OBJECTIVE

2

To investigate the effects of Estradiol tablet/Estradiol and dydrogesterone tablet combined with Dan’e fukang decoction on postoperative recovery， sex hormone levels， uterine artery blood flow， and endometrium in patients with high risk of endometrial basal layer injury after induced abortion， and evaluate the safety of drug use.

METHODS

2

A retrospective analysis was conducted on the clinical data of 244 patients with high risk of endometrial basal layer injury who underwent artificial abortions in our hospital between January 2022 and December 2023. They were divided into control group （120 cases） and observation group （124 cases） according to postoperative medication plan. All patients received anti-infective treatment after induced abortion. Based on it， control group was given Estradiol tablet/Estradiol and dydrogesterone tablet， and observation group was given Estradiol tablet/Estradiol and dydrogesterone tablet+Dan’e fukang decoction， for consecutive 28 d. The time of vaginal bleeding， abdominal pain， return of menstruation， and vaginal bleeding volume were observed in 2 groups； serum sex hormone levels [serum follicle stimulating hormone （FSH）， luteinizing hormone （LH）， estradiol， and progesterone]， uterine artery blood flow parameters [peak systolic blood flow velocity （PSV）， pulsatility index （PI）， and resistance index （RI）] and endometrial thickness were compared between the two groups before and after treatment. The occurrence of complications and adverse reactions in patients were recorded.

RESULTS

2

After treatment， the duration of vaginal bleeding， vaginal bleeding volume， duration of abdominal pain， and menstrual cycle recovery time in observation group were significantly shorter or less than the control group （

P

＜0.05）. After treatment， both groups exhibited a significant increase in endometrial thickness， serum FSH and LH levels， and PSV， compared to before treatment， and the observation group was significantly thicker/higher than the control group （

P

＜0.05）； the levels of estradiol and progesterone， as well as the values of PI and RI， were significantly lower than those before treatment， and the observation group was significantly lower than the control group （

P

＜0.05）. The total incidence of postoperative complications in observation group was significantly lower than control group （

P

＜0.05）， but there was no significant difference in the total incidence of adverse reactions between the 2 groups （

P

＞0.05）.

CONCLUSIONS

2

Estradiol tablet/Estradiol and dydrogesterone tablet combined with Dan’e fukang decoction can accelerate the postoperative recovery of patients with high risk of endometrial basal layer injury after induced abortion， promote endometrial growth， regulate serum sex hormone levels， improve uterine artery blood flow， reduce postoperative complications， and have good safety.