Association of B vitamins with chronic constipation and diarrhea: a cross-sectional study based on data from NHANES

Pei DING; Lin WANG; Yan LI; Yujing ZHANG; Lihua PENG

doi:10.16016/j.2097-0927.202405066

您当前的位置：

首页 >

文章列表页 >

Association of B vitamins with chronic constipation and diarrhea: a cross-sectional study based on data from NHANES

Clinical Medicine | 更新时间：2026-01-09

- Association of B vitamins with chronic constipation and diarrhea: a cross-sectional study based on data from NHANES
- Journal of Army Medical University Vol. 46, Issue 19, Pages: 2241-2248(2024)
- 作者机构：
  
  1.100851 北京，军委训练管理部军事体育训练中心运动医学室
  2.100853 北京，解放军总医院第一医学中心消化内科医学部
  3.100853 北京，解放军医学院
- 作者简介：
- 基金信息：
- DOI：10.16016/j.2097-0927.202405066
  CLC： R181.23;R442.2;R977.22
- Received：17 May 2024，
  
  Revised：2024-07-15，
  
  Published：15 October 2024
- 稿件说明：
移动端阅览
Pei DING, Lin WANG, Yan LI, et al. Association of B vitamins with chronic constipation and diarrhea: a cross-sectional study based on data from NHANES[J]. Journal of Army Medical University, 2024, 46(19): 2241-2248.
DOI：

Pei DING, Lin WANG, Yan LI, et al. Association of B vitamins with chronic constipation and diarrhea: a cross-sectional study based on data from NHANES[J]. Journal of Army Medical University, 2024, 46(19): 2241-2248. DOI： 10.16016/j.2097-0927.202405066.

摘要

目的

探讨B族维生素(维生素B1、B2、B6，烟酸)的摄入量与慢性便秘、慢性腹泻的关系。

方法

合并美国国家健康和营养调查数据库(National Health and Nutrition Examination Survey，NHANES)3个周期(2005-2006年、2007-2008年和2009-2010年)的数据信息进行分析，共纳入13 788名参与者，通过24 h饮食回忆访谈评估维生素B1、B2、B6，烟酸的摄入量。采用多元Logistic回归分析探讨B族维生素与慢性便秘、慢性腹泻的相关性，并进行了分层分析和曲线拟合相关分析。

结果

纳入的受试者中有2 520人(18.28%)存在慢性便秘，2 138人(15.51%)存在慢性腹泻。多元Logistic回归和分层分析结果显示，维生素B1、烟酸、维生素B6的摄入量与慢性便秘、慢性腹泻呈线性相关(

＜0.05)，每日摄入量的增加可降低慢性便秘的发生风险，但会增加慢性腹泻的发生风险(

＜0.05)。

结论

维生素B1、B2、B6，烟酸与慢性便秘、慢性腹泻存在相关性。

Abstract

Objective

To investigate the relationship between daily intake of B vitamins (vitamins B1

B6 and niacin) and chronic constipation and chronic diarrhea.

Methods

Data of 3 durations (2005-2006

2007-2008 and 2009-2010) from National Health and Nutrition Examination Survey (NHANES) database were collected and retrospectively analyzed. For the 13 788 participants

their intake of vitamin B1

and niacin were assessed through a 24-hour dietary recall interview. Multivariate logistic regression analysis was employed to explore the correlation between B vitamins and chronic constipation and chronic diarrhea. Additionally

sensitivity analysis and curve fitting correlation analysis were conducted to further elucidate the observed relationships.

Results

Among the subjects who were enrolled in the study

2 520 (18.28%) were diagnosed with chronic constipation

while 2 138 (15.51%) were diagnosed with chronic diarrhea. Multivariate logistic regression analysis and sensitivity analysis indicated linear correlations between the intake of vitamin B1

niacin and vitamin B6 and the occurrence of chronic constipation and chronic diarrhea. An increase in the daily intake of these nutrients potentially reduced the risk of chronic constipation

but also increased the risk of chronic diarrhea (

0.05).

Conclusion

Daily intake of vitamins B1

B6 and niacin is correlated with the occurrence of chronic constipation and chronic diarrhea.

关键词

Keywords

references

中华医学会外科学分会结直肠外科学组. 中国成人慢性便秘评估与外科处理临床实践指南(2022版)[J]. 中华胃肠外科杂志, 2022, 25(1): 1-9. DOI: 10.3760/cma.j.cn441530-20211126-00477.

Rectal Surgery Group of Surgery Branch of Chinese Medical Association. Clinical practice guideline on the evaluation and management of chronic constipation for Chinese adults(2022 edition)[J]. Chin J Gastrointest Surg, 2022, 25(1): 1-9. DOI: 10.3760/cma.j.cn441530-20211126-00477.

SHARMA A, RAO S S C, KEARNS K, et al . Review article: diagnosis, management and patient perspectives of the spectrum of constipation disorders[J ] . Aliment Pharmacol Ther, 2021, 53(12): 1250-1267. DOI: 10.1111/apt.16369.

SHAHEEN N J, HANSEN R A, MORGAN D R , et al. The burden of gastrointestinal and liver diseases, 2006[J ] . Am J Gastroenterol, 2006, 101(9): 2128-2138. DOI: 10.1111/j.1572-0241.2006.00723.x.

SCHILLER L R, PARDI D S, SELLIN J H. Chronic diarrhea: diagnosis and management[J]. Clin Gastroenterol Hepatol, 2017, 15(2): 182-193. e3. DOI: 10.1016/j.cgh.2016.07.028.

SHANKAR S, DURAIRAJ E. Diet and management of diarrhea[J]. Indian J Pediatr, 2024, 91(6): 590-597. DOI: 10.1007/s12098-023-04737-z.

BERTIN L, ZANCONATO M, CREPALDI M, et al . The role of the FODMAP diet in IBS[J ] . Nutrients, 2024, 16(3): 370. DOI: 10.3390/nu16030370.

SINGH P, MITSUHASHI S, BALLOU S, et al . Demographic and dietary associations of chronic diarrhea in a representative sample of adult s in the United States[J ] . Am J Gastroenterol, 2018, 113(4): 593-600. DOI: 10.1038/ajg.2018.24.

PETERSON C T, RODIONOV D A, OSTERMAN A L, et al . B vitamins and their role in immune regulation and cancer[J ] . Nutrients, 2020, 12(11): 3380. DOI: 10.3390/nu12113380.

ZHUANG M, SHANG W T, MA Q C, et al . Abundance of probiotics and butyrate-production microbiome manages constipation via short-chain fatty acids production and hormones secretion[J ] . Mol Nutr Food Res, 2019, 63(23): e1801187. DOI: 10.1002/mnfr.201801187.

CHEN Y T, WU T, LU W W, et al . Predicting the role of the human gut microbiome in constipation using machine-learning methods: a meta-analysis[J ] . Microorganisms, 2021, 9(10): 2149. DOI: 10.3390/microorganisms9102149.

RINGEL Y. The gut microbiome in irritable bowel syndrome and other functional bowel disorders[J]. Gastroenterol Clin North Am, 2017, 46(1): 91-101. DOI: 10.1016/j.gtc.2016.09.014.

MARTONI C J, SRIVASTAVA S, LEYER G J. Lactobacillus acidophilus DDS-1 and Bifidobacterium lactis UABla-12 improve abdominal pain severity and symptomology in irritable bowel syndrome: randomized controlled trial[J ] . Nutrients, 2020, 12(2): E363. DOI: 10.3390/nu12020363..

ISHAQUE S M, KHOSRUZZAMAN S M, AHMED D S, et al . A randomized placebo-controlled clinical trial of a multi-strain probiotic formulation(Bio-Kult ® ) in the management of diarrhea-predominant irritable bowel syndrome[J ] . BMC Gastroenterol, 2018, 18(1): 71. DOI: 10.1186/s12876-018-0788-9..

PARK J, HOSOMI K, KAWASHIMA H, et al . Dietary vitamin B1 intake influences gut microbial community and the consequent production of short-chain fatty acids[J ] . Nutrients, 2022, 14(10): 2078. DOI: 10.3390/nu14102078.

BOZIC I, LAVRNJA I. Thiamine and benfotiamine: Focus on their therapeutic potential[J]. Heliyon, 2023, 9(11): e21839. DOI: 10.1016/j.heliyon.2023.e21839.

COSTLIOW Z A, DEGNAN P H. Thiamine acquisition strategies impact metabolism and competition in the gut microbe Bacteroides thetaiotaomicron [J ] . mSystems, 2017, 2(5): e00116-e00117. DOI: 10.1128/mSystems.00116-17.

VON MARTELS J Z H, BOURGONJE A R, KLAASSEN M A Y, et al . Riboflavin supplementation in patients with Crohn's disease[the RISE-UP study[J ] . J Crohns Colitis, 2020, 14(5): 595-607. DOI: 10.1093/ecco-jcc/jjz208.

HUANG P, JIANG A Q, WANG X X, et al . NMN maintains intestinal homeostasis by regulating the gut microbiota[J ] . Front Nutr, 2021, 8: 714604. DOI: 10.3389/fnut.2021.714604.

HUANG P, WANG X X, WANG S Y, et al . Treatment of inflammatory bowel disease: Potential effect of NMN on intestinal barrier and gut microbiota[J ] . Curr Res Food Sci, 2022, 5: 1403-1411. DOI: 10.1016/j.crfs.2022.08.011.

KANG K, SUN Y, PAN D, et al . Nicotinamide ameliorates dextran sulfate sodium-induced chronic colitis in mice through its anti-inflammatory properties and modulates the gut microbiota[J ] . J Immunol Res, 2021, 2021: 5084713. DOI: 10.1155/2021/5084713.

PELUSO A A, LUNDGAARD A T, BABAEI P, et al . Oral supplementation of nicotinamide riboside alters intestinal microbial composition in rats and mice, but not humans[J ] . NPJ Aging, 2023, 9(1): 7. DOI: 10.1038/s41514-023-00106-4.

MAYENGBAM S, CHLEILAT F, REIMER R A. Dietary vitamin B6 deficiency impairs gut microbiota and host and microbial metabolites in rats[J]. Biomedicines, 2020, 8(11): 469. DOI: 10.3390/biomedicines8110469.

BALLOU S, KATON J, SINGH P, et al . Chronic diarrhea and con stipation are more common in depressed individuals[J ] . Clin Gastroenterol Hepatol, 2019, 17(13): 2696-2703. DOI: 10.1016/j.cgh.2019.03.046.

RUBIN. Profile: institute for health metrics and evaluation, WA, USA[J]. Lancet, 2017, 389(10068): 493. DOI: 10.1016/S0140-6736(17)30263-5.

BREMNER J D, MOAZZAMI K, WITTBRODT M T, et al . Diet, stress and mental health[J ] . Nutrients, 2020, 12(8): 2428. DOI: 10.3390/nu12082428.

BOTTURI A, CIAPPOLINO V, DELVECCHIO G, et al . The role and the effect of magnesium in mental disorders: a systematic review[J ] . Nutrients, 2020, 12(6): 1661. DOI: 10.3390/nu12061661.

TARLETON E K, LITTENBERG B, MACLEAN C D, et al . Role of magnesium supplementation in the treatment of depression: a randomized clinical trial[J ] . PLoS One, 2017, 12(6): e0180067. DOI: 10.1371/journal.pone.0180067.

TARLETON E K, LITTENBERG B. Magnesium intake and depression in adults[J]. J Am Board Fam Med, 2015, 28(2): 249-256. DOI: 10.3122/jabfm.2015.02.140176.

FIELD D T, CRACKNELL R O, EASTWOOD J R, et al . High-dose Vitamin B6 supplemen tation reduces anxiety and strengthens visual surround suppression[J ] . Hum Psychopharmacol, 2022, 37(6): e2852. DOI: 10.1002/hup.2852.

MENON V, KAR S K, SUTHAR N, et al . Vitamin D and depression: a critical appraisal of the evidence and future directions[J ] . Indian J Psychol Med, 2020, 42(1): 11-21. DOI: 10.4103/IJPSYM.IJPSYM_160_19.

MROWICKA M, MROWICKI J, DRAGAN G, et al . The importance of thiamine(vitamin B 1 ) in humans[J ] . Biosci Rep, 2023, 43(10): BSR20230374. DOI: 10.1042/BSR20230374..

WU Y J, ZHANG L M, LI S Y, et al . Associations of dietary vitamin B 1 , vitamin B2, vitamin B6, and vitamin B 1 2 with the risk of depression: a systematic review and meta-analysis[J ] . Nutr Rev, 2022, 80(3): 351-366. DOI: 10.1093/nutrit/nuab014..

BAJ J, BARGIEŁJ, CABAJ J, et al . Trace elements levels in major depressive disorder-evaluation of potential threats and possible therapeutic approaches[J ] . Int J Mol Sci, 2023, 24(20): 15071. DOI: 10.3390/ijms242015071.

ARÉVALO S P, SCOTT T M, FALCÓN L M, et al . Vitamin B-6 and depressive symptomatology, over time, in older Latino adults[J ] . Nutr Neurosci, 2019, 22(9): 625-636. DOI: 10.1080/1028415X.2017.142 2904.

SCALABRINO G. Vitamin-regulated cytokines and growth factors in the CNS and elsewhere[J]. J Neurochem, 2009, 111(6): 1309-1326. DOI: 10.1111/j.1471-4159.2009.06417.x.

JI Z, FAN Z Q, ZHANG Y, et al . Thiamine deficiency promotes T cell infiltration in experimental autoimmune encephalomyelitis: the involvement of CCL2[J ] . J Immunol, 2014, 193(5): 2157-2167. DOI: 10.4049/jimmunol.1302702.

KJER-NIELSEN L, PATEL O, CORBETT A J, et al . MR1 presents microbial vitamin B metabolites to MAIT cells[J ] . Nature, 2012, 491(7426): 717-723. DOI: 10.1038/nature11605.

LIPSZYC P S, CREMASCHI G A, ZORRILLA-ZUBILETE M, et al . Niacin modulates pro-inflammatory cytokine secretion. a potential mechanism involved in its Anti-atherosclerotic effect[J ] . Open Cardiovasc Med J, 2013, 7: 90-98. DOI: 10.2174/1874192401307010090.

Views

451

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

No data

Related Author

No data

Related Institution

No data

⁰