Advances of the mechanism study on Chinese herb monomers in improving premature ovarian failure

YAN Rugen; WANG Yuqi; HE Jing; CHEN Yin; CAI Pingping; LI Changzhong

doi:10.6039/j.issn.1001-0408.2022.21.23

您当前的位置：

首页 >

文章列表页 >

Advances of the mechanism study on Chinese herb monomers in improving premature ovarian failure

更新时间：2025-09-28

- Advances of the mechanism study on Chinese herb monomers in improving premature ovarian failure
- ZHONGGUO YAOFANG Vol. 33, Issue 21, Pages: 2685-2688(2022)
- 作者机构：
  
  1.南京中医药大学中医学院·中西医结合学院，南京　210023
  2.山东中医药大学第一临床医学院，济南　250355
  3.盱眙县中医院妇产科，江苏盱眙　211700
  4.山东第一医科大学附属省立医院中医科，济南　250012
- 作者简介：
- 基金信息：
- DOI：10.6039/j.issn.1001-0408.2022.21.23
  CLC： R965
- Received：24 March 2022，
  
  Revised：2022-08-26，
  
  Published：15 November 2022
- 稿件说明：
移动端阅览
严如根,王雨琦,何静,等.中药单体改善卵巢早衰的作用机制研究进展[J].中国药房,2022,33(21):2685-2688.

YAN Rugen,WANG Yuqi,HE Jing,et al.Advances of the mechanism study on Chinese herb monomers in improving premature ovarian failure[J].ZHONGGUO YAOFANG,2022,33(21):2685-2688.
严如根,王雨琦,何静,等.中药单体改善卵巢早衰的作用机制研究进展[J].中国药房,2022,33(21):2685-2688. DOI： 10.6039/j.issn.1001-0408.2022.21.23.

YAN Rugen,WANG Yuqi,HE Jing,et al.Advances of the mechanism study on Chinese herb monomers in improving premature ovarian failure[J].ZHONGGUO YAOFANG,2022,33(21):2685-2688. DOI： 10.6039/j.issn.1001-0408.2022.21.23.

摘要

卵巢早衰是妇科内分泌常见病，可引发卵巢内卵泡发育停滞或提前衰竭，从而导致卵巢功能丧失，严重影响女性的身心健康。我国传统中药治疗卵巢早衰的毒副作用较少、效果显著。中药单体是中药发挥药效的活性成分，且化学结构确定。笔者从中药单体角度出发，综述其改善卵巢早衰的作用机制，结果发现，淫羊藿苷、槲皮素、白藜芦醇、人参皂苷Rg

可通过激活卵巢组织磷脂酰肌醇3-激酶/蛋白激酶B信号通路、抑制氧化应激和颗粒细胞凋亡、促进卵巢细胞自噬、调节性激素水平来改善卵巢早衰模型动物的卵巢功能；葛根素、白藜芦醇可通过干预卵巢组织Wnt/

-连环蛋白信号通路、减轻氧化应激反应、抑制卵泡闭锁来改善卵巢早衰模型动物的卵巢功能等。虽然目前中药单体在改善卵巢早衰方面具有一定效果，但大多数停留在实验阶段，尚不能客观评价其改善卵巢早衰的临床疗效。后续应加强中药单体新剂型的开发，以期为治疗卵巢早衰的新药开发奠定基础。

Abstract

Premature ovarian failure （POF） is a common gynecological endocrine disease， which can cause follicular development stagnation or premature failure in the ovary， leading to ovarian function loss， and seriously affecting women’s physical and mental health. Traditional Chinese medicine shows less toxicity and side effects but significant effect in the treatment of POF. Chinese herb monomers are the active ingredients of traditional Chinese medicine that exert their effects， and their chemical structure are determined. From the perspective of Chinese herb monomers， the author reviewed the mechanism of their effect on improving POF. The results showed that icariin， quercetin， resveratrol and ginsenoside Rg

could improve the ovarian function of POF model animals by activating the phosphatidylinositol 3-kinase/protein kinase B signaling pathway， inhibiting oxidative stress and apoptosis of granulosa cells， promoting ovarian autophagy， and regulating the level of sex hormones； puerarin and resveratrol can improve the ovarian function of POF model by interfering with Wnt/

-catenin signaling pathway， reducing oxidative stress response， and inhibiting follicular atresia. Although the Chinese herb monomers have certain effect in improving POF， most of them remain in the experimental stage， and the clinical efficacy in improving POF cannot be objectively evaluated. In the future， the development of new dosage forms of Chinese herb monomers should be strengthened to lay a foundation for the development of new drugs for treating POF.

关键词

Keywords

references

SÜKÜR Y E ， KIVANÇLI I B ， OZMEN B . Ovarian aging and premature ovarian failure [J ] . J Turk Ger Gynecol Assoc ， 2014 ， 15 （ 3 ）： 190 - 196 .

LIM Y M ， JEONG K ， LEE S R ， et al . Association between premature ovarian insufficiency，early menopause，socioeconomic status in a nationally representative sample from Korea [J ] . Maturitas ， 2019 ， 121 ： 22 - 27 .

李锦英，张兆萍，叶金飞，等 . 基于网络药理学的菟丝子-枸杞子药对治疗卵巢早衰的作用机制研究 [J ] . 中国药房， 2020 ， 31 （ 18 ）： 2202 - 2209 .

孙晓峰，阳松威，贺又舜，等 . 左归丸对化疗性卵巢早衰小鼠卵巢组织中缝隙连接蛋白43表达的影响 [J ] . 中国药房， 2017 ， 28 （ 22 ）： 3044 - 3047 .

ZHANG C ， XU X . Advancement in the treatment of diminished ovarian reserve by traditional Chinese and Wes- tern medicine [J ] . Exp Ther Med ， 2016 ， 11 （ 4 ）： 1173 - 1176 .

胡金芳，刘慧萍，张楚洁，等 . 尤昭玲运用助卵方治疗卵巢早衰经验 [J ] . 中华中医药杂志， 2021 ， 36 （ 6 ）： 3369 - 3372 .

张兵，刘金星 . 卵巢早衰的中西医临床研究及治疗进展 [J ] . 现代中西医结合杂志， 2020 ， 29 （ 32 ）： 3643 - 3648 .

董若曦 . 淫羊藿苷抑制氧化应激改善大鼠化疗损伤性卵巢早衰的机制研究 [D ] . 上海：上海中医药大学， 2019 .

董若曦，朱小丹，樊伯珍，等 . 淫羊藿苷对顺铂致卵巢早衰大鼠卵巢储备功能的作用研究 [J ] . 浙江医学， 2019 ， 41 （ 3 ）： 230 - 233 .

WANG J L ， LIU B ， ZHANG C ， et al . Effects of icariin on ovarian function in d-galactose-induced aging mice [J ] . Theriogenology ， 2019 ， 125 ： 157 - 167 .

LI N ， WANG J ， WANG X ， et al . Icariin exerts a protective effect against d-galactose induced premature ovarian fai- lure via promoting DNA damage repair [J ] . Biomedecine Pharmacother ， 2019 ， 118 ： 109218 .

CHEN C ， LI S ， HU C ， et al . Protective effects of puerarin on premature ovarian failure via regulation of Wnt/ β-catenin signaling pathway and oxidative stress [J ] . Reprod Sci ， 2021 ， 28 （ 4 ）： 982 - 990 .

张洪英，梁瑞，曹长顺，等 . 葛根素对顺铂诱导小鼠卵巢早衰的作用研究 [J ] . 中国现代医学杂志， 2021 ， 31 （ 15 ）： 67 - 73 .

黄长盛，贺守第，管雁丞，等 . 菟丝子黄酮和槲皮素对雷公藤多苷致卵巢早衰大鼠卵巢功能的影响 [J ] . 中国临床药理学杂志， 2020 ， 36 （ 6 ）： 667 - 670 .

ELKADY M A ， SHALABY S ， FATHI F ， et al . Effects of quercetin and rosuvastatin each alone or in combination on cyclophosphamide-induced premature ovarian failure in female albino mice [J ] . Hum Exp Toxicol ， 2019 ， 38 （ 11 ）： 1283 - 1295 .

ZHENG S Y ， MA M Y ， CHEN Y X ， et al . Effects of quercetin on ovarian function and regulation of the ovarian PI3K/Akt/FoxO3a signalling pathway and oxidative stress in a rat model of cyclophosphamide-induced premature ovarian failure [J ] . Basic Clin Pharmacol Toxicol ， 2022 ， 130 （ 2 ）： 240 - 253 .

HUANG C S ， NING Y ， GUAN Y C ， et al . Quercetin and flavonoids from Cuscuta chinensis lam. inhibit Triptery- gium glycoside-induced premature ovarian failure progression via PI3K-AKT signaling pathway [J ] . Pharmacogn Mag ， 2021 ， 17 ： 475 - 481 .

LIN J J ， NIE X L ， XIONG Y ， et al . Fisetin regulates gut microbiota to decrease CCR9 + /CXCR3 + /CD4 + T-lymphocyte count and IL-12 secretion to alleviate premature ovarian failure in mice [J ] . Am J Transl Res ， 2020 ， 12 （ 1 ）： 203 - 247 .

MANTAWY E M ， SAID R S ， ABDEL-AZIZ A K . Mechanistic approach of the inhibitory effect of chrysin on inflammatory and apoptotic events implicated in radiation-induced premature ovarian failure：emphasis on TGF-β/MAPKs signaling pathway [J ] . Biomedecine Pharmacother ， 2019 ， 109 ： 293 - 303 .

JIANG Y ， ZHANG Z Y ， CHA L J ， et al . Resveratrol plays a protective role against premature ovarian failure and prompts female germline stem cell survival [J ] . Int J Mol Sci ， 2019 ， 20 （ 14 ）： E3605 .

修银玲，孙凯旋，于月新 . 白藜芦醇对小鼠卵巢早衰的干预作用及可能机制 [J ] . 中国比较医学杂志， 2022 ， 32 （ 7 ）： 81 - 86，93 .

LI N ， LIU L L . Mechanism of resveratrol in improving ovarian function in a rat model of premature ovarian insufficiency [J ] . J Obstet Gynaecol Res ， 2018 ， 44 （ 8 ）： 1431 - 1438 .

ALHARBI H ， ALSHEHRI A S ， AHMAD M ， et al . Pro- mising anti-cervical carcinoma and inflammatory agent，resveratrol targets poly （ADP-ribose） polymerase 1 （PARP-1） induced premature ovarian failure with a potent enzymatic modulatory activity [J ] . J Reprod Immunol ， 2021 ， 144 ： 103272 .

FURAT RENCBER S ， KURNAZ OZBEK S ， ERALDEMIR C ， et al . Effect of resveratrol and metformin on ovarian reserve and ultrastructure in PCOS：an experimental study [J ] . J Ovarian Res ， 2018 ， 11 （ 1 ）： 55 .

YAN Z J ， DAI Y J ， FU H L ， et al . Curcumin exerts a protective effect against premature ovarian failure in mice [J ] . J Mol Endocrinol ， 2018 ， 60 （ 3 ）： 261 - 271 .

MELEKOGLU R ， CIFTCI O ， ERASLAN S ， et al . Beneficial effects of curcumin and capsaicin on cyclophospha- mide-induced premature ovarian failure in a rat model [J ] . J Ovarian Res ， 2018 ， 11 （ 1 ）： 33 .

HUANG J Z ， ZENG F ， XU Q G ， et al . Cryptotanshinone decreases granulosa cell apoptosis and restores ovarian function in mice with premature ovarian failure [J ] . Gen Physiol Biophys ， 2020 ， 39 （ 3 ）： 277 - 283 .

HE L L ， LING L ， WEI T Q ， et al . Ginsenoside Rg 1 improves fertility and reduces ovarian pathological damages in premature ovarian failure model of mice [J ] . Exp Biol Med （Maywood）， 2017 ， 242 （ 7 ）： 683 - 691 .

刘小虎 . 基于PI3K/Akt/mTOR自噬通路探讨人参皂苷Rg 1 延缓D-gal诱导的卵巢早衰小鼠模型卵巢早衰的机制 [D ] . 大理：大理大学， 2021 .

颜倩，石丹宁，杨佳迪，等 . 人参皂苷Rg 1 对顺铂损伤大鼠卵巢颗粒细胞的保护作用及其分子机制 [J ] . 中南药学， 2022 ， 20 （ 5 ）： 1028 - 1033 .

LIU Z T ， LI F H ， XUE J W ， et al . Esculentoside A rescues granulosa cell apoptosis and folliculogenesis in mice with premature ovarian failure [J ] . Aging （Albany NY）， 2020 ， 12 （ 17 ）： 16951 - 16962 .

Views

748

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Research progress on the mechanism of traditional Chinese medicine monomers acting on myelosuppression after chemotherapy based on the four properties theory

Research progress on active components of traditional Chinese medicine inhibiting esophageal carcinoma by targeting mitochondrial apoptosis pathway

Research progress on the action mechanism of monomer components and compound formulations of traditional Chinese medicine in the treatment of vitiligo

Research progress on mechanism of antidepressant action of curcumin

Research progress on the improvement of myocardial fibrosis by traditional Chinese medicine through regulation of NLRP3 inflammasome

Related Author

ZHANG Sihan

WANG Tingting

ZHAO Zhifen

KANG Hanyu

JI Jiaqi

GUO Ziqiang

LIU Tong

JIANG Shiqing

Related Institution

Pediatric Hospital， the First Affiliated Hospital of Henan University of Chinese Medicine

Dept. of Emergency， the First Affiliated Hospital of Henan University of Chinese Medicine

First Clinical Medical College， Henan University of Chinese Medicine

Dept. of Hematology and Oncology， the First Affiliated Hospital of Henan University of Chinese Medicine

Dept. of Oncology， Henan Provincial Hospital of Traditional Chinese Medicine/the Second Affiliated Hospital of Henan University of Chinese Medicine

⁰