Special dietary food improves exercise-induced myocardial injury in mice

FENG Xu; MI Mantian; YI Long; WANG Wei; CHEN Dagui; YU Xudong; CHEN Song

doi:10.16016/j.2097-0927.202504004

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Special dietary food improves exercise-induced myocardial injury in mice

Military Medicine | 更新时间：2025-07-14

- Special dietary food improves exercise-induced myocardial injury in mice
- Journal of Army Medical University Vol. 47, Issue 13, Pages: 1413-1419(2025)
- 作者机构：
  
  1.海军军医大学海军特色医学中心，上海
  2.陆军军医大学（第三军医大学）军事预防医学系，重庆
  3.上海大学转化医学研究院，上海
- 作者简介：
  
  CHEN Song， E-mail： chensong529237@163.com
- 基金信息：
- DOI：10.16016/j.2097-0927.202504004
  CLC： R459.3;R542.2;R873
- Received：01 April 2025，
  
  Revised：20 June 2025，
  
  Published：15 July 2025
- 稿件说明：
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冯旭，糜漫天，易龙，等.特殊膳食食品改善小鼠运动性心肌损伤的实验研究［J］.陆军军医大学学报，2025，47（13）：1413-1419.DOI：10.16016/j.2097-0927.202504004.

‍FENG X，MI M T，YI L，et al.Special dietary food improves exercise-induced myocardial injury in mice［J］.J Army Med Univ，2025，47（13）：1413-1419.DOI：10.16016/j.2097-0927.202504004.
冯旭，糜漫天，易龙，等.特殊膳食食品改善小鼠运动性心肌损伤的实验研究［J］.陆军军医大学学报，2025，47（13）：1413-1419.DOI：10.16016/j.2097-0927.202504004. DOI：

‍FENG X，MI M T，YI L，et al.Special dietary food improves exercise-induced myocardial injury in mice［J］.J Army Med Univ，2025，47（13）：1413-1419.DOI：10.16016/j.2097-0927.202504004. DOI：

摘要

目的

探讨骐骥特殊膳食食品对小鼠运动性心肌损伤的保护作用。

方法

通过小鼠跑台实验构建小鼠运动性心肌损伤模型，同时灌胃给予骐骥特殊膳食食品，4周后进行跑台力竭实验，取血检测心肌钙蛋白T（cardiac troponin T， cTnT）、血清肌酸激酶（creatine kinase， CK）和乳酸脱氢酶（lactate dehydrogenase， LDH）。取心肌组织检测超氧化物歧化酶（superoxide dismutase， SOD）和丙二醛（malondialdehyde， MDA）含量。观察心肌病理学改变，透射电镜观察心肌超微结构变化。

结果

力竭训练4周后，与正常组小鼠相比，模型组小鼠血清cTnT、CK、心肌MDA水平显著升高（

0.01），心肌SOD水平显著降低（

0.01）。与模型组相比，高、中、低３个剂量组均可以显著降低力竭运动引起的血清cTnT和心肌MDA升高水平（

0.01），且与正常组相比无显著性差异；３个剂量组均可以显著升高力竭运动引起的心肌SOD降低水平（

0.05），与正常组无显著性差异。组织病理和超微病理检查发现，给药组心肌损伤明显减轻，中剂量组保护效果最优。

结论

骐骥特殊膳食食品对小鼠运动性心肌损伤具有明显的保护作用，其机制可能与抗氧化及减轻氧化应激有关。

Abstract

Objective‍　‍To investigate the protective effects of Qiji Special Dietary Food on exercise-induced myocardial injury in mice. Methods‍　‍An exercise-induced myocardial injury model was established using a treadmill running protocol

and at the same time

the modeled mice were administered Qiji Special Dietary Food

via

oral gavage

followed by a 4-week treadmill exhaustion test. Serum levels of cardiac troponin T (cTnT)

creatine kinase (CK)

and lactate dehydrogenase (LDH) were measured. Myocardial tissues were analyzed for superoxide dismutase (SOD) activity and malondialdehyde (MDA) content. Histopathological alterations and ultrastructural changes in myocardial tissue were evaluated using light microscopy and transmission electron microscopy (TEM). Results‍　‍After 4 weeks of exhaustive training

compared to the control group

the model group exhibited significantly elevated serum cTnT

and myocardial MDA levels (

0.01)

along with reduced myocardial SOD activity (

0.01). Compared to the model group

high-

medium-

and low-dose treatment significantly attenuated the exhaustive exercise-induced increases in serum cTnT level and myocardial MDA content (

0.01)

restoring these indicators to the levels comparable to those of the normal control group (

0.05). Additionally

all treatment gro

ups had markedly increased myocardial SOD activity

with no significant difference from the normal group. Histopathological and ultrastructural analyses revealed markedly alleviated myocardial damage in the treatment groups

with the medium-dose group exhibiting the most pronounced protective effects. Conclusion‍　‍Qiji Special Dietary Food demonstrates significant protective effects against exercise-induced myocardial injury in mice

which maybe associated with its antioxidant activity and mitigation of oxidative stress.

关键词

Keywords

references

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