Analysis of components absorbed into blood and brain of <italic style="font-style: italic">Lithocarpus litseifolius</italic> leaves

LIU Huan; YI Zirong; HUANG Ting; LIU Xiuhong; YE Yunyao; MA Yuming; HU Mengqi; ZHANG Nan; YANG Wenhao; LIU Yang; WANG Guopeng

doi:10.6039/j.issn.1001-0408.2026.07.11

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Analysis of components absorbed into blood and brain of Lithocarpus litseifolius leaves

更新时间：2026-07-16

- Analysis of components absorbed into blood and brain of Lithocarpus litseifolius leaves
- ZHONGGUO YAOFANG Vol. 37, Issue 7, Pages: 889-894(2026)
- 作者机构：
  
  1.北京中医药大学中药学院，北京;102488
  2.中财瀚熙（北京）生物科技发展有限公司，北京　101500
- 作者简介：
- 基金信息：
- DOI：10.6039/j.issn.1001-0408.2026.07.11
  CLC： R917
- Received：05 December 2025，
  
  Revised：2026-03-13，
  
  Accepted：13 March 2026，
  
  Published：15 April 2026
- 稿件说明：
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刘欢,易紫容,黄婷,等.木姜叶柯叶的入血及入脑成分分析 [J].中国药房,2026,37(07):889-894.

LIU Huan,YI Zirong,HUANG Ting,et al.Analysis of components absorbed into blood and brain of Lithocarpus litseifolius leaves[J].ZHONGGUO YAOFANG,2026,37(07):889-894.
刘欢,易紫容,黄婷,等.木姜叶柯叶的入血及入脑成分分析 [J].中国药房,2026,37(07):889-894. DOI： 10.6039/j.issn.1001-0408.2026.07.11.

LIU Huan,YI Zirong,HUANG Ting,et al.Analysis of components absorbed into blood and brain of Lithocarpus litseifolius leaves[J].ZHONGGUO YAOFANG,2026,37(07):889-894. DOI： 10.6039/j.issn.1001-0408.2026.07.11.

摘要

目的

分析木姜叶柯叶的入血、入脑成分，为明确其防治中枢神经系统疾病的药效物质基础提供参考。

方法

制备木姜叶柯叶醇提物以及灌胃液、灌流液。以大鼠为研究对象，通过在体肠灌流法和封闭肠环法制备肠壁代谢、肠道菌代谢、肝代谢全血样本，通过灌胃给药方法制备综合代谢全血样本和脑组织、脑脊液样本。采用超高效液相色谱-高分辨质谱技术，分析鉴定木姜叶柯叶的化学成分及其在大鼠体内的入血及入脑成分。

结果

从木姜叶柯叶中共鉴定出66个化学成分，主要为黄酮类、有机酸等。从肠壁代谢、肠道菌代谢、肝代谢与综合代谢全血样本中分别鉴定出16、13、11、5个原型成分，从脑组织样本中鉴定出4个原型成分，从脑脊液样本中鉴定出9个原型成分，其中根皮苷、三叶苷、根皮素-2-

-丙二酰己糖苷、根皮素为各样本的共有成分。

结论

木姜叶柯叶入血、入脑原型成分中的根皮苷、三叶苷、根皮素等可能是其治疗中枢神经系统疾病的药效物质基础。

Abstract

OBJECTIVE

To analyze the prototype components absorbed into blood and brain of

Lithocarpus litseifolius

leaves， so as to provide a reference for clarifying the pharmacological material basis of its prevention and treatment of central nervous system dis

eases.

METHODS

The ethanol extract of

L. litseifolius

leaves， as well as the gastric lavage fluid and perfusion solution were prepared. Using rats as subjects， plasma samples of intestinal wall metabolism， intestinal flora metabolism and hepatic metabolism were prepared via

in situ

intestinal perfusion and closed intestinal loop method； while comprehensive metabolic plasma samples， brain tissue samples， and cerebrospinal fluid samples were collected after intragastric administration. UPLC-HRMS technology was utilized to analyze and identify chemical components and prototype components absorbed into blood and brain of

L. litseifolius

leaves.

RESULTS

A total of 66 chemical constituents were identified in

L. litseifolius

leaves， primarily consisting of flavonoids， organic acids， and others. A total of 16， 13， 11， and 5 prototype components were identified in intestinal wall metabolism， intestinal flora metabolism， hepatic metabolism， and comprehensive metabolic plasma samples， respectively. Additionally， 4 prototype components were detected in brain tissue and 9 in cerebrospinal fluid. Phloridzin， trilobatin， phloretin-2-

-malonyl hexoside， and phloretin were identified as common components across all sample types.

CONCLUSIONS

Prototype components absorbed into blood and brain of

L. litseifolius

leaves，

such as phloridzin， trilobatin， phloretin， and other components may serve as the pharmacological material basis for their therapeutic effects on central nervous system diseases.

关键词

Keywords

references

中国科学院中国植物志编辑委员会 . 中国植物志：第二十二卷 [M ] . 北京：科学出版社， 1998 ： 201 .

林协全，汪其双，覃兴化，等 . 甜茶“木姜叶柯”本草考证 [J ] . 福建农林大学学报（自然科学版）， 2023 ， 52 （ 6 ）： 785 - 792 .

《全国中草药汇编》编写组 . 全国中草药汇编：下册 [M ] . 2版 . 北京：人民卫生出版社， 1996 ： 247 .

XU J F ， ZHANG F F ， LI H H ， et al . Total water-soluble flavonoids from Lithocarpus litseifolius （Hance） Chun （sweet tea） improve glucose homeostasis through multitarget signaling in GDM mice [J ] . J Diabetes Res ， 2024 ， 2024 ： 1518080 .

WANG Y K ， HU S Y ， XIAO F Y ， et al . Dihydrochalcones in sweet tea：biosynthesis，distribution and neuroprotection function [J ] . Molecules ， 2022 ， 27 （ 24 ）： 8794 .

HE X Q ， LIU D ， LIU H Y ， et al . Prevention of ulcerative colitis in mice by sweet tea （ Lithocarpus litseifolius ） via the regulation of gut microbiota and butyric-acid-mediated anti-inflammatory signaling [J ] . Nutrients ， 2022 ， 14 （ 11 ）： 2208 .

宋针珍 . 基于Nrf2/GPX4通路探究木姜叶柯叶通过调控铁死亡改善非酒精性脂肪性肝病的作用机制 [D ] . 南昌：江西中医药大学， 2024 .

刘鸿基，曾琛悦，曾霞，等 . 甜茶木姜叶柯及其主要活性成分三叶苷药理作用研究进展 [J ] . 广东药科大学学报， 2024 ， 40 （ 3 ）： 129 - 135 .

GAO J M ， ZHANG X ， SHU G T ， et al . Trilobatin rescues cognitive impairment of Alzheimer’s disease by targeting HMGB1 through mediating SIRT3/SOD2 signaling pathway [J ] . Acta Pharmacol Sin ， 2022 ， 43 （ 10 ）： 2482 - 2494 .

FENG L Y ， LI Y L ， LIN M ， et al . Trilobatin attenuates cerebral ischaemia/reperfusion-induced blood-brain barrier dysfunction by targeting matrix metalloproteinase 9：the legend of a food additive [J ] . Br J Pharmacol ， 2024 ， 181 （ 7 ）： 1005 - 1027 .

ZHANG G J ， YANG G Q ， LIU J . Phloretin attenuates behavior deficits and neuroinflammatory response in MPTP induced Parkinson’s disease in mice [J ] . Life Sci ， 2019 ， 232 ： 116600 .

刘洋，潘艳丽，王晶娟，等 . 多成分药物代谢理论及技术方法分析 [J ] . 中草药， 2014 ， 45 （ 12 ）： 1663 - 1667 .

刘洋，翟华强，赵保胜，等 . 多成分药物代谢学术思想在中医临床药学研究中的应用分析 [J ] . 中国中药杂志， 2014 ， 39 （ 7 ）： 1335 - 1338 .

KAMDI S P ， RAVAL A ， NAKHATE K T . Phloridzin attenuates lipopolysaccharide-induced cognitive impairment via antioxidant，anti-inflammatory and neuromodulatory activities [J ] . Cytokine ， 2021 ， 139 ： 155408 .

GAO J M ， CHEN N N ， LI N ， et al . Neuroprotective effects of trilobatin，a novel naturally occurring Sirt3 agonist from Lithocarpus polystachyus Rehd.，mitigate cerebral ischemia/reperfusion injury：involvement of TLR4/NF-κB and Nrf2/keap-1 signaling [J ] . Antioxid Redox Signal ， 2020 ， 33 （ 2 ）： 117 - 143 .

CHEN W J ， LIU M ， LI Z M ， et al . Phloretin alleviates sleep deprivation-induced cognitive impairment by reducing inflammation through PPARγ/NF-κB signaling pathway [J ] . Exp Neurol ， 2024 ， 382 ： 114949 .

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Analysis of components absorbed into blood and brain of Lithocarpus litseifolius leaves

DOI：10.6039/j.issn.1001-0408.2026.07.11

摘要

Abstract

关键词

Keywords

references