Changes in choroid plexus volume in healthy adults during natural ageing

Huilin PANG; Zhiming ZHEN; Meng ZENG; Suyi ZHOU; He LIU; Wei CHEN; Wei CHEN

doi:10.16016/j.2097-0927.202405058

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Changes in choroid plexus volume in healthy adults during natural ageing

Clinical Medicine | 更新时间：2026-01-09

- Changes in choroid plexus volume in healthy adults during natural ageing
- Journal of Army Medical University Vol. 46, Issue 22, Pages: 2547-2553(2024)
- 作者机构：
  
  1.400038 重庆，陆军军医大学(第三军医大学)第一附属医院放射科，7T磁共振转化医学中心
  2.510000 广州，西门子数字医疗科技(上海)有限公司广州分公司
- 作者简介：
- 基金信息：
  
  the Natural Science Foundation of Chongqing(cstc2017shms-zdyfX0015)
- DOI：10.16016/j.2097-0927.202405058
  CLC： R322.81;R339.38;R445.2
- Received：16 May 2024，
  
  Revised：2024-07-16，
  
  Published：30 November 2024
- 稿件说明：
移动端阅览
Huilin PANG, Zhiming ZHEN, Meng ZENG, et al. Changes in choroid plexus volume in healthy adults during natural ageing[J]. Journal of Army Medical University, 2024, 46(22): 2547-2553.
DOI：

Huilin PANG, Zhiming ZHEN, Meng ZENG, et al. Changes in choroid plexus volume in healthy adults during natural ageing[J]. Journal of Army Medical University, 2024, 46(22): 2547-2553. DOI： 10.16016/j.2097-0927.202405058.

摘要

目的

研究健康成年人脉络丛(choroid plexus

CP)体积与年龄、性别的相关变化规律以及与其他脑区体积的关联，探讨脉络丛体积(choroid plexus volume，CPV)变化与大脑退行性改变的关系。

方法

2023年8月至2024年2月于陆军军医大学第一附属医院健康体检中心招募320例18~85岁健康受试者，通过简单随机抽样将受试者随机分为2组：7.0T组和3.0T组(每组各160例)，分别进行3.0T和7.0T磁共振成像(magnetic resonance imaging

MRI)的矢状位三维结构MPRAGE序列扫描，使用FreeSurfer 6.0软件获得CP及其他脑区的体积，Spearman相关性分析CPV与年龄的相关性。独立样本

检验分析不同性别之间CPV的差异；偏相关分析CPV与其他脑区体积的相关性。

结果

共纳入311例受试者。3.0T和7.0T MRI扫描结果均显示，CPV与年龄呈正相关(3.0T：

=0.462，

＜0.001；7.0T：

=0.539，

＜0.001)；男性的CPV均显著大于女性[3.0T：(1.40±0.47)

(1.08±0.39)mL，

＜0.001；7.0T：(2.43±0.68)

(1.98±0.38)mL，

＜0.001

]

。此外，3.0T MRI结果显示，CPV与白质高信号、脑脊液的体积呈正相关(

＜0.001)，与全脑灰质、全脑白质、海马、丘脑等体积呈负相关(

＜0.05)。

结论

CPV随年龄的增长而增加，且存在性别差异，不受场强及分辨率限制。CPV与白质高信号、海马等脑区结构具有相关性，提示CPV增大参与大脑退行性改变的过程。CPV变化可作为大脑退行性改变的新影像标志物。

Abstract

Objective

To investigate age- and sex-related changes in choroid plexus (CP) volume in healthy adults

as well as its association with the volumes of other brain regions

and explore the relationship of CP volume changes with degenerative brain alterations.

Methods

A total of 320 healthy subjects aged between 18 and 85 years were prospectively recruited in Physical Examination Center of First Affiliated Hospital to Army Medical University during August 2023 and February 2024. These participants were randomly divided into 7.0T and 3.0T groups

with 160 people in each group. After all of them underwent sagittal three-dimensional structural MPRAGE scans of magnetic resonance imaging (MRI) at 3.0T or 7.0T

FreeSurfer 6.0 segmentation software was employed to obtain the volumes of CP and other brain regions automatically. Spearman analysis was applied to analyze the correlation of CP volume with age. Independent sample

-test analysis was ap

plied to analyze the differences in CP volume between genders. Partial correlation analysis was performed to analyze the correlation between CP volume and the volumes of other brain regions.

Results

A total of 311 subjects were included in the study. The results from both 3.0T and 7.0T MRI showed that CP volume was positively correlated with age (3.0T:

=0.462

0.001; 7.0T:

=0.539

0.001). The males had significantly larger CP volume than the females (3.0T: 1.4±0.47

1.08±0.39 mL

0.001; 7.0T: 2.43±0.68

1.98±0.38 mL

0.001). In addition

3.0T MRI revealed there was a significant positive correlation of CP volume with the volumes of white matter hyperintensities (WMH) and cerebrospinal fluid (

0.001)

as well as a negative correlation with the volumes of gray matter

white matter

hippocampus and thalamus (

0.05).

Conclusion

CP volume is increased with ageing

with gender differences

independent of field strength and resolution. CP volume is correlated with WMH

hippocampus and other brain regions

suggesting that increment in CP volume is involved in age-related degenerative changes in the brain. Changes in CP volume might be regarded as a new imaging marker for the neurodegenerative changes.

关键词

Keywords

references

MACAULAY N, TOFT-BERTELSEN T L. Dual function of the choroid plexus: Cerebrospinal fluid production and control of brain ion homeostasis[J]. Cell Calcium, 2023, 116: 102797. DOI: 10.1016/j.ceca.2023.102797.

QUINTELA T, FURTADO A, DUARTE A C, et al . The role of circadian rhythm in choroid plexus functions[J ] . Prog Neurobiol, 2021, 205: 102129. DOI: 10.1016/j.pneurobio.2021.102129.

REDZIC Z B, PRESTON J E, DUNCAN J A, et al . The choroid plexus-cerebrospinal fluid system: from development to aging[J ] . Curr Top Dev Biol, 2005, 71: 1-52. DOI: 10.1016/S0070-2153(05)71001-2.

SUN A, WANG J. Choroid plexus and drug removal mechanisms[J]. AAPS J, 2021, 23(3): 61. DOI: 10.1208/s12248-021-00587-9.

KLISTORNER S, BARNETT M H, PARRATT J, et al . Choroid plexus volume in multiple sclerosis predicts expansion of chronic lesions and brain atrophy[J ] . Ann Clin Transl Neurol, 2022, 9(10): 1528-1537. DOI: 10.1002/acn3.51644.

LEE J H, OSTALECKI C, OBERSTEIN T, et al . Alzheimer's d isease protease-containing plasma extracellular vesicles transfer to the hippocampus via the choroid plexus[J ] . EBioMedicine, 2022, 77: 103903. DOI: 10.1016/j.ebiom.2022.103903.

MARGONI M, GUEYE M, MEANI A, et al . Choroid plexus enlargement in paediatric multiple sclerosis: clinical relevance and effect of sex[J ] . J Neurol Neurosurg Psychiatry, 2023, 94(3): 181-188. DOI: 10.1136/jnnp-2022-330343.

EGOROVA N, GOTTLIEB E, KHLIF M S, et al . Choroid plexus volume after stroke[J ] . Int J Stroke, 2019, 14(9): 923-930. DOI: 10.1177/1747493019851277.

ALISCH J S R, KIELY M, TRIEBSWETTER C, et al . Characterization of age-related differences in the human choroid plexus volume, microstructural integrity, and blood perfusion using multiparameter magnetic resonance imaging[J ] . Front Aging Neurosci, 2021, 13: 734992. DOI: 10.3389/fnagi.2021.734992.

OLIVEIRA Í A F, ROOS T, DUMOULIN S O, et al . Can 7T MPRAGE match MP2RAGE for gray-white matter contrast?[J ] . Neuroimage, 2021, 240: 118384. DOI: 10.1016/j.neuroimage.2021.118384.

CHOI J D, MOON Y, KIM H J, et al . Choroid plexus volume and permeability at brain MRI within the Alzheimer disease clinical spectrum[J ] . Radiology, 2022, 304(3): 635-645. DOI: 10.1148/radiol.212400.

MODIC M T, WEINSTEIN M A, ROTHNER A D, et al . Calcification of the choroid plexus visualized by computed tomography[J ] . Radiology, 1980, 135(2): 369-372. DOI: 10.1148/radiology.135.2.7367628.

SEROT J M, BÉNÉ M C, FAURE G C. Choroid plexus, aging of the brain, and Alzheimer's disease[J]. Front Biosci, 2003, 8(6): s515-s521. DOI: 10.2741/1085.

SEROT J M,FOLIGUET B, BÉNÉ M C, et al . Choroid plexus and ageing in rats: a morphometric and ultrastructural study[J ] . Eur J Neurosci, 2001, 14(5): 794-798. DOI: 10.1046/j.0953-816x.2001.01693.x.

BUTLER T, WANG X H, CHIANG G C, et al . Choroid plexus calcification correlates with cortical microglial activation in humans: a multimodal PET, CT, MRI study[J ] . AJNR Am J Neuroradiol, 2023, 44(7): 776-782. DOI: 10.3174/ajnr.A7903.

CURRAIS A, FISCHER W, MAHER P, et al . Intraneuronal protein aggregation as a trigger for inflammation and neurodegeneration in the aging brain[J ] . FASEB J, 2017, 31(1): 5-10. DOI: 10.1096/fj.201601184.

MANOUCHEHRI N, STVVE O. Choroid plexus volumetrics and brain inflammation in multiple sclerosis[J]. Proc Natl Acad Sci U S A, 2021, 118(40): e2115221118. DOI: 10.1073/pnas.2115221118.

MINHAS P S, LATIF-HERNANDEZ A, MCREYNOLDS M R, et al . Restoring metabolism of myeloid cells reverses cognitive decline in ageing[J ] . Nature, 2021, 590(7844): 122-128. DOI: 10.1038/s41586-020-03160-0.

BRAVI B, MELLONI E, SERVIDIO L, et al . Choroid plexus volume as a proxy of neuroinflammation in depression[J ] . Eur Psychiatr, 2023, 66(S1): S244-S245. DOI: 10.1192/j.eurpsy.2023.562.

ZENG J X, ZHANG T W, TANG B Q, et al . Choroid plexus volume enlargement in first-episode antipsychotic-naïve schizophrenia[J ] . Schizophrenia, 2024, 10(1): 1. DOI: 10.1038/s41537-023-00424-2.

SANTOS C R, DUARTE A C, QUINTELA T, et al . The choroid plexus as a sex hormone target: Functional implications[J ] . Front Neuroendocrinol, 2017, 44: 103-121. DOI: 10.1016/j.yfrne.2016.12.002.

ISSLER O, NESTLER E J. The molecular basis for sex differences in depression susceptibility[J]. Curr Opin Behav Sci, 2018, 23: 1-6. DOI: 10.1016/j.cobeha.2017.12.019.

MAZURE C M, SWENDSEN J. Sex differences in Alzheimer's disease and other dementias[J]. Lancet Neurol, 2016, 15(5): 451-452. DOI: 10.1016/S1474-4422(16)00067-3.

PICILLO M, NICOLETTI A, FETONI V, et al . The relevance of gender in Parkinson's disease: a review[J ] . J Neurol, 2017, 264(8): 1583-1607. DOI: 10.1007/s00415-016-8384-9.

VOSKUHL R R, PATEL K, PAUL F, et al . Sex differences in brain atrophy in multiple sclerosis[J ] . Biol Sex Differ, 2020, 11(1): 49. DOI: 10.1186/s13293-020-00326-3.

PENG K, KODURI S, XIA F, et al . Impact of sex differences on thrombin-induced hydrocephalus and white matter injury: the role of neutrophils[J ] . Fluids Barriers CNS, 2021, 18(1): 38. DOI: 10.1186/s12987-021-00273-0.

LIZANO P, LUTZ O, LING G, et al . Association of choroid plexus enlargement with cognitive, inflammatory, and structural phenotypes across the psychosis spectrum[J ] . Am J Psychiatry, 2019, 176(7): 564-572. DOI: 10.1176/appi.ajp.2019.18070825.

RIECHER-RÖSSLER A. Sex and gender differences in schizophrenic psychoses[J]. Eur Psychiatry, 2016, 33: S46. DOI: 10.1016/j.eurpsy.2016.01.905.

TAHIRA A, MARQUES F, LISBOA B, et al . Are the 50's, the transition decade, in choroid plexus aging?[J ] . Geroscience, 2021, 43(1): 225-237. DOI: 10.1007/s11357-021-00329-x.

HUANG C C, YANG A C, CHOU K H, et al . Nonlinear pattern of the emergence of white matter hyperintensity in healthy Han Chinese: an adult lifespan study[J ] . Neurobiol Aging, 2018, 67: 99-107. DOI: 10.1016/j.neurobiolaging.2018.03.012.

DAI T J, LOU J W, KONG D Y, et al . Choroid plexus enlargement in amyotrophic lateral sclerosis patients and its correlation with clinical disability and blood-CSF barrier permeability[J ] . Fluids Barriers CNS, 2024, 21(1): 36. DOI: 10.1186/s12987-024-00536-6.

HARSHFIELD E L, SANDS C J, TULADHAR A M, et al . Metabolomic profiling in small vessel disease identifies multiple associations with disease severity[J ] . Brain, 2022, 145(7): 2461-2471. DOI: 10.1093/brain/awac041.

BARIL A A, BEISER A S, MYSLIWIEC V, et al . Slow-wave sleep and MRI markers of brain aging in a community-based sample[J ] . Neurology, 2021, 96(10): e1462-e1469. DOI: 10.1212/WNL.0000000000011377.

ROBALLO K C S, GONÇALVES N J N, PIERI N C G, et al . Regulation of neural stem cells by choroid plexus cells population[J ] . Neurosci Lett, 2016, 626: 35-41. DOI: 10.1016/j.neulet.2016.05.022.

BORLONGAN C V, SKINNER S J, GEANEY M, et al . CNS grafts of rat choroid plexus protect against cerebral ischemia in adult rats[J ] . Neuroreport, 2004, 15(10): 1543-1547. DOI: 10.1097/01.wnr.0000133298.84901.cf.

STOPA E G, BERZIN T M, KIM S, et al . Human choroid plexus growth factors: What are the implications for CSF dynamics in Alzheimer's disease?[J ] . Exp Neurol, 2001, 167(1): 40-47. DOI: 10.1006/exnr.2000.7545.

BARUCH K, DECZKOWSKA A, SCHWARTZ M. Age-associated immunological dysfunction of the brain's choroid plexus negatively affects cognition and hippocampal neurogenesis[J]. Brain Behav Immun, 2015, 49: e5. DOI: 10.1016/j.bbi.2015.06.039.

ARNAUD K, OLIVEIRA MOREIRA V, VINCENT J, et al . Choroid plexus APP regulates adult brain proliferation and animal behavior[J ] . Life Sci Alliance, 2021, 4(11): e202000703. DOI: 10.26508/lsa.202000703.

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