Study on pharmacokinetic characteristics of ciprofol in pregnant and fetal rats

CHU Wenhao; QIN Yuanman; ZHANG Tiantian; XU Jiaqi; LI Ying; ZHANG Zhiqing

doi:10.6039/j.issn.1001-0408.2025.11.10

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Study on pharmacokinetic characteristics of ciprofol in pregnant and fetal rats

更新时间：2026-02-06

- Study on pharmacokinetic characteristics of ciprofol in pregnant and fetal rats
- ZHONGGUO YAOFANG Vol. 36, Issue 11, Pages: 1348-1351(2025)
- 作者机构：
  
  1.河北医科大学第二医院药学部，石家庄　050000
  2.河北医科大学药学院，石家庄　050011
- 作者简介：
- 基金信息：
- DOI：10.6039/j.issn.1001-0408.2025.11.10
  CLC： R971;R969.1
- Received：14 December 2024，
  
  Revised：2025-04-18，
  
  Accepted：21 April 2025，
  
  Published：15 June 2025
- 稿件说明：
移动端阅览
褚文昊,秦源蔓,张甜甜,等.环泊酚在孕鼠与胎鼠体内的药动学特征研究 [J].中国药房,2025,36(11):1348-1351.

CHU Wenhao,QIN Yuanman,ZHANG Tiantian,et al.Study on pharmacokinetic characteristics of ciprofol in pregnant and fetal rats[J].ZHONGGUO YAOFANG,2025,36(11):1348-1351.
褚文昊,秦源蔓,张甜甜,等.环泊酚在孕鼠与胎鼠体内的药动学特征研究 [J].中国药房,2025,36(11):1348-1351. DOI： 10.6039/j.issn.1001-0408.2025.11.10.

CHU Wenhao,QIN Yuanman,ZHANG Tiantian,et al.Study on pharmacokinetic characteristics of ciprofol in pregnant and fetal rats[J].ZHONGGUO YAOFANG,2025,36(11):1348-1351. DOI： 10.6039/j.issn.1001-0408.2025.11.10.

摘要

目的

研究环泊酚在孕鼠与胎鼠体内的药动学特征，为环泊酚在剖宫产中的应用提供参考。

方法

取孕鼠8只，尾静脉单次给予2.4 mg/kg环泊酚，分别于环泊酚给药后2、4、8、12、16、25、35、45、60、90 min取出1只胎鼠，然后同时采集孕鼠与胎鼠全血；采用高效液相色谱-串联质谱（HPLC-MS/MS）法测定孕鼠和胎鼠体内各时间点环泊酚血药浓度，计算各时间点胎鼠血药浓度与孕鼠血药浓度的比值（

值），并绘制

时间曲线，再采用DAS 2.0软件计算非房室模型药动学参数。

结果

与孕鼠相比，胎鼠体内环泊酚的

max

、AUC

0-90 min

、AUC

0-∞

均显著降低，平均滞留时间（MRT）显著升高（

＜0.05）。环泊酚的

时间曲线呈先上升后下降的趋势，

值在0.16～0.84之间，且在45 min时达到最大值（0.84）。

结论

环泊酚在孕鼠与胎鼠体内的药动学参数存在较大差异，其虽能透过胎盘屏障，但是在胎鼠体内的暴露量远低于孕鼠，有望成为剖宫产理想的麻醉用药。

Abstract

OBJECTIVE

To study the pharmacokinetic characteristics of ciprofol in pregnant and fetal rats， and provide reference for the application of ciprofol in cesarean section.

METHODS

Eight pregnant rats were selected. A single dose of 2.4 mg/kg of ciprofol was administered via the tail vein. One fetal rat was selected at 2， 4， 8， 12， 16， 25， 35， 45， 60， and 90 minutes respectively after ciprofol administration. Subsequently， whole blood samples were collected simultaneously from both the pregnant rats and fetal rats. HPLC-MS/MS method was used to determine the concentration of ciprofol in the bodies of pregnant and fetal rats. The ratios of fetal-to-maternal blood concentrations （

ratios） at each time point were calculated， and the

-time curves were plotted. Subsequently， non-compartmental pharmacokinetic parameters were computed using DAS 2.0 software.

RESULTS

Compared with pregnant rats，

max

， AUC

0-90 min

and AUC

0-∞

of ciprofol in fetal rats were decreased significantly， while MRT was increased significantly （

＜0.05）. The

curve of ciprofol initially increased and then decreased， and between 0.16-0.84， reaching a maximum value of 0.84 at 45 minutes.

CONCLUSIONS

Ciprofol can penetrate the placental barrier， and there are significant differences in pharmacokinetic parameters between pregnant and fetal rats. Moreover， the exposure level of ciprofol in fetal rats is much lower than that in pregnant rats. Therefore， ciprofol shows promise as an ideal anesthetic agent for cesarean section delivery.

关键词

Keywords

references

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