Ophiopogonis polysaccharides inhibit TNF-α/NF-κB/NLRP3 pathway to mitigate submandibular gland inflammation in a Sjögren’s syndrome murine model

HUA Qingni; CHEN Yueyue; WU Suling

doi:10.16016/j.2097-0927.202508016

您当前的位置：

首页 >

文章列表页 >

Ophiopogonis polysaccharides inhibit TNF-α/NF-κB/NLRP3 pathway to mitigate submandibular gland inflammation in a Sjögren’s syndrome murine model

Basic Medicine | 更新时间：2025-12-24

- Ophiopogonis polysaccharides inhibit TNF-α/NF-κB/NLRP3 pathway to mitigate submandibular gland inflammation in a Sjögren’s syndrome murine model
- Journal of Army Medical University Vol. 47, Issue 23, Pages: 2913-2921(2025)
- 作者机构：
  
  1.南京中医药大学养老服务与管理学院，江苏南京
  2.南京市中医院风湿病科，江苏南京
- 作者简介：
  
  WU Suling， E-mail：syf039@njucm.edu.cn
- 基金信息：
  
  the National Natural Science Foundation for Young Scholars of China(82305128);the General Program of Jiangsu Province Science and Technology Development Program （Traditional Chinese Medicine）(MS2023050)
- DOI：10.16016/j.2097-0927.202508016
  CLC： R285.5;R364.5;R593.2
- Received：06 August 2025，
  
  Revised：2025-11-26，
  
  Accepted：27 November 2025，
  
  Published：15 December 2025
- 稿件说明：
移动端阅览
华庆妮，陈月月，吴素玲.麦冬多糖通过抑制TNF-α/NF-κB/NLRP3信号通路减轻干燥综合征小鼠颌下腺炎症［J］.陆军军医大学学报，2025，47（23）：2913-2921.DOI：10.16016/j.2097-0927.202508016.

HUA Q N，CHEN Y Y，WU S L.Ophiopogonis polysaccharides inhibit TNF-α/NF-κB/NLRP3 pathway to mitigate submandibular gland inflammation in a Sjögren’s syndrome murine model［J］.J Army Med Univ，2025，47（23）：2913-2921.DOI：10.16016/j.2097-0927.202508016.
华庆妮，陈月月，吴素玲.麦冬多糖通过抑制TNF-α/NF-κB/NLRP3信号通路减轻干燥综合征小鼠颌下腺炎症［J］.陆军军医大学学报，2025，47（23）：2913-2921.DOI：10.16016/j.2097-0927.202508016. DOI：

HUA Q N，CHEN Y Y，WU S L.Ophiopogonis polysaccharides inhibit TNF-α/NF-κB/NLRP3 pathway to mitigate submandibular gland inflammation in a Sjögren’s syndrome murine model［J］.J Army Med Univ，2025，47（23）：2913-2921.DOI：10.16016/j.2097-0927.202508016. DOI：

摘要

目的

探究麦冬多糖（

Ophiopogon japonicus

polysaccharides， OJP）对干燥综合征（Sjögren’s syndrome，SS）小鼠颌下腺炎症的抗炎作用及其对肿瘤坏死因子-α（tumor necrosis factor，TNF-α）/核因子-κB（nuclear factor kappa-B，NF-κB）/NOD样受体热蛋白结构域 3（NOD like receptor family pyrin domain containing 3，NLRP3）通路的影响。

方法

①8只C57BL/6J小鼠设为空白组（Control组），32只C57BL/6J小鼠采用免疫诱导法建立SS模型，采用随机数字法分为（

=8）：模型组（SS组）、低剂量麦冬多糖组［OJP（10 mg/kg）组］、高剂量麦冬多糖组［OJP（20 mg/kg）组］、羟氯喹组（Hyd组）。Control组、SS组灌服生理盐水，OJP（10 mg/kg）和OJP（20 mg/kg）组分别灌胃0.2 mL的10、20 mg/kg OJP溶液，Hyd组灌胃给予0.2 mL的100 mg/kg羟氯喹溶液，每日1次，共4周。测量小鼠饮水量及唾液流率，采用ELISA法检测小鼠血清中白细胞介素-6（interleukin-6，IL-6）、白细胞介素-1β（interleukin-1β，IL-1β）、TNF-α炎症因子指标，HE染色观察各组小鼠颌下腺组织病理的改变，Western blot检测TNF-α/NF-κB/NLRP3通路相关蛋白的表达，免疫荧光法检测TNF-α、NLRP3蛋白表达。②将RAW264.7巨噬细胞分为空白对照组（Control组）、模型组（SS组）、麦冬多糖低剂量组（OJP1组）、麦冬多糖中剂量组（OJP2组）、麦冬多糖高剂量组（OJP4组），培养24 h后，去除培养基，Control组加入2 mL的DMEM完全培养基，SS组加入2 mL的含16 μg 脂多糖（lipopolysaccharides，LPS）的DMEM完全培养基，OJP不同剂量组分别加入2 mL的含16 μg LPS及浓度为1、2或4 mg/mL OJP的DMEM完全培养基。采用ELISA法检测炎症因子指标，Western blot检测TNF-α/NF-κB/NLRP3通路相关蛋白的表达，免疫荧光法检测TNF-α蛋白表达。

结果

①与空白组比较，SS组小鼠饮水量增加，唾液流率减少（

0.05），血清中炎症因子IL-1β、IL-6及TNF-α增多（

0.01），颌下腺组织HE染色显示病理损伤加重，NLRP3、凋亡相关斑点样蛋白（apoptosis-associated speck-like protein containing a CARD，ASC）、半胱天冬酶-1（cysteinyl aspartate specific proteinase，Caspase-1）、IL-1β、TNF-α、肿瘤坏死因子受体1（TNF receptor type 1，TNFR1）/甘油醛-3-磷酸脱氢酶（glyceraldehyde-3-phosphate dehydrogena

se ，GAPDH）及磷酸化NF-κB p65（p-NF-κB p65）/NF-κB p65升高（

0.01），免疫荧光结果显示TNF-α、NLRP3蛋白的表达升高。与SS组相比，Hyd组、OJP各剂量组小鼠饮水量减少，唾液流率增加（

0.01）、血清中炎症因子IL-1β、IL-6及TNF-α不同程度减少、颌下腺病理损伤均有减轻、Western blot结果显示NLRP3、ASC、Caspase-1、IL-1β、TNF-α、TNFR1/GAPDH及p-NF-κB p65/NF-κB p65蛋白表达降低（

0.01）、免疫荧光结果显示TNF-α、NLRP3蛋白的表达均有降低。②与单纯用LPS处理的巨噬细胞相比，经OJP干预后的细胞中的炎症因子、NLRP3、ASC、Caspase-1、IL-1β、TNF-α、TNFR1/GAPDH及p-NF-κB p65/NF-κB p65均有所降低（

0.01）。

结论

OJP可能通过抑制TNF-α/NF-κB/NLRP3信号通路激活达到抗炎作用，以此减轻SS小鼠炎症反应。

Abstract

Objective

To investigate the anti-inflammatory effects of

Ophiopogon japonicus

polysaccharides (OJP) on submandibular gland inflammation in a mouse model of Sjögren’s syndrome (SS) and its impact on the tumor necrosis factor-α (TNF-α)/nuclear factor kappa-B (NF-κB)/NOD-like receptor family pyrin domain containing 3 (NLRP3) signaling pathway.

Methods

① Eight C57BL/6J mice served as the control group (Control group)

while 32 C57BL/6J mice were subjected to immune induction to establish the SS model and then randomly divided into 4 groups (

=8 each): model group (SS group)

low-dose OJP group [OJP (10 mg/kg) group

]

high-dose OJP group [OJP (20 mg/kg) group

]

and hydroxychloroquine group (Hyd group). The Control and SS groups received intragastric administration of saline

the OJP (10 mg/kg) and OJP (20 mg/kg) groups received 0.2 mL of OJP solution at 10 mg/kg or 20 mg/kg

respectively

and the Hyd group received 0.2 mL of hydroxychloroquine solution at 100 mg/kg

once daily for 4 weeks. Water consumption and salivary flow rate were measured. Serum levels of inflammatory cytokines interleukin-6 (IL-6)

interleukin-1β (IL-1β)

and TNF-α were detected by ELISA. Pathological changes in submandibular gland tissue were observed by HE staining. Protein expression related to the TNF-α/NF-κB/NLRP3

pathway was assessed by Western blot

and TNF-α and NLRP3 protein expression was detected by immunofluorescence. ② RAW264.7 macrophages were divided into blank control group (Control group)

model group (SS group)

low-dose OJP group (OJP1 group)

medium-dose OJP group (OJP2 group)

and high-dose OJP group (OJP4 group). After 24 hours of culture

the medium was removed; the Control group received 2 mL of complete DMEM medium

the SS group received 2 mL of complete DMEM medium containing 16 μg LPS

and the different OJP dose groups received 2 mL of complete DMEM medium containing 16 μg LPS plus OJP at concentrations of 1

or 4 mg/mL

respectively. Inflammatory cytokine levels were measured by ELISA

TNF-α/NF-κB/NLRP3 pathway-related protein expression was detected by Western blot

and TNF-α protein expression was detected by immunofluorescence.

Results

① Compared with the Control group

the SS group showed increased water consumption and decreased salivary flow rate (

0.05)

elevated serum levels of IL-1β

IL-6

and TNF-α (

0.01)

aggravated pathological damage observed by HE staining in submandibular glands

and increased expression of NLRP3

apoptosis-associated speck-like protein containing a CARD (ASC)

cysteinyl aspartate specific proteinase (Caspase-1)

IL-1β

TNF-α

TNF receptor type 1 (TNFR1)/glyceraldehyde-3-phosphate dehydrogenase (GAPDH)

and phosphorylated NF-κB p65 (p-NF-κB p65)/NF-κB p65 (

0.01)

with immunofluorescence also showing elevated TNF-α and NLRP3 protein expression. Compared with the SS group

the Hyd group and both OJP dose groups exhibited decreased water consumption

increased salivary flow rate (

0.01)

reduced serum levels of IL-1β

IL-6

and TNF-α

alleviated submandibular gland pathological damage

decreased expression of NLRP3

ASC

Caspase-1

IL-1β

TNF-α

TNFR1/GAPDH

and p-NF-κB p65/NF-κB p65 proteins by Western blotting (

0.01)

and reduced

TNF-α and NLRP3 protein expression by immunofluorescence. ② Compared with macrophages treated solely with LPS

those treated with OJP intervention showed reduced levels of inflammatory cytokines and decreased expression of NLRP3

ASC

Caspase-1

IL-1β

TNF-α

TNFR1/GAPDH

and p-NF-κB p65/NF-κB p65 (

0.01).

Conclusion

OJP may exert anti-inflammatory effects by inhibiting the activation of the TNF-α/NF-κB/NLRP3 signaling pathway

thereby alleviating the inflammatory response in SS mice.

关键词

Keywords

references

孙思凌 . 益气养阴通络方治疗气阴两虚型干燥综合征临床疗效观察及对NLRP3/Caspase-1/GSDMD信号轴的影响［D］. 合肥：安徽中医药大学， 2023 . DOI： 10.26922/d.cnki.ganzc.2023.000567 http://dx.doi.org/10.26922/d.cnki.ganzc.2023.000567 .

SUN S L . Clinicai observation of Yiqi Yangyin Tongluo recipe in the treatment of Sjögren’s syndrome of deficiency of both qi and Yin and its effect on NLRP3/caspase-1/GSDMD signal axis ［D］. Hefei ： Anhui University of Chinese Medicine ， 2023 . DOI： 10.26922/d.cnki.ganzc.2023.000567 http://dx.doi.org/10.26922/d.cnki.ganzc.2023.000567 .

XUAN J X ， JI Z Q ， WANG B ， et al . Serological evidence for the association between Epstein-Barr virus infection and Sjögren’s syndrome ［J］. Front Immunol ， 2020 ， 11 ： 590444 . DOI： 10.3389/fimmu.2020.590444 http://dx.doi.org/10.3389/fimmu.2020.590444 .

刘文靖，武诗雅，刘瑞华，等 . 干燥综合征中医治疗优势评价方法学探讨［J］. 中国实验方剂学杂志， 2024 ， 30 （ 1 ）： 192 - 197 . DOI： 10.13422/j.cnki.syfjx.20240495 http://dx.doi.org/10.13422/j.cnki.syfjx.20240495 .

LIU W J ， WU S Y ， LIU R H ， et al . Methodological evaluation of advantages of traditional Chinese medicine treatment of Sjögren’s syndrome ［J］. Chin J Exp Tradit Med Formulae ， 2024 ， 30 （ 1 ）： 192 - 197 . DOI： 10.13422/j.cnki.syfjx.20240495 http://dx.doi.org/10.13422/j.cnki.syfjx.20240495 .

陶依凤，李成荫，汪悦，等 . 麦冬多糖对NOD小鼠颌下腺AQP5和VIP mRNA表达的影响［J］. 时珍国医国药， 2014 ， 25 （ 9 ）： 2072 - 2074 .. DOI： 10.3969/j.issn.1008-0805.2014.09.009 http://dx.doi.org/10.3969/j.issn.1008-0805.2014.09.009 .

TAO Y F ， LI C Y ， WANG Y ， et al . Effects of Ophiopogon japonicus on expression of NOD mice submandibular gland AQP5and VIPmRNA ［J］. Lishizhen Med Mater Med Res ， 2014 ， 25 （ 9 ）： 2072 - 2074 .. DOI： 10.3969/j.issn.1008-0805.2014.09.009 http://dx.doi.org/10.3969/j.issn.1008-0805.2014.09.009 .

王梦洁 . 清燥布津汤治疗干燥综合征阴虚燥毒证的临床观察及其调节炎症微环境的机制研究［D］. 济南：山东中医药大学， 2024 . DOI： 10.27282/d.cnki.gsdzu.2024.000283 http://dx.doi.org/10.27282/d.cnki.gsdzu.2024.000283 .

WANG M J . Clinical observation of Qingzao Bujin Tang inthe treatment of Sjögren’s syndrome of Yin deficiency and dryness toxin syndrome and its mechanism for regulating theinflammatory microenvironment ［D］. Jinan ： Shandong University of Traditional Chinese Medicine ， 2024 . DOI： 10.27282/d.cnki.gsdzu.2024.000283 http://dx.doi.org/10.27282/d.cnki.gsdzu.2024.000283 .

陈慧敏，周全，杨瑞祥，等 . 增液润燥汤对干燥综合征小鼠颌下腺相关mRNA和蛋白及外周血Th17/Treg表达的影响［J］. 中国中医药信息杂志， 2024 ， 31 （ 9 ）： 117 - 123 . DOI： 10.19879/j.cnki.1005-5304.202312420 http://dx.doi.org/10.19879/j.cnki.1005-5304.202312420 .

CHEN H M ， ZHOU Q ， YANG R X ， et al . Effects of Zengye Runzao decoction on submandibular gland related mRNAs， proteins and Th17/Treg in peripheral blood of mice with Sjögren’s syndrome ［J］. Chin J Inf Tradit Chin Med ， 2024 ， 31 （ 9 ）： 117 - 123 . DOI： 10.19879/j.cnki.1005-5304.202312420 http://dx.doi.org/10.19879/j.cnki.1005-5304.202312420 .

ALQUÉZAR C ， DE LA ENCARNACIÓN A ， MORENO F ， et al . Progranulin deficiency induces overactivation of WNT5A expression via TNF-α/NF-κB pathway in peripheral cells from frontotemporal dementia-linked granulin mutation carriers ［J］. J Psychiatry Neurosci ， 2016 ， 41 （ 4 ）： 225 - 239 . DOI： 10.1503/jpn.150131 http://dx.doi.org/10.1503/jpn.150131 .

韵成才，雍文兴 . TNF-α/NF-κB信号通路在慢性阻塞性肺疾病中的作用及中医药调控研究进展［J］. 临床医学研究与实践， 2024 ， 9 （ 7 ）： 7 - 10 . DOI： 10.19347/j.cnki.2096-1413.202407002 http://dx.doi.org/10.19347/j.cnki.2096-1413.202407002 .

YUN C C ， YONG W X . Research progress on the role of TNF-α/NF-κB signaling pathway in chronic obstructive pulmonary disease and regulation of traditional Chinese medicine ［J］. Clin Res Pract ， 2024 ， 9 （ 7 ）： 7 - 10 . DOI： 10.19347/j.cnki.2096-1413.202407002 http://dx.doi.org/10.19347/j.cnki.2096-1413.202407002 .

XUE K J ， RUAN L Y ， HU J ， et al . Panax notoginseng saponin R1 modulates TNF-α/NF-κB signaling and attenuates allergic airway inflammation in asthma ［J］. Int Immunopharmacol ， 2020 ， 88 ： 106860 . DOI： 10.1016/j.intimp.2020.106860 http://dx.doi.org/10.1016/j.intimp.2020.106860 .

LEE S U ， SUNG M H ， RYU H W ， et al . Verproside inhibits TNF-α-induced MUC5AC expression through supp-ression of the TNF-α /NF-κB pathway in human airway epithelial cells ［J］. Cytokine ， 2016 ， 77 ： 168 - 175 . DOI： 10.1016/j.cyto.2015.08.262 http://dx.doi.org/10.1016/j.cyto.2015.08.262 .

刘姣姣 . 金钗石斛生物碱对脂多糖诱导的BV2细胞NF-κB/NLRP3 通路的作用及作用机制［D］. 遵义：遵义医科大学， 2020 . DOI： 10.27680/d.cnki.gzyyc.2020.000346 http://dx.doi.org/10.27680/d.cnki.gzyyc.2020.000346 .

LIU J J . Effects and mechanisms of dendorbium Nobile lindl .alkaloids on NF-κB/NLRP3 pathway in lipopolysaccharide-induced BV2［D］. Zunyi ： Zunyi Medcial University ， 2020 . DOI： 10.27680/d.cnki.gzyyc.2020.000346 http://dx.doi.org/10.27680/d.cnki.gzyyc.2020.000346 .

ZAHID A ， LI B F ， KOMBE A J K ， et al . Pharmacological inhibitors of the NLRP3 inflammasome ［J］. Front Immunol ， 2019 ， 10 ： 2538 . DOI： 10.3389/fimmu.2019.02538 http://dx.doi.org/10.3389/fimmu.2019.02538 .

FU J N ， WU H . Structural mechanisms of NLRP3 inflammasome assembly and activation ［J］. Annu Rev Immunol ， 2023 ， 41 ： 301 - 316 . DOI： 10.1146/annurev-immunol-081022-021207 http://dx.doi.org/10.1146/annurev-immunol-081022-021207 .

ZHANG Q ， YANG X R ， DENG Y . Iguratimod alleviates experimental Sjögren’s syndrome by inhibiting NLRP3 inflammasome activation ［J］. Cell Biochem Biophys ， 2024 ， 82 （ 3 ）： 2275 - 2283 . DOI： 10.1007/s12013-024-01337-2 http://dx.doi.org/10.1007/s12013-024-01337-2 .

孙亚磊，郭宇，王欣雨，等 . 异鼠李素调控NLRP3/ASC/Caspase-1轴介导的细胞焦亡减轻急性肺损伤的机制研究［J］. 中国中药杂志， 2025 ， 50 （ 15 ）： 4120 - 4128 . DOI： 10.19540/j.cnki.cjcmm.20250409.702 http://dx.doi.org/10.19540/j.cnki.cjcmm.20250409.702 .

SUN Y L ， GUO Y ， WANG X Y ， et al . Mechanism of isorhamnetin in alleviating acute lung injury by regulating pyroptosis medicated by NLRP3/ASC/caspase-1 axis ［J］. China J Chin Mater Med ， 2025 ， 50 （ 15 ）： 4120 - 4128 . DOI： 10.19540/j.cnki.cjcmm.20250409.702 http://dx.doi.org/10.19540/j.cnki.cjcmm.20250409.702 .

何思慧，张剑勇，贾二涛 . 原发性干燥综合征炎症发病机制［J］. 中国免疫学杂志， 2023 ， 39 （ 12 ）： 2679 - 2683，封 3 . DOI： 10.3969/j.issn.1000-484X.2023.12.037 http://dx.doi.org/10.3969/j.issn.1000-484X.2023.12.037 .

HE S H ， ZHANG J Y ， JIA E T . Inflammatory pathogenesis of primary Sjögren’s syndrome ［J］. Chin J Immunol ， 2023 ， 39 （ 12 ）： 2679 - 2683，封 3 . DOI： 10.3969/j.issn.1000-484X.2023.12.037 http://dx.doi.org/10.3969/j.issn.1000-484X.2023.12.037 .

沙明慧 . 麦冬多糖基于TLR4/MyD88/NF-κB信号通路调控干燥综合征颌下腺炎性微环境的机制［D］. 南京：南京中医药大学， 2019 .

SHA M H . Mechanism of Ophiopogon japonicus polysaccharide based on TLR4/MyD88/NF-κB signaling pathway regulating inflammatory microenvironment of submandibular gland in Sjögren’s syndrome ［D］. Nanjing ： Nanjing University of Chinese Medicine ， 2019 .

刘姝琳，魏静，朱宝行，等 . 植物源性免疫刺激分子麦冬皂苷的免疫增强效应及初步机制［J］. 陆军军医大学学报， 2025 ， 47 （ 4 ）： 350 - 359 . DOI： 10.16016/j.2097-0927.202412021 http://dx.doi.org/10.16016/j.2097-0927.202412021 .

LIU S L ， WEI J ， ZHU B H ， et al . Immune-enhancing effect and mechanism of natural plant-derived immunostimulatory molecule ophiopogonin ［J］. J Army Med Univ ， 2025 ， 47 （ 4 ）： 350 - 359 . DOI： 10.16016/j.2097-0927.202412021 http://dx.doi.org/10.16016/j.2097-0927.202412021 .

刘鹏，孙一丹，王梓霖，等 . 中药麦冬对干燥综合征作用的研究进展［J］. 吉林医学， 2017 ， 38 （ 4 ）： 773 - 775 . DOI： 10.3969/j.issn.1004-0412.2017.04.080 http://dx.doi.org/10.3969/j.issn.1004-0412.2017.04.080 .

LIU P ， SUN Y D ， WANG Z L ， et al . Research progress on the effect of Ophiopogon japonicus on Sjögren’s syndrome ［J］. Jilin Med J ， 2017 ， 38 （ 4 ）： 773 - 775 . DOI： 10.3969/j.issn.1004-0412.2017.04.080 http://dx.doi.org/10.3969/j.issn.1004-0412.2017.04.080 .

周梦玲 . 基于TLR4/MyD88/NF-κB/NLRP3信号通路探讨麦冬多糖调节干燥综合征炎性微环境的机制研究［D］. 南京：南京中医药大学， 2020 . DOI： 10.27253/d.cnki.gnjzu.2020.000718 http://dx.doi.org/10.27253/d.cnki.gnjzu.2020.000718 .

ZHOU M L . Mechanism of Ophiopogon japonicus polysaccharide regulating the inflammatory microenvironment of Sjögren’s syndrome based on TLR4/MyD88/NF-κB/NLRP3 signaling pathway ［D］. Nanjing ： Nanjing University of Chinese Medicine ， 2020 . DOI： 10.27253/d.cnki.gnjzu.2020.000718 http://dx.doi.org/10.27253/d.cnki.gnjzu.2020.000718 .

汪洋，张辉，马东波，等 . 麦冬多糖通过Nrf2/HO-1信号通路对肺缺血再灌注损伤大鼠肺组织的保护作用［J］. 郑州大学学报（医学版）， 2023 ， 58 （ 4 ）： 464 - 468 . DOI： 10.13705/j.issn.1671-6825.2020.11.050 http://dx.doi.org/10.13705/j.issn.1671-6825.2020.11.050 .

WANG Y ， ZHANG H ， MA D B ， et al . Protective effects of Ophiopogon polysaccharides via Nrf2/HO-1 pathway on lung ischemia-reperfusion injury rats ［J］. J Zhengzhou Univ Med Sci ， 2023 ， 58 （ 4 ）： 464 - 468 . DOI： 10.13705/j.issn.1671-6825.2020.11.050 http://dx.doi.org/10.13705/j.issn.1671-6825.2020.11.050 .

杨阳，施艳茹，伋琳，等 . 麦冬多糖对衰老大鼠皮肤形态及5-羟色胺表达变化影响的实验研究［J］. 陕西医学杂志， 2022 ， 51 （ 12 ）： 1488 - 1491 . DOI： 10.3969/j.issn.1000-7377.2022.12.005 http://dx.doi.org/10.3969/j.issn.1000-7377.2022.12.005 .

YANG Y ， SHI Y R ， JI L ， et al . Effects of Ophiopogon japonicus polysaccharide on skin morphology and serotonin expression in aging rats ［J］. Shaanxi Med J ， 2022 ， 51 （ 12 ）： 1488 - 1491 . DOI： 10.3969/j.issn.1000-7377.2022.12.005 http://dx.doi.org/10.3969/j.issn.1000-7377.2022.12.005 .

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Role of methyl-CpG-binding domain protein 2 in regulating aquaporin-5 expression in human submandibular gland cells in vitro

Related Author

CHEN Zhonglin

NIE Minhai

JIA Ying

YE Yanyan

DENG Shuting

HUANG Wei

LIU Xuqian

Related Institution

Department of Periodontal Medicine, Affiliated Hospital of Stomatology, Southwest Medical University

Department of Stomatology, First Affiliated Hospital, Army Medical University (Third Military Medical University)

⁰