Efficacy of 2 L versus 3 L polyethylene glycol in bowel preparation: a real-world study

LI Jiaojun; TAN Xianhao; ZHANG Chen; LIU Yifeng; JIANG Lin; SUN Xiaobin; SHAN Jing

doi:10.16016/j.2097-0927.202407055

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Efficacy of 2 L versus 3 L polyethylene glycol in bowel preparation: a real-world study

Clinical Medicine | 更新时间：2025-02-26

- Efficacy of 2 L versus 3 L polyethylene glycol in bowel preparation: a real-world study
- Journal of Army Medical University Vol. 47, Issue 3, Pages: 255-261(2025)
- 作者机构：
  
  1.川北医学院临床医学院，四川南充
  2.成都市第三人民医院消化内科，四川成都
  3.西南医科大学临床医学院，四川泸州
- 作者简介：
  
  SHAN Jing， E-mail： tulip-sj@163.com
- 基金信息：
  
  the Scientific Research Project of Chengdu Third People’s Hospital(2023PI21);the Clinical Research Project of Chengdu Third People’s Hospital(CSY-YN-01-2023-049)
- DOI：10.16016/j.2097-0927.202407055
  CLC： R195.1;R574;R981.2
- Received：14 July 2024，
  
  Revised：05 August 2024，
  
  Published：15 February 2025
- 稿件说明：
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‍李蕉君，谭贤豪，张宸，等.在真实世界中使用2 L和3 L聚乙二醇电解质溶液进行肠道准备的效果比较［J］.陆军军医大学学报，2025，47（03）：255-261.DOI：10.16016/j.2097-0927.202407055.

‍LI J J，TAN X H，ZHANG C，et al.Efficacy of 2 L versus 3 L polyethylene glycol in bowel preparation： a real-world study［J］.J Army Med Univ，2025，47（03）：255-261.DOI：10.16016/j.2097-0927.202407055.
‍李蕉君，谭贤豪，张宸，等.在真实世界中使用2 L和3 L聚乙二醇电解质溶液进行肠道准备的效果比较［J］.陆军军医大学学报，2025，47（03）：255-261.DOI：10.16016/j.2097-0927.202407055. DOI：

‍LI J J，TAN X H，ZHANG C，et al.Efficacy of 2 L versus 3 L polyethylene glycol in bowel preparation： a real-world study［J］.J Army Med Univ，2025，47（03）：255-261.DOI：10.16016/j.2097-0927.202407055. DOI：

摘要

目的

比较在真实世界中2 L及3 L聚乙二醇电解质溶液（polyethylene glycol，PEG）的肠道准备效果。

方法

本研究为真实世界环境中单中心的队列研究，研究对象为2023年5-10月在成都市第三人民医院消化内科接受结肠镜检查并使用2 L或3 L PEG进行肠道准备的患者。根据纳排标准，3 L 组共纳入3 700 例，2 L 组共纳入4 684 例。主要结果指标是根据波士顿肠道准备评分（Boston bowel preparation score，BBPS）计算的肠道准备充分率；次要结果包括BBPS分数、息肉检出率（polyp detection rate，PDR）、耐受性、依从性和不良反应。

结果

3 L组的肠道准备充分率为94.35%，高于2 L 组的91.29%（

0.001）；BBPS总分为（6.92±1.06）分，高于2 L 组的（6.81±1.14）分（

0.001）。2组的PDR无统计学差异（

=0.073）。2组患者PEG完成率（

=0.810）、按要求进行低渣饮食（

=0.094）及服用二甲硅油（

=0.072）差异均无统计学意义。3 L组的呕吐率（4.5%

3.2%，

=0.002）、腹部不适率（5.0%

3.9%，

=0.011）和睡眠障碍率（18.0%

14.6%，

0.001）高于2 L组。

结论

在真实世界，2 L PEG是一种安全有效的肠道准备方案。

Abstract

Objective‍

‍To compare the efficacy of 2 L and 3 L polyethylene glycol (PEG) electrolyte solution for bowel preparation in a real-world setting.

Methods

A real-world

single-center cohort study was conducted on the individuals undergoing colonoscopy in Department of Gastroenterology of Chengdu Third People's Hospital between May and October 2023. Based on our inclusion and exclusion criteria

they were given 2 L (n=4 684) and 3 L (n=3 700) PEG electrolyte solution for bowel preparation. The primary outcome indicator was the adequacy of bowel preparation by Boston bowel preparation score (BBPS). Secondary outcome indicators included the BBPS score

polyp detection rate (PDR)

tolerability

compliance

and incidence of adverse events.

Results

‍The adequacy rate of bowel preparation was 94.35% in the 3 L group

significantly higher than that of the 2 L group (91.29%

P<0.001). The 3 L group obtained a higher BBPS score then the 2 L group (6.92±1.06 vs 6.81±1.14

P<0.001). But there was no statistical difference in the PDR between the 2 groups (P=0.073). And the rate of PEG completion (P=0.810)

administration of low residue diet as required (P=0.094) or use of dimethicone (P=0.072) were comparable between the 2 groups. However

the incidences of vomiting (4.5% vs 3.2%

P=0.002)

abdominal discomfort (5.0% vs 3.9%

P=0.011) and sleep disturbance (18.0% vs 14.6%

P<0.001) were obviously higher in the 3 L group than the 2 L group.

Conclusion

In a real-world setting

2 L PEG is a considerably safe and effective regimen for bowel preparation.

关键词

Keywords

references

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