Distribution and antimicrobial resistance in 277 cases with diabetic foot infection

Jiawei LIU; Yuan WANG; Jing XU; Min WANG; Chunlin ZHANG; Qiang TONG

doi:10.16016/j.2097-0927.202405104

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Distribution and antimicrobial resistance in 277 cases with diabetic foot infection

Clinical Medicine | 更新时间：2026-01-09

- Distribution and antimicrobial resistance in 277 cases with diabetic foot infection
- Journal of Army Medical University Vol. 46, Issue 23, Pages: 2655-2660(2024)
- 作者机构：
  
  400037 重庆，陆军军医大学第二附属医院内分泌科
- 作者简介：
- 基金信息：
- DOI：10.16016/j.2097-0927.202405104
  CLC： R372;R587.2;R915
- Received：28 May 2024，
  
  Revised：2024-08-08，
  
  Published：15 December 2024
- 稿件说明：
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Jiawei LIU, Yuan WANG, Jing XU, et al. Distribution and antimicrobial resistance in 277 cases with diabetic foot infection[J]. Journal of Army Medical University, 2024, 46(23): 2655-2660.
DOI：

Jiawei LIU, Yuan WANG, Jing XU, et al. Distribution and antimicrobial resistance in 277 cases with diabetic foot infection[J]. Journal of Army Medical University, 2024, 46(23): 2655-2660. DOI： 10.16016/j.2097-0927.202405104.

摘要

目的

分析糖尿病足感染病原微生物分布和耐药情况。

方法

以横断面调查形式统计2020年1月至2023年1月间我科277例住院糖尿病足患者的病历资料，记录其基本情况、创面特征、病原菌和耐药类型，统计分析病原菌分布、耐药率和多重耐药菌感染的危险因素。

结果

在277例患者中共培养出病原微生物228株，包括革兰阳性菌104株，革兰阴性菌115株，真菌7株，放线菌2株。革兰阴性菌在Wagner分级＞3级和溃疡病程＞30 d的患者中所占比例显著增加。革兰阳性菌对青霉素、红霉素耐药率较高，对万古霉素、利奈唑胺最敏感；革兰阴性菌对三、四代头孢菌素耐药率较低，对碳青霉烯类抗生素最敏感。Wagner分级＞3级和溃疡病程＞30 d是多重耐药菌感染的独立危险因素。

结论

糖尿病足感染病原微生物分布存在异质性，Wagner分级＞3级和病程＞30 d的病例以革兰阴性菌感染率高，多重耐药菌感染风险高，应及时针对性调整治疗方案。

Abstract

Objective

To analyze the distribution and antimicrobial resistance in diabetic foot infection.

Methods

A cross-section survey was conducted on 277 patients with diabetic foot infection admitted in our hospital between January 2020 and January 2023. Their clinical data were collected

and wound characteristics

pathogenic bacteria and drug resistance were analyzed statistically for the distribution of pathogenic bacteria

drug resistance rate

and risk factors for multidrug-resistant bacterial infections.

Results

There were 228 strains of pathogenic microorganisms isolated from the 277 patients

including 104 strains of Gram-positive bacteria

115 strains of Gram-negative bacteria

7 strains of fungi

and 2 strains of actinomycetes. The proportion of Gram-negative bacteria was significantly larger in the patients with Wagner grade >3 and course of ulcers >30 d. The isolated Gram-positive bacteria were highly resistant to penicillin and erythromycin

and most of them were sensitive to vancomycin and linezolid. While the Gram-negative ones were highly resistant to the third- and fourth-generation cephalosporins

and most sensitive to carbapenems. Wagner grade >3 and course of ulcers >30 d were independent risk factors for infection of multidrug-resistant organisms.

Conclusion

There is heterogeneity in the distribution of pathogenic microorganisms in diabetic foot infection. For the patients with Wagner grade >3 and course of ulcers >30 d

they have higher rate of Gram-negative bacterial infection

and are at higher risk of multidrug-resistant bacterial infection

so timely and targeted adjustment should be implemented for their treatment regimens.

关键词

Keywords

references

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