Optimization of water extraction process of Maxing kechuan granules

LIANG Dongqian; WANG Jingjing; WANG Xin; CHAI Tianchuan; LI Chunhua

doi:10.6039/j.issn.1001-0408.2023.17.09

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Optimization of water extraction process of Maxing kechuan granules

更新时间：2025-09-25

- Optimization of water extraction process of Maxing kechuan granules
- ZHONGGUO YAOFANG Vol. 34, Issue 17, Pages: 2095-2100(2023)
- 作者机构：
  
  1.河北中医药大学药学院，石家庄　050200
  2.保定市第一中医院脑病科，河北保定　071000
  3.河北省中医院制剂室，石家庄　050011
  4.河北省中药组方制剂技术创新中心，石家庄　050091
  5.河北省高校中药开发与产业化应用技术研发中心，石家庄　050091
- 作者简介：
- 基金信息：
- DOI：10.6039/j.issn.1001-0408.2023.17.09
  CLC： R917;R943
- Received：16 March 2023，
  
  Revised：2023-07-28，
  
  Accepted：28 July 2023，
  
  Published：15 September 2023
- 稿件说明：
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梁董茜,王晶晶,王欣,等.麻杏咳喘颗粒的水提工艺优化[J].中国药房,2023,34(17):2095-2100.

LIANG Dongqian,WANG Jingjing,WANG Xin,et al.Optimization of water extraction process of Maxing kechuan granules[J].ZHONGGUO YAOFANG,2023,34(17):2095-2100.
梁董茜,王晶晶,王欣,等.麻杏咳喘颗粒的水提工艺优化[J].中国药房,2023,34(17):2095-2100. DOI： 10.6039/j.issn.1001-0408.2023.17.09.

LIANG Dongqian,WANG Jingjing,WANG Xin,et al.Optimization of water extraction process of Maxing kechuan granules[J].ZHONGGUO YAOFANG,2023,34(17):2095-2100. DOI： 10.6039/j.issn.1001-0408.2023.17.09.

摘要

目的

优选麻杏咳喘颗粒的水提工艺。

方法

以药效成分盐酸麻黄碱、岩白菜素、升麻素苷、5-

-甲基维斯阿米醇苷、柚皮苷、橙皮苷含量及出膏率为考察指标，采用层次分析（AHP）-熵权法确定各指标权重，并计算综合评分作为响应值，在单因素实验的基础上采用Box-Behnken响应面法对各指标进行考察，优选麻杏咳喘颗粒的最佳水提工艺，并进行工艺验证。

结果

优选出麻杏咳喘颗粒的最佳水提工艺为浸泡时间40 min，加水量8倍，总提取时间180 min。经3次验证实验结果显示，综合评分为94.82分（RSD＝0.96%，

＝3），与预测值94.64分差异较小。

结论

优化后的麻杏咳喘颗粒水提工艺稳定可靠，可为该制剂的进一步开发提供参考。

Abstract

OBJECTIVE

To optimize the water extraction process of Maxing kechuan granules.

METHODS

With the contents of ephedrine hydrochloride， bergenin， prim-

-glucosylcimifugin， 5-

-methylvisamin， naringin and hesperidin and the rate of extraction as the evaluation indexes， the weight was determined by the analytic hierarchy process（APH）-entropy weight method， and the comprehensive score was calculated as the response value. Based on the single-factor test， the Box-Behnken response surface method was used to investigate the factors， and the best water extraction process of Maxing kechuan granules was optimized； process validation was also carried out.

RESULTS

The best water extraction process of Maxing kechuan granules optimized was as follows： soaking for 40 minutes， adding 8 times

water， and extracting for 180 minutes. After three validation tests， the comprehensive score was 94.82 （RSD＝0.96%，

＝3）， which had a small difference from the predicted value of 94.64.

CONCLUSIONS

The water extraction process of Maxing kechuan granules is stable and reliable， which can provide a reference for the development of the preparation.

关键词

Keywords

references

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