Glofitamab for diffuse large B cell lymphoma

ZHENG Li; ZHANG Kaihua; SUN Xuelin

doi:10.6039/j.issn.1001-0408.2023.24.20

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Glofitamab for diffuse large B cell lymphoma

更新时间：2025-09-23

- Glofitamab for diffuse large B cell lymphoma
- ZHONGGUO YAOFANG Vol. 34, Issue 24, Pages: 3064-3067(2023)
- 作者机构：
  
  1.中国航天科工集团七三一医院药学部，北京　100074
  2.中国航天科工集团七三一医院胸外科，北京　100074
  3.北京医院药学部，北京　100730
- 作者简介：
- 基金信息：
- DOI：10.6039/j.issn.1001-0408.2023.24.20
  CLC： R979.1
- Received：21 July 2023，
  
  Revised：2023-11-01，
  
  Accepted：07 November 2023，
  
  Published：30 December 2023
- 稿件说明：
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郑丽,张凯华,孙雪林.弥漫大B细胞淋巴瘤治疗新药格菲妥单抗 [J].中国药房,2023,34(24):3064-3067.

ZHENG Li,ZHANG Kaihua,SUN Xuelin.Glofitamab for diffuse large B cell lymphoma[J].ZHONGGUO YAOFANG,2023,34(24):3064-3067.
郑丽,张凯华,孙雪林.弥漫大B细胞淋巴瘤治疗新药格菲妥单抗 [J].中国药房,2023,34(24):3064-3067. DOI： 10.6039/j.issn.1001-0408.2023.24.20.

ZHENG Li,ZHANG Kaihua,SUN Xuelin.Glofitamab for diffuse large B cell lymphoma[J].ZHONGGUO YAOFANG,2023,34(24):3064-3067. DOI： 10.6039/j.issn.1001-0408.2023.24.20.

摘要

弥漫大B细胞淋巴瘤（DLBCL）是一种来源于成熟B细胞的恶性肿瘤，目前其临床治疗以化学治疗为主，但仍有部分患者会在治疗后复发或进展为难治性DLBCL。2023年6月15日，美国FDA批准抗CD3/CD20双特异性单克隆抗体格菲妥单抗上市，为既往接受过二线或二线以上系统治疗后复发或进展为难治性DLBCL的患者提供了新的治疗方案。本文对格菲妥单抗的药理作用、临床研究、安全性及用法用量等进行了简要概述。格菲妥单抗主要通过促进T细胞的活化和增殖，激活T细胞释放肿瘤细胞杀伤蛋白，进而介导B细胞的裂解而发挥治疗DLBCL的作用。临床研究显示，格菲妥单抗对复发或难治性DLBCL具有较好的完全缓解率和客观缓解率，其常见不良反应包括轻/中度细胞因子释放综合征、肌肉骨骼疼痛、皮疹和疲劳，未见明显的药物相互作用。

Abstract

Diffuse large B cell lymphoma （DLBCL） is a malignant tumor derived from mature B cells. Currently， chemotherapy is still the main clinical treatment. However， some patients experience recurrence or refractory conditions after treatment. On June 15， 2023， the FDA approved the marketing of glofitamab， a CD3/CD20 bispecific monoclonal antibody， to provide the new treatment plan for patients with recurrent or refractory DLBCL after receiving 2-line or above systemic treatment. This article reviews pharmacological effects， clinical studies， safety， usage and dosage of glofitamab. Glofitamab mainly plays a therapeutic role in DLBCL by promoting the activation and proliferation of T cells，activating T cells to release tumor cell-killing proteins， and mediating the lysis of B cells. Clinical studies have shown that glofitamab has a better complete and objective response rate for recurrent or refractory DLBCL. Common adverse reactions caused by glofitamab include mild/moderate cytokine release syndrome， musculoskeletal pain， rash， fatigue， and so on，without significant drug interactions.

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references

DUNLEAVY K ， ERDMANN T ， LENZ G . Targeting the B-cell receptor pathway in diffuse large B-cell lymphoma [J ] . Cancer Treat Rev ， 2018 ， 65 ： 41 - 46 .

佟丹江 . 弥漫大B细胞淋巴瘤的流行病学分析 [J ] . 中国现代药物应用， 2016 ， 10 （ 8 ）： 46 - 47 .

TONG D J . Epidemiological analysis of diffuse large B-cell lymphoma [J ] . Chin J Mod Drug Appl ， 2016 ， 10 （ 8 ）： 46 - 47 .

SEHN L H ， GASCOYNE R D . Diffuse large B-cell lymphoma：optimizing outcome in the context of clinical and biologic heterogeneity [J ] . Blood ， 2015 ， 125 （ 1 ）： 22 - 32 .

GOLDFINGER M ， COOPER D L . lenalidomide in DLBCL：are we past the cell of origin? [J ] . Clin Adv Hematol Oncol ， 2021 ， 19 （ 5 ）： 320 - 325 .

MINSON A ， DICKINSON M . Glofitamab CD20-TCB bispecific antibody [J ] . Leuk Lymphoma ， 2021 ， 62 （ 13 ）： 3098 - 3108 .

SUROWKA M ， SCHAEFER W ， KLEIN C . Ten years in the making：application of CrossMab technology for the development of therapeutic bispecific antibodies and antibody fusion proteins [J ] . mAbs ， 2021 ， 13 （ 1 ）： 1967714 .

CREMASCO F ， MENIETTI E ， SPEZIALE D ， et al . Cross-linking of T cell to B cell lymphoma by the T cell bispecific antibody CD20-TCB induces IFNγ/CXCL10-dependent peripheral T cell recruitment in humanized murine model [J ] . PLoS One ， 2021 ， 16 （ 1 ）： e0241091 .

FDA . Glofitamab-gxbm（Columvi） prescribing information [EB/OL ] .（ 2023-06-15 ）[ 2023-07-21 ] . https：//www.accessdata.fda.gov/drugsatfda_docs/label/2023/761309s000lbl.pdf https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/761309s000lbl.pdf .

DICKINSON M J ， CARLO-STELLA C ， MORSCHHAUSER F ， et al . Glofitamab for relapsed or refractory diffuse large B-cell lymphoma [J ] . N Engl J Med ， 2022 ， 387 （ 24 ）： 2220 - 2231 .

SONG Y Q ， ZHANG H L ， HUANG H Q ， et al . Glo-fitamab monotherapy demonstrates high complete response rates and manageable safety in Chinese patients with relapsed or refractory diffuse large B-cell lymphoma and ≥2 prior therapies [J ] . Blood ， 2022 ， 140 （supplement 1 ）： 12050 - 12051 .

HUTCHINGS M ， SUREDA A ， TEROL M J ， et al . Glofi-tamab（glofit）in combination with polatuzumab vedotin（pola）：phase Ⅰb/Ⅱ preliminary data support manageable safety and encouraging efficacy in relapsed/refractory（R/R）diffuse large B-cell lymphoma（DLBCL） [J ] . Blood ， 2021 ， 138 （ Supplement 1 ）： 525 .

TOPP M S ， TANI M ， DICKINSON M ， et al . Glofitamab plus R-CHOP induces high response rates and a favorable safety profile in patients with previously untreated diffuse large B-cell lymphoma（DLBCL）：results from a phase Ⅰb study [J ] . Blood ， 2022 ， 140 （ Supplement 1 ）： 1775 - 1777 .

GUST J ， HAY K A ， HANAFI L A ， et al . Endothelial activation and blood-brain barrier disruption in neurotoxicity after adoptive immunotherapy with CD19 CAR-T cells [J ] . Cancer Discov ， 2017 ， 7 （ 12 ）： 1404 - 1419 .

MAUDE S L ， FREY N ， SHAW P A ， et al . Chimeric antigen receptor T cells for sustained remissions in leukemia [J ] . N Engl J Med ， 2014 ， 371 （ 16 ）： 1507 - 1517 .

BACAC M ， COLOMBETTI S ， HERTER S ， et al . CD20-TCB with obinutuzumab pretreatment as next-generation treatment of hematologic malignancies [J ] . Clin Cancer Res ， 2018 ， 24 （ 19 ）： 4785 - 4797 .

SANCHEZ-PAULETE A R ， LABIANO S ， RODRIGUEZ-RUIZ M E ， et al . Deciphering CD137（4-1BB）signaling in T-cell costimulation for translation into successful cancer immunotherapy [J ] . Eur J Immunol ， 2016 ， 46 （ 3 ）： 513 - 522 .

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