Impact of compound nutritional preparations on clinical prognosis of patients undergoing cardiovascular surgery: A randomized controlled study

XIN Wenbin; BAI Qian; NI Xiangmin; WANG Yong; LIANG Xinyu; MI Mantian; WANG Jian

doi:10.16016/j.2097-0927.202510016

您当前的位置：

首页 >

文章列表页 >

Impact of compound nutritional preparations on clinical prognosis of patients undergoing cardiovascular surgery: A randomized controlled study

Clinical Medicine | 更新时间：2025-12-30

- Impact of compound nutritional preparations on clinical prognosis of patients undergoing cardiovascular surgery: A randomized controlled study
- Journal of Army Medical University Vol. 47, Issue 24, Pages: 3089-3101(2025)
- 作者机构：
  
  1.陆军军医大学（第三军医大学）第二附属医院，营养科，重庆
  2.陆军军医大学（第三军医大学）第二附属医院，心血管外科，重庆
  3.陆军军医大学（第三军医大学）军事预防医学系营养与食品安全研究中心，重庆市医学营养研究中心，营养与健康重庆市重点实验室，重庆
- 作者简介：
  
  MI Mantian，E-mail： mantian_mi@tmmu.edu.cn
  WANG Jian，E-mail： wangjian_xq@tmmu.edu.cn
- 基金信息：
  
  the Major Project of the Fourteeth Five-Year Plan(2022)
- DOI：10.16016/j.2097-0927.202510016
  CLC： R181.32;R459.3;R654.07
- Received：11 October 2025，
  
  Revised：2025-12-10，
  
  Published：30 December 2025
- 稿件说明：
移动端阅览
辛文彬，白倩，倪向敏，等.复方营养制剂干预对心血管外科手术患者临床预后影响的随机对照研究［J］.陆军军医大学学报，2025，47（24）：3089-3101.DOI：10.16016/j.2097-0927.202510016.

XIN W B，BAI Q，NI X M，et al.Impact of compound nutritional preparations on clinical prognosis of patients undergoing cardiovascular surgery： A randomized controlled study［J］.J Army Med Univ，2025，47（24）：3089-3101.DOI：10.16016/j.2097-0927.202510016.
辛文彬，白倩，倪向敏，等.复方营养制剂干预对心血管外科手术患者临床预后影响的随机对照研究［J］.陆军军医大学学报，2025，47（24）：3089-3101.DOI：10.16016/j.2097-0927.202510016. DOI：

XIN W B，BAI Q，NI X M，et al.Impact of compound nutritional preparations on clinical prognosis of patients undergoing cardiovascular surgery： A randomized controlled study［J］.J Army Med Univ，2025，47（24）：3089-3101.DOI：10.16016/j.2097-0927.202510016. DOI：

摘要

目的

评估复方营养制剂对心血管外科手术患者术后伤口愈合、免疫功能、炎症反应、营养状况及肠屏障功能的影响，为创伤患者快速康复提供新的营养干预策略。

方法

将2024年9月至2025年1月在陆军军医大学第二附属医院心血管外科拟行开放性手术治疗且符合标准的65例患者采用密封信封法随机分为试验组（

=32）和对照组（

=33）。术后第1天起，两组均接受7天等能量等蛋白肠内营养支持，对照组予常规配方，试验组予含复方营养制剂配方。于术后第7天和第14天采用REEDA评分法评估伤口愈合情况。术前、术后第3天和第7天检测中性粒细胞与淋巴细胞比值（neutrophil-to-lymphocyte ratio，NLR）、白细胞（white blood cells，WBC）、C-反应蛋白（C-reactive protein，CRP）、肿瘤坏死因子-α（tumor necrosis factor-α，TNF-α）及白介素-6（interleukin-6，IL-6）以评估机体炎症反应及应激状况；检测T淋巴细胞（CD3

、CD4

、CD8

）及血清免疫球蛋白A（immunoglobulin A，IgA）、免疫球蛋白G（immunoglobulin G，IgG）、免疫球蛋白M（immunoglobulin M，IgM）以评估患者免疫功能；检测血清白蛋白（albumin，ALB）、前白蛋白（prealbumin，PA）、总蛋白（total protein，TP）以评估患者营养状况；检测血清二胺氧化酶（diamine oxidase，DAO）、内毒素（lipopolysaccharide，LPS）及D-乳酸以评估患者肠屏障功能；术前及术后第7天行体成分分析，定量评估患者脂肪、肌肉等组织成分的分布与比例；比较2组患者术后感染性并

发症发生率及术后住院时间。

结果

最终60例完成研究（试验组和对照组各30例）， 2组基线资料差异均无统计学意义（

0.05）。与对照组相比，试验组术后REEDA评分、术后感染性并发症发生率及住院时间显著降低（

0.05），骨骼肌质量指数（skeletal muscle mass index，SMI）、50 kHz全身相位角显著升高（

0.05）。术后第3天，各指标组间差异均无显著统计学意义（

0.05）；术后第7天，试验组CD3

、CD4

T细胞计数及血清PA水平显著高于对照组（

0.05），且CD3

、CD4

、CD8

T细胞计数及IgA存在显著组别×时间交互效应（

0.05）。试验组NLR、CRP、TNF-α、IL-6、DAO、LPS、D-乳酸显著低于对照组（

0.05），且NLR、CRP、IL-6、DAO、D-乳酸存在显著的组别×时间交互效应（

0.05）。

结论

该复方营养制剂能促进心血管外科开放性手术患者伤口愈合，改善免疫功能及营养状况，减轻炎症反应，保护肠屏障功能，促进患者术后康复。

Abstract

Objective

To evaluate the effects of a compound nutritional preparation on postoperative wound healing

immune function

inflammatory response

nutritional status

and intestinal barrier function in patients after cardiovascular surgery

so as to provide a new nutritional intervention strategy for rapid recovery of trauma patients.

Methods

From September 2024 to January 2025

65 eligible patients scheduled for open cardiovascular surgery at the Second Affiliated Hospital of Army Medical University were recruited

and randomly assigned

via

sealed envelopes to either an experimental group (

=32) or a control group (

=33). From the first day after operation

both groups received isocaloric and isonitrogenous enteral nutritional support for 7 d

and the control group was given a standard formula

while the experimental group took the compound nutritional preparation. Wound healing was assessed with REEDA scale on postoperative days 7 and 14. Inflammatory markers

including the neutrophil-to-lymphocyte ratio (NLR)

white blood cell (WBC) count

C-reactive protein (CRP)

TNF-α and IL-6 were measured preoperatively

and on postoperative days 3 and 7. Immune function was evaluated by T-lymphocyte subsets (CD3

CD4

CD8

) and serum immunoglobulins (IgA

IgG

IgM). Nutritional status was assessed

via

serum albumin (ALB)

prealbumin (PA)

and total protein (TP). Intestinal barrier function was indicated by serum levels of diamine oxidase (DAO)

lipopolysaccharide (LPS) and D-lactate. Body composition analysis was performed preoperatively and on postoperative day 7. Incidence of postoperative infectious complications and length of hospital stay were compared between the 2 groups.

Results

Finally

60 patients completed the whole study

with 30 participants in each group. No significant differences were found in baseline indicators between the 2 groups. When compared with the control group

the experimental group exhibited significantly lower postoperative REEDA scores

reduced incidence of infectious complications

and shorter length of hospital stay (

0.05)

along with obviously higher skeletal muscle mass index (SMI) and 50 kHz whole-body phase angle (

0.05). On postoperative day 3

there were no significant differences in above indicator between the 2 groups (

0.05). On postoperative day 7

notably higher CD3⁺ and CD4⁺ T-cell counts and serum PA levels were observed in the experimental group than the control group (

0.05). Significant group × time interactions were observed in CD3⁺

CD4⁺

and CD8⁺ T-cell counts and IgA level (

0.05). Additionally

the experimental group had remarkably lower levels of NLR

CRP

TNF-α

IL-6

DAO

LPS

and D-lactate (

0.05)

with significant group×time interactions for NLR

CRP

IL-6

DAO

and D-lactate (

0.05). There existed significant group×time interactions in NLR

CRP

IL-6

DAO

and D-lactate.

Conclusion

The compound nutritional preparation can promote wound healing

improve immune function and nutritional status

attenuate the inflammatory response

protect intestinal barrier function

and thereby facilitate postoperative recovery in patients undergoing open cardiovascular surgery.

关键词

Keywords

references

SALAZAR MAYA Á M . Nursing care during the perioperative within the surgical context ［J］. Invest Educ Enferm ， 2022 ， 40 （ 2 ）： e02 . DOI： 10.17533/udea.iee.v40n2e02 http://dx.doi.org/10.17533/udea.iee.v40n2e02 .

BLAZEBY J . Bluebelle pilot randomised controlled trial of three wound dressing strategies to reduce surgical site infection in primary surgical wounds ［J］. BMJ Open ， 2020 ， 10 （ 1 ）： e030615 . DOI： 10.1136/bmjopen-2019-030615 http://dx.doi.org/10.1136/bmjopen-2019-030615 .

ZHANG X F ， YANG Y Y ， LIU P Z ， et al . Identification of risk factors and phenotypes of surgical site infection in patients after abdominal surgery ［J］. Ann Surg ， 2023 ， 278 （ 5 ）： e988 - e994 . DOI： 10.1097/SLA.0000000000005939 http://dx.doi.org/10.1097/SLA.0000000000005939 .

KRAFT F ， SCHMIDT C ， VAN AKEN H ， et al . Inflammatory response and extracorporeal circulation ［J］. Best Pract Res Clin Anaesthesiol ， 2015 ， 29 （ 2 ）： 113 - 123 . DOI： 10.1016/j.bpa.2015.03.001 http://dx.doi.org/10.1016/j.bpa.2015.03.001 .

CHOUCHANI E T ， PELL V R ， JAMES A M ， et al . A unifying mechanism for mitochondrial superoxide production during ischemia-reperfusion injury ［J］. Cell Metab ， 2016 ， 23 （ 2 ）： 254 - 263 . DOI： 10.1016/j.cmet.2015.12.009 http://dx.doi.org/10.1016/j.cmet.2015.12.009 .

HALLE D R ， BENHASSEN L L ， SØBERG K L ， et al . Impact of minimal invasive extracorporeal circulation on systemic inflammatory response - a randomized trial ［J］. J Cardiothorac Surg ， 2024 ， 19 （ 1 ）： 418 . DOI： 10.1186/s13019-024-02903-8 http://dx.doi.org/10.1186/s13019-024-02903-8 .

JACOB K A ， BUIJSROGGE M P ， FRENCKEN J F ， et al . White blood cell count and new-onset atrial fibrillation after cardiac surgery ［J］. Int J Cardiol ， 2017 ， 228 ： 971 - 976 . DOI： 10.1016/j.ijcard.2016.11.038 http://dx.doi.org/10.1016/j.ijcard.2016.11.038 .

CHU Y L ， KONG J ， XU J ， et al . Role of nutritional support in nursing practice for improving surgical site wound healing in patients post-surgery with risk of pressure ulcers ［J］. Int Wound J ， 2024 ， 21 （ 4 ）： e14855 . DOI： 10.1111/iwj.14855 http://dx.doi.org/10.1111/iwj.14855 .

WEIMANN A ， BRAGA M ， CARLI F ， et al . ESPEN practical guideline： Clinical nutrition in surgery ［J］. Clin Nutr ， 2021 ， 40 （ 7 ）： 4745 - 4761 . DOI： 10.1016/j.clnu. 2021.03.031 http://dx.doi.org/10.1016/j.clnu.2021.03.031 .

CRUZAT V ， MACEDO ROGERO M ， NOEL KEANE K ， et al . Glutamine： metabolism and immune function， supplementation and clinical translation ［J］. Nutrients ， 2018 ， 10 （ 11 ）： 1564 . DOI： 10.3390/nu10111564 http://dx.doi.org/10.3390/nu10111564 .

CANÈ S ， GEIGER R ， BRONTE V . The roles of arginases and arginine in immunity ［J］. Nat Rev Immunol ， 2025 ， 25 （ 4 ）： 266 - 284 . DOI： 10.1038/s41577-024-01098-2 http://dx.doi.org/10.1038/s41577-024-01098-2 .

CALDER P C . Omega-3 fatty acids and inflammatory processes： from molecules to man ［J］. Biochem Soc Trans ， 2017 ， 45 （ 5 ）： 1105 - 1115 . DOI： 10.1042/BST20160474 http://dx.doi.org/10.1042/BST20160474 .

PULLAR J M ， CARR A C ， VISSERS M C M . The roles of vitamin C in skin health ［J］. Nutrients ， 2017 ， 9 （ 8 ）： 866 . DOI： 10.3390/nu9080866 http://dx.doi.org/10.3390/nu9080866 .

PETKOVICH M ， CHAMBON P . Retinoic acid receptors at 35 years ［J］. J Mol Endocrinol ， 2022 ， 69 （ 4 ）： T13 - T24 . DOI： 10.1530/JME-22-0097 http://dx.doi.org/10.1530/JME-22-0097 .

TRABER M G . Deciphering the Enigma of the function of alpha-tocopherol as a vitamin ［J］. Free Radic Biol Med ， 2024 ， 221 ： 64 - 74 . DOI： 10.1016/j.freeradbiomed. 2024. 05.028 http://dx.doi.org/10.1016/j.freeradbiomed.2024.05.028 .

SEOK H . Selenium-stimulated exosomes enhance wound healing by modulating inflammation and angiogenesis ［J］. Int J Mol Sci ， 2022 ， 23 （ 19 ）： 11543 . DOI： 10.3390/ijms231911543 http://dx.doi.org/10.3390/ijms231911543 .

LIN P H ， SERMERSHEIM M ， LI H C ， et al . Zinc in wound healing modulation ［J］. Nutrients ， 2017 ， 10 （ 1 ）： 16 . DOI： 10.3390/nu10010016 http://dx.doi.org/10.3390/nu10010016 .

MARTINDALE R G . Novel nutrition strategies to enhance recovery after surgery ［J］. JPEN J Parenter Enteral Nutr ， 2023 ， 47 （ 4 ）： 476 - 481 . DOI： 10.1002/jpen.2485 http://dx.doi.org/10.1002/jpen.2485 .

中华医学会肠外肠内营养学分会，中国医药教育协会加速康复外科专业委员会 . 加速康复外科围术期营养支持中国专家共识（2019版）［J］. 中华消化外科杂志， 2019 ， 18 （ 10 ）： 897 - 902 . DOI： 10.3760/cma.j.issn.1673-9752.2019.10.001 http://dx.doi.org/10.3760/cma.j.issn.1673-9752.2019.10.001 .

Chinese Society for Parenteral and Enteral Nutrition ， Enhanced Recovery After Surgery Committee of China Medicine Education Association . Chinese expert consensus on perioperative nutritional support in enhanced recovery after surgery （2019 edition）［J］. Chin J Dig Surg ， 2019 ， 18 （ 10 ）： 897 - 902 . DOI： 10.3760/cma.j.issn.1673-9752.2019.10.001 http://dx.doi.org/10.3760/cma.j.issn.1673-9752.2019.10.001 .

BAO L Z ， CHU R Z ， ZHANG L L ， et al . The impact of early nutritional support on postoperative wound healing in patients with complex fractures： a meta-analysis review ［J］. Int Wound J ， 2024 ， 21 （ 3 ）： e14782 . DOI： 10.1111/iwj.14782 http://dx.doi.org/10.1111/iwj.14782 .

RAJAB T K ， VOGEL A D ， TUREK J W . Partial heart transplant in congenital cardiac surgery ［J］. JAMA Surg ， 2024 ， 159 （ 9 ）： 1085 - 1086 . DOI： 10.1001/jamasurg. 2024. 1567 http://dx.doi.org/10.1001/jamasurg.2024.1567 .

辛文彬，白倩，倪向敏，等 . 一种复方营养制剂对大鼠急性创伤后伤口愈合的影响研究［J］. 陆军军医大学学报， 2025 ， 47 （ 6 ）： 506 - 518 . DOI： 10.16016/j.2097-0927.202412081 http://dx.doi.org/10.16016/j.2097-0927.202412081 .

XIN W B ， BAI Q ， NI X M ， et al . Effect of a compound nutrition preparation on wound healing after acute trauma in rats ［J］. J Army Med Univ ， 2025 ， 47 （ 6 ）： 506 - 518 . DOI： 10.16016/j.2097-0927.202412081 http://dx.doi.org/10.16016/j.2097-0927.202412081 .

SAGHAFI F ， RAMEZANI V ， JAFARI-NEDOOSHAN J ， et al . Efficacy of topical atorvastatin-loaded emulgel and nano-emulgel 1% on post-laparotomy pain and wound healing： a randomized double-blind placebo-controlled clinical trial ［J］. Int Wound J ， 2023 ， 20 （ 10 ）： 4006 - 4014 . DOI： 10.1111/iwj.14289 http://dx.doi.org/10.1111/iwj.14289 .

GRADA A ， PHILLIPS T J . Nutrition and cutaneous wound healing ［J］. Clin Dermatol ， 2022 ， 40 （ 2 ）： 103 - 113 . DOI： 10.1016/j.clindermatol.2021.10.002 http://dx.doi.org/10.1016/j.clindermatol.2021.10.002 .

TORSY T ， TENCY I ， BEECKMAN D ， et al . Effectiveness of glutamine and arginine in wound healing of pressure ulcers： a systematic review protocol ［J］. J Tissue Viability ， 2024 ， 33 （ 2 ）： 239 - 242 . DOI： 10.1016/j.jtv.2024.03.001 http://dx.doi.org/10.1016/j.jtv.2024.03.001 .

CEREDA E ， KLERSY C ， SERIOLI M ， et al . A nutritional formula enriched with arginine， zinc， and antioxidants for the healing of pressure ulcers： a randomized trial ［J］. Ann Intern Med ， 2015 ， 162 （ 3 ）： 167 - 174 . DOI： 10.7326/M14-0696 http://dx.doi.org/10.7326/M14-0696 .

KJAER M ， FREDERIKSEN A K S ， NISSEN N I ， et al . Multinutrient supplementation increases collagen synthesis during early wound repair in a randomized controlled trial in patients with inguinal hernia ［J］. J Nutr ， 2020 ， 150 （ 4 ）： 792 - 799 . DOI： 10.1093/jn/nxz324 http://dx.doi.org/10.1093/jn/nxz324 .

ALAZAWI W ， PIRMADJID N ， LAHIRI R ， et al . Inflammatory and immune responses to surgery and their clinical impact ［J］. Ann Surg ， 2016 ， 264 （ 1 ）： 73 - 80 . DOI： 10.1097/SLA.0000000000001691 http://dx.doi.org/10.1097/SLA.0000000000001691 .

DA SILVA BATISTA E ， NAKANDAKARI S C B R ， RAMOS DA SILVA A S ， et al . Omega-3 pleiad： The multipoint anti-inflammatory strategy ［J］. Crit Rev Food Sci Nutr ， 2024 ， 64 （ 14 ）： 4817 - 4832 . DOI： 10.1080/10408398.2022.2146044 http://dx.doi.org/10.1080/10408398.2022.2146044 .

CAPOROSSI D ， Jr LANCHA A H ， COLETTI D . Inflammation： the beauty or the beast？ vitamins， nutritional supplements， antioxidant therapy， and modulators of inflammation as therapeutic interventions ［J］. Nutrients ， 2024 ， 16 （ 21 ）： 3630 . DOI： 10.3390/nu16213630 http://dx.doi.org/10.3390/nu16213630 .

IWASE H ， KARIYAZONO H ， ARIMA J ， et al . Nutritional effect of oral supplement enriched in ω-3 fatty acids， arginine， RNA on immune response and leukocyte-platelet aggregate formation in patients undergoing cardiac surgery ［J］. Nutr Metab Insights ， 2014 ， 7 ： 39 - 46 . DOI： 10.4137/NMI.S13810 http://dx.doi.org/10.4137/NMI.S13810 .

SVETIKIENE M ， RINGAITIENE D ， VEZELIENE J ， et al . The efficacy of early postoperative enteral immunonutrition on T-lymphocyte count： a randomised control study in low-risk cardiac surgery patients ［J］. Clin Nutr ， 2021 ， 40 （ 2 ）： 372 - 379 . DOI： 10.1016/j.clnu.2020.05.009 http://dx.doi.org/10.1016/j.clnu.2020.05.009 .

MARIK P E ， FLEMMER M . The immune response to surgery and trauma： Implications for treatment ［J］. J Trauma Acute Care Surg ， 2012 ， 73 （ 4 ）： 801 - 808 . DOI： 10.1097/TA.0b013e318265cf87 http://dx.doi.org/10.1097/TA.0b013e318265cf87 .

TANG F ， TIE Y ， TU C Q ， et al . Surgical trauma-induced immunosuppression in cancer： Recent advances and the potential therapies ［J］. Clin Transl Med ， 2020 ， 10 （ 1 ）： 199 - 223 . DOI： 10.1002/ctm2.24 http://dx.doi.org/10.1002/ctm2.24 .

SANDEEP B ， XIAO Z W ， ZHAO F Y ， et al . Role of platelets in acute lung injury after extracorporeal circulation in cardiac surgery patients： a systemic review ［J］. Curr Probl Cardiol ， 2022 ， 47 （ 11 ）： 101088 . DOI： 10.1016/j.cpcardiol.2021.101088 http://dx.doi.org/10.1016/j.cpcardiol.2021.101088 .

ZHU L ， CHENG J ， XIAO F ， et al . Effects of comprehensive nutrition support on immune function， wound healing， hospital stay， and mental health in gastrointestinal surgery ［J］. World J Gastrointest Surg ， 2024 ， 16 （ 12 ）： 3737 - 3744 . DOI： 10.4240/wjgs.v16.i12.3737 http://dx.doi.org/10.4240/wjgs.v16.i12.3737 .

SETH I ， LIM B ， CEVIK J ， et al . Impact of nutrition on skin wound healing and aesthetic outcomes： a comprehensive narrative review ［J］. JPRAS Open ， 2024 ， 39 ： 291 - 302 . DOI： 10.1016/j.jpra.2024.01.006 http://dx.doi.org/10.1016/j.jpra.2024.01.006 .

CARR A ， MAGGINI S . Vitamin C and immune function ［J］. Nutrients ， 2017 ， 9 （ 11 ）： 1211 . DOI： 10.3390/nu9111211 http://dx.doi.org/10.3390/nu9111211 .

WESSELS I ， MAYWALD M ， RINK L . Zinc as a gatekeeper of immune function ［J］. Nutrients ， 2017 ， 9 （ 12 ）： 1286 . DOI： 10.3390/nu9121286 http://dx.doi.org/10.3390/nu9121286 .

SALOMON J ， ERICSSON A ， PRICE A ， et al . Dysbiosis and intestinal barrier dysfunction in pediatric congenital heart disease is exacerbated following cardiopulmonary bypass ［J］. JACC Basic Transl Sci ， 2021 ， 6 （ 4 ）： 311 - 327 . DOI： 10.1016/j.jacbts.2020.12.012 http://dx.doi.org/10.1016/j.jacbts.2020.12.012 .

MA M W ， ZHENG Z C ， ZENG Z Y ， et al . Perioperative enteral immunonutrition support for the immune function and intestinal mucosal barrier in gastric cancer patients undergoing gastrectomy： a prospective randomized controlled study ［J］. Nutrients ， 2023 ， 15 （ 21 ）： 4566 . DOI： 10.3390/nu15214566 http://dx.doi.org/10.3390/nu15214566 .

ZHANG R K ， CHEN Y N ， ZHANG J X ， et al . Elevated serum levels of diamine oxidase， D-lactate and lipopolysaccharides are associated with metabolic-associated fatty liver disease ［J］. Eur J Gastroenterol Hepatol ， 2023 ， 35 （ 1 ）： 94 - 101 . DOI： 10.1097/MEG.0000000000002456 http://dx.doi.org/10.1097/MEG.0000000000002456 .

FU Y W ， WANG Y D ， GAO H ， et al . Associations among dietary omega-3 polyunsaturated fatty acids， the gut microbiota， and intestinal immunity ［J］. Mediators Inflamm ， 2021 ， 2021 ： 8879227 . DOI： 10.1155/2021/8879227 http://dx.doi.org/10.1155/2021/8879227 .

WAN Y ， ZHANG B K . The impact of zinc and zinc homeostasis on the intestinal mucosal barrier and intestinal diseases ［J］. Biomolecules ， 2022 ， 12 （ 7 ）： 900 . DOI： 10.3390/biom12070900 http://dx.doi.org/10.3390/biom12070900 .

WANG P P ， GUO S H . Correlation between Charlson comorbidity index and surgical prognosis in elderly patients with femoral neck fractures： a retrospective study ［J］. BMC Musculoskelet Disord ， 2024 ， 25 （ 1 ）： 678 . DOI： 10.1186/s12891-024-07814-2 http://dx.doi.org/10.1186/s12891-024-07814-2 .

WOODWARD Z K ， SIVASUTHAN G ， ASEERVATHAM R ， et al . Impact of preoperative sarcopenia on survival and postoperative outcomes in esophageal cancer patients undergoing esophagectomy： a single-center retrospective study ［J］. Cureus ， 2025 ， 17 （ 1 ）： e77521 . DOI： 10.7759/cureus.77521 http://dx.doi.org/10.7759/cureus.77521 .

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effect of a compound nutrition preparation on wound healing after acute trauma in rats

Effects of multi-oil fat emulsion injection on liver function, immune function and inflammation in ICU patients

Effects of long-term 2.65 GHz radiofrequency radiation on inflammatory response and intestinal microbiota in mice

Ferrostatin-1 attenuates inflammatory response to hypoxic lung injury at plateau by inhibiting ferroptosis in lung epithelial cells

Effects of low-gluten rice (W0868) feeding on nutritional status and renal function in mice

Related Author

XIN Wenbin

BAI Qian

NI Xiangmin

HUANG Rongjiang

LIANG Xinyu

MI Mantian

WANG Jian

ZHU Wenyi

Related Institution

Nutrition and Food Safety Research Center， Chongqing Medical Nutrition Research Center， Chongqing Key Laboratory of Nutrition and Health， Faculty of Military Preventive Medicine， Army Medical University （Third Military Medical University）

Department of Nutrition， Second Affiliated Hospital， Army Medical University （Third Military Medical University）

Department of Nutrition, Department of Pulmonary and Critical Care Medicine, Second Affiliated Hospital, Army Medical University (Third Military Medical University)

Academy of Military Medical Sciences， Academy of Military Science

School of Animal Science and Technology， Foshan University

⁰