Relationship between clonal hematopoiesis of indeterminate potential and severity of coronary stenosis in coronary heart disease patients with renal insufficiency

Jialin ZHONG; Ruonan XIAO; Shuting XIANG; Yanpeng YANG; Jun LI; Jun XIAO

doi:10.16016/j.2097-0927.202409009

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Relationship between clonal hematopoiesis of indeterminate potential and severity of coronary stenosis in coronary heart disease patients with renal insufficiency

Clinical Medicine | 更新时间：2026-01-09

- Relationship between clonal hematopoiesis of indeterminate potential and severity of coronary stenosis in coronary heart disease patients with renal insufficiency
- Journal of Army Medical University Vol. 46, Issue 24, Pages: 2765-2771(2024)
- 作者机构：
  
  1.400044 重庆，重庆大学医学院
  2.400014 重庆，重庆市急救医疗中心(重庆大学附属中心医院)心血管内科
  3.400042 重庆，重庆医科大学附属第一医院心血管内科
- 作者简介：
- 基金信息：
  
  the Joint Medical Research Project of Chongqing Science and Technology Commission and Chongqing Health Commission(2023MSXM019);the Studio Construction Fund for Young and Middle-Aged Medical Top Talents of Chongqing(渝卫人〔2023〕10号);the Construction Project for Key Specialty (Discipline) in Public Health of Chongqing(渝卫办发﹝2023﹞81号)
- DOI：10.16016/j.2097-0927.202409009
  CLC： R541.4;R559;R692
- Received：02 September 2024，
  
  Revised：2024-11-07，
  
  Published：30 December 2024
- 稿件说明：
移动端阅览
Jialin ZHONG, Ruonan XIAO, Shuting XIANG, et al. Relationship between clonal hematopoiesis of indeterminate potential and severity of coronary stenosis in coronary heart disease patients with renal insufficiency[J]. Journal of Army Medical University, 2024, 46(24): 2765-2771.
DOI：

Jialin ZHONG, Ruonan XIAO, Shuting XIANG, et al. Relationship between clonal hematopoiesis of indeterminate potential and severity of coronary stenosis in coronary heart disease patients with renal insufficiency[J]. Journal of Army Medical University, 2024, 46(24): 2765-2771. DOI： 10.16016/j.2097-0927.202409009.

摘要

目的

探讨潜能未定的克隆性造血(clonal hematopoiesis of indeterminate potential

CHIP)与肾功能不全的冠状动脉粥样硬化性心脏病(coronary heart disease

CHD)患者冠状动脉狭窄程度的关联。

方法

采用病例-对照研究设计方案

纳入2023年12月至2024年7月在重庆市急救医疗中心(重庆大学附属中心医院)和重庆医科大学附属第一医院心血管内科就诊的肾功能不全的CHD患者70例

根据Gensini评分中位数水平分为Gensini评分 < 44分组(34例)和Gensini评分≥44分组(36例)

根据是否携带CHIP突变分为CHIP组(23例)、非CHIP组(47例)

分别比较组间临床资料的差异。采用二元Logistic回归分析评估CHIP状态与冠脉病变程度的关系。

结果

与Gensini评分

44分组比较

Gensini评分≥44分组具有更高的CHIP携带率(17.6%

47.2%

=0.008)以及NT-proBNP水平(767

3 480 ng/L

=0.039)。二元Logistic回归分析显示

在校正NT-proBNP后

CHIP携带仍与较高的Gensini评分相关(

=3.935

95%

: 1.153~13.435

=0.029)。进一步按CHIP分组结果提示

与非CHIP组患者比较

CHIP组患者具有较高的Gensini评分(48

=0.004)、更高的冠脉3支血管病变比例(52.2%

25.5%

=0.040)和较低的左心室射血分数(55.0%

58.0%

=0.042)。

结论

CHIP是肾功能不全CHD患者严重冠脉病变的独立危险因素。

Abstract

Objective

To investigate the association between clonal hematopoiesis of indeterminate potential (CHIP) and the severity of coronary artery lesions in coronary heart disease (CHD) patients with renal insufficiency.

Methods

A case-control trial was conducted on 70 CHD patients with renal insufficiency admitted in Chongqing Emergency Medical Center (Affiliated Central Hospital of Chongqing University) and Department of Cardiovascular Diseases of the First Affiliated Hospital of Chongqing Medical University from December 2023 to July 2024.According to the median Gensini score

they were classified into the Gensini score

44 grou

p (

=34) and ≥44 group (

=36)

and based on carrying CHIP mutation or not

they were divided into CHIP group (

=23) and non-CHIP group (

=47).The differences in clinical data were compared between the above 2 pair groups respectively.Binary logistic regression analysis was used to assess the relationship between CHIP status and the severity of coronary artery lesions.

Results

Compared with the Gensini score

44 group

the Gensini score ≥44 group had a higher CHIP carriage rate (17.2%

47.6%

=0.008) as well as NT-proBNP level (767

3 480 ng/L

=0.039).Binary logistic regression analysis showed that CHIP status was still associated with higher Gensini scores after adjustment of NT-proBNP (

=3.935

95%

=1.153~13.435

=0.029).Further CHIP grouping results suggested that the patients in the CHIP group had higher Gensini score (48

=0.004)

larger proportion of 3-vessle disease (52.2%

25.5%

=0.040)

and lower left ventricular ejection fraction (55.0%

58.0%

=0.042) than those in the non-CHIP group.

Conclusion

CHIP is an independent risk factor for severe coronary artery disease in CHD patients with renal insufficiency.

关键词

Keywords

references

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