different treatment regimens， the patients were divided into single-drug group （60 cases） and drug-combination group （52 cases）. Single-drug group was given clomiphene orally， and drug-combination group was given clomiphene+ω-3PUFA. Clinical efficacy， pregnancy status and the occurrence of adverse drug reaction （ADR） as well as ovarian function and oxidative stress indexes before and after treatment were compared between 2 groups.

RESULTS

The overall response rate （90.38% vs. 71.67%）， ovulation rate （84.62% vs. 61.67%）， and pregnancy rate （51.92% vs. 26.67%） were all markedly higher in drug combination group than single drug group （

＜0.05）. Before treatment， there was no statistical significance in ovarian function and oxidative stress indexes between 2 groups （

＞0.05）. Compared with before treatment， serum anti-Müllerian hormone levels， inhibin B concentr

ations， and the number of cystic follicles in 2 groups were decreased significantly after 12 weeks of treatment （

＜0.05）. The endometrial thickness increased significantly （

＜0.05）， while the serum levels of malondialdehyde and advanced oxidation protein products decreased significantly （

＜0.05）； the activities of serum superoxide dismutase and glutathione peroxidase increased significantly （

＜0.05）； the improvement of drug combination group was significantly better than single drug group （

＜0.05）. The ovarian volumes in both groups were significantly smaller after treatment compared to before treatment （

＜0.05）， but there was no statistically significant difference between the two groups （

＞0.05）. There was no significant difference in the overall incidence of ADR between the two groups during the treatment （

＞0.05）.

CONCLUSIONS

The combination of ω-3PUFA and clomiphene has a definite therapeutic effect on PCOS， which can effectively reduce the body’s oxidative stress response， improve ovarian function， and increase ovulation and pregnancy rates.

关键词

Keywords

references

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