ZHAO Chuncao,ZENG Jia.Recent advances on pharmacological effect and safety of Ampelopsis grossedentata[J].ZHONGGUO YAOFANG,2023,34(03):380-384. DOI: 10.6039/j.issn.1001-0408.2023.03.24.
Recent advances on pharmacological effect and safety of Ampelopsis grossedentata
as a traditional medicinal plant, has many pharmacological effects. Pharmacological effects and possible mechanisms are summarized in this paper based on the research progress of
A. grossedentata
at home and abroad in recent years, involving digestive system (treating liver injury and improving intestinal flora imbalance), endocrine system (treating hyperglycemia, hyperlipidemia and hyperuricemia), cardiovascular system (treating hypertension, vascular injury, myocardial ischemia-reperfusion injury and myocardial hypertrophy), immune system (anti-inflammatory and anti-tumor) and nervous system (adjuvant treatment for chronic degenerative diseases). By summarizing the animal acute toxicity test, long-term toxicity test and cell test results of
A. grossedentata
in the literature, it is confirmed that its safety is good.
关键词
Keywords
references
XIE K , HE X , CHEN K Y , et al . Antioxidant properties of a traditional vine tea, Ampelopsis grossedentata [J ] . Antioxidants (Basel) , 2019 , 8 ( 8 ): 295 .
XIE K , HE X , CHEN K Y , et al . Ameliorative effects and molecular mechanisms of vine tea on western diet-induced NAFLD [J ] . Food Funct , 2020 , 11 ( 7 ): 5976 - 5991 .
CHEN Y J , SONG H Y , ZHANG Z W , et al . Extracts of vine tea improve diet-induced non-alcoholic steatohepatitis through AMPK-LXRα signaling [J ] . Front Pharmacol , 2021 , 12 : 711763 .
ZENG X L , YANG J N , HU O , et al . Dihydromyricetin ameliorates nonalcoholic fatty liver disease by improving mitochondrial respiratory capacity and redox homeostasis through modulation of SIRT3 signaling [J ] . Antioxid Redox Signal , 2019 , 30 ( 2 ): 163 - 183 .
FAN L , ZHAO X Y , TONG Q , et al . Interactions of dihydromyricetin,a flavonoid from vine tea ( Ampelopsis grossedentata ) with gut microbiota [J ] . J Food Sci , 2018 , 83 ( 5 ): 1444 - 1453 .
XIANG J M , LV Q Y , YI F , et al . Dietary supplementation of vine tea ameliorates glucose and lipid metabolic disorder via Akt signaling pathway in diabetic rats [J ] . Molecules , 2019 , 24 ( 10 ): 1866 .
WAN W T , JIANG B P , SUN L , et al . Metabolomics reveals that vine tea ( Ampelopsis grossedentata ) prevents high-fat-diet-induced metabolism disorder by improving glucose homeostasis in rats [J ] . PLoS One , 2017 , 12 ( 8 ): e0182830 .
TONG Q , FAN L , ZHOU H , et al . Dihydromyricetin from vine tea ( Ampelopsis grossedentata ) prevents diet-induced obesity by modulating the gut microbiota composition [J/OL ] . Soc Sci Electron Publ , 2018 [ 2022-05-02 ] . http://dx.doi.org/10.2139/ssrn.3263647 http://dx.doi.org/10.2139/ssrn.3263647 .
SHIMIZU Y , SAKURADA T , MATSUOKA S , et al . Vine tea ( Ampelopsis grossedentata ) extract suppresses postprandial uric acid levels via both inhibition of xanthine oxidase and facilitation of uric acid excretion [J ] . Curr Dev Nutr , 2020 , 4 ( Supplement_2 ): 474 .
YE T Y , PENG J , LIU X , et al . Orphan nuclear receptor TR3/Nur77 differentially regulates the expression of integrins in angiogenesis [J ] . Microvasc Res , 2019 , 122 : 22 - 33 .
HUANG B H , LI Y P , YAO Y L , et al . Dihydromyricetin from Ampelopsis grossedentata protects against vascular neointimal formation via induction of TR3 [J ] . Eur J Pharmacol , 2018 , 838 : 23 - 31 .
SONG Q Y , LIU L L , YU J , et al . Dihydromyricetin attenuated Ang Ⅱ induced cardiac fibroblasts proliferation related to inhibitory of oxidative stress [J ] . Eur J Pharmacol , 2017 , 807 : 159 - 167 .
LUO Y , LU S , DONG X , et al . Dihydromyricetin protects human umbilical vein endothelial cells from injury through ERK and Akt mediated Nrf2/HO-1 signaling pathway [J ] . Apoptosis , 2017 , 22 ( 8 ): 1013 - 1024 .
LIU S S , AI Q D , FENG K , et al . The cardioprotective effect of dihydromyricetin prevents ischemia-reperfusion-induced apoptosis in vivo and in vitro via the PI3K/Akt and HIF-1α signaling pathways [J ] . Apoptosis , 2016 , 21 ( 12 ): 1366 - 1385 .
CHEN Y , LUO H Q , SUN L L , et al . Dihydromyricetin attenuates myocardial hypertrophy induced by transverse aortic constriction via oxidative stress inhibition and SIRT3 pathway enhancement [J ] . Int J Mol Sci , 2018 , 19 ( 9 ): 2592 .
ZUO Y Z , XU Q , LU Y J , et al . Dihydromyricetin induces apoptosis in a human choriocarcinoma cell line [J ] . Oncol Lett , 2018 , 16 ( 4 ): 4229 - 4234 .
WANG Z Y , SUN X T , FENG Y Y , et al . Dihydromyri- cetin reverses MRP2-mediated MDR and enhances anticancer activity induced by oxaliplatin in colorectal cancer cells [J ] . Anticancer Drugs , 2017 , 28 ( 3 ): 281 - 288 .
KAO S J , LEE W J , CHANG J H , et al . Suppression of reactive oxygen species-mediated ERK and JNK activation sensitizes dihydromyricetin-induced mitochondrial apoptosis in human non-small cell lung cancer [J ] . Environ Toxicol , 2017 , 32 ( 4 ): 1426 - 1438 .
MARINO B L B , DE SOUZA L R , SOUSA K P A , et al . Parkinson’s disease:a review from pathophysiology to treatment [J ] . Mini Rev Med Chem , 2020 , 20 ( 9 ): 754 - 767 .
ZHAO D F , FAN Y F , YU H N , et al . Discovery and cha- racterization of flavonoids in vine tea as catechol-O-methyltransferase inhibitors [J ] . Fitoterapia , 2021 , 152 : 104913 .
CACABELOS R . Parkinson’s disease:from pathogenesis to pharmacogenomics [J ] . Int J Mol Sci , 2017 , 18 ( 3 ): 551 .
MUSTAPHA M , MAT TAIB C N . MPTP-induced mouse model of Parkinson’s disease:a promising direction of therapeutic strategies [J ] . Bosn J Basic Med Sci , 2021 , 21 ( 4 ): 422 - 433 .
REN Z X , ZHAO Y F , CAO T , et al . Dihydromyricetin protects neurons in an MPTP-induced model of Parkinson’s disease by suppressing glycogen synthase kinase-3 beta activity [J ] . Acta Pharmacol Sin , 2016 , 37 ( 10 ): 1315 - 1324 .
TSUCHIDA A , NAKAGAWA T , ITAKURA Y , et al . The effects of brain-derived neurotrophic factor on insulin signal transduction in the liver of diabetic mice [J ] . Diabetologia , 2001 , 44 ( 5 ): 555 - 566 .