Meta-analysis of efficacy and safety of intranasal corticosteroids combined with oral H<sub>1</sub>-antihistamine in the treatment of allergic rhinitis

CHEN Huajiao; LUO Xiaohua; XIONG Qiong; YANG Liu

doi:10.6039/j.issn.1001-0408.2025.23.18

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Meta-analysis of efficacy and safety of intranasal corticosteroids combined with oral H₁-antihistamine in the treatment of allergic rhinitis

更新时间：2025-12-10

- Meta-analysis of efficacy and safety of intranasal corticosteroids combined with oral H₁-antihistamine in the treatment of allergic rhinitis
- ZHONGGUO YAOFANG Vol. 36, Issue 23, Pages: 2985-2989(2025)
- 作者机构：
  
  重庆大学附属涪陵医院耳鼻咽喉头颈外科，重庆　408000
- 作者简介：
- 基金信息：
- DOI：10.6039/j.issn.1001-0408.2025.23.18
  CLC： R976;R765.21
- Received：18 July 2025，
  
  Revised：2025-12-01，
  
  Accepted：01 December 2025，
  
  Published：15 December 2025
- 稿件说明：
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陈华娇,骆小华,熊琼,等.鼻用糖皮质激素联合口服H₁抗组胺药治疗过敏性鼻炎有效性与安全性的Meta分析 [J].中国药房,2025,36(23):2985-2989.

CHEN Huajiao,LUO Xiaohua,XIONG Qiong,et al.Meta-analysis of efficacy and safety of intranasal corticosteroids combined with oral H₁-antihistamine in the treatment of allergic rhinitis[J].ZHONGGUO YAOFANG,2025,36(23):2985-2989.
陈华娇,骆小华,熊琼,等.鼻用糖皮质激素联合口服H₁抗组胺药治疗过敏性鼻炎有效性与安全性的Meta分析 [J].中国药房,2025,36(23):2985-2989. DOI： 10.6039/j.issn.1001-0408.2025.23.18.

CHEN Huajiao,LUO Xiaohua,XIONG Qiong,et al.Meta-analysis of efficacy and safety of intranasal corticosteroids combined with oral H₁-antihistamine in the treatment of allergic rhinitis[J].ZHONGGUO YAOFANG,2025,36(23):2985-2989. DOI： 10.6039/j.issn.1001-0408.2025.23.18.

摘要

目的

评价鼻用糖皮质激素（INCS）联合口服H

抗组胺药（AH）治疗过敏性鼻炎的有效性和安全性。

方法

检索PubMed、Embase、中国期刊全文数据库、中文科技期刊数据库等，收集INCS联合口服AH（试验组）对比INCS（对照组）治疗过敏性鼻炎的随机对照试验（RCT），检索时限为建库起至2024年12月31日。筛选文献、提取资料、评价文献质量后，采用RevMan 5.3软件进行 Meta分析。

结果

共纳入12项RCT，共计1 842例患者。Meta分析结果显示，与对照组比较，试验组患者的喷嚏评分、流涕评分、鼻塞评分、鼻痒评分、鼻部症状总评分、眼部症状总评分、鼻结膜炎生活质量调查问卷评分的下降幅度更大（

＜0.05）；试验组患者的头痛发生率较对照组更低（

＜0.05），但两组患者的鼻出血、口鼻干燥、嗜睡、乏力的发生率及总不良事件发生率比较，差异均无统计学意义（

＞0.05）。

结论

与单用INCS比较，INCS联合口服AH治疗过敏性鼻炎的疗效和安全性均较好。

Abstract

OBJECTIVE

To evaluate the efficacy and safety of intranasal corticosteroids （INCS） combined with oral H

-antihistamine （AH） in the treatment of allergic rhinitis.

METHODS

A comprehensive literature search was conducted in PubMed， Embase， CNKI， and VIP database to collect randomized controlled trial （RCT） that INCS combined with AH （experimental group） versus INCS （control group） in the treatment of allergic rhinitis from the inception to December 31， 2024. After study selection， data extraction， and quality assessment， a meta-analysis was performed by using RevMan 5.3 software.

RESULTS

A total of 12 RCTs were included in the meta-analysis， with a total of 1 842 patients. Results of meta-a

nalysis showed that， compared with the control group， patients in the experimental group had a greater reduction in sneezing scores， rhinorrhea scores， nasal congestion scores， nasal itching scores， total nasal symptom scores， total ocular symptom scores， and rhinoconjunctivitis quality of life questionnaire scores （

＜0.05）. The incidence of headache was lower in the experimental group （

＜0.05）； whereas there were no significant differences between the two groups in the incidence of nosebleed， dryness of the mouth and nose， drowsiness， fatigue， and total adverse events （

＞0.05）.

CONCLUSIONS

Compared with INCS monotherapy， the combination of INCS and oral AH provides superior efficacy and safety in the treatment of allergic rhinitis.

关键词

Keywords

references

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Meta-analysis of efficacy and safety of intranasal corticosteroids combined with oral H1-antihistamine in the treatment of allergic rhinitis

DOI：10.6039/j.issn.1001-0408.2025.23.18

摘要

Abstract

关键词

Keywords

references

Meta-analysis of efficacy and safety of intranasal corticosteroids combined with oral H₁-antihistamine in the treatment of allergic rhinitis