Application of cypropofol and propofol combined with low-dose alfentanil in gastroenteroscopy

Yu WANG; Yufang LENG; Dongbin LI; Yang XING; Liya CHANG; Zicen ZHAO

doi:10.16016/j.2097-0927.202404123

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Application of cypropofol and propofol combined with low-dose alfentanil in gastroenteroscopy

Clinical Medicine | 更新时间：2026-01-09

- Application of cypropofol and propofol combined with low-dose alfentanil in gastroenteroscopy
- Journal of Army Medical University Vol. 46, Issue 23, Pages: 2642-2648(2024)
- 作者机构：
  
  1.730000 兰州，兰州大学第一临床医学院
  2.730000 兰州，兰州大学第一医院麻醉手术科
- 作者简介：
- 基金信息：
  
  the Project of Medical Education Innovation and Development Program of Lanzhou University(lzuyxcx-2022-108)
- DOI：10.16016/j.2097-0927.202404123
  CLC： R573;R614.2;R971.2
- Received：26 April 2024，
  
  Revised：2024-08-01，
  
  Published：15 December 2024
- 稿件说明：
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Yu WANG, Yufang LENG, Dongbin LI, et al. Application of cypropofol and propofol combined with low-dose alfentanil in gastroenteroscopy[J]. Journal of Army Medical University, 2024, 46(23): 2642-2648.
DOI：

Yu WANG, Yufang LENG, Dongbin LI, et al. Application of cypropofol and propofol combined with low-dose alfentanil in gastroenteroscopy[J]. Journal of Army Medical University, 2024, 46(23): 2642-2648. DOI： 10.16016/j.2097-0927.202404123.

摘要

目的

研究环泊酚与丙泊酚分别复合小剂量阿芬太尼用于胃肠镜检查麻醉效果和不良反应。

方法

选择2024年1-2月于兰州大学第一医院消化内镜中心择期行胃肠镜检查的患者162例，男86例，女76例，年龄18~65岁，BMI 18~30 kg/m

ASA≤Ⅱ级。将患者随机分为2组，每组81例：丙泊酚组(P组)和环泊酚组(C组)。所有患者静注阿芬太尼7 μg/kg，30 s后P组静注丙泊酚2 mg/kg、C组静注环泊酚0.4 mg/kg；待患者改良警觉/镇静评分(modified observer’s assessment of alertness/sedation，MOAA/S)≤1分，开始胃镜进镜操作。记录检查时间、镇静成功例数、诱导时间、苏醒时间。记录患者心率、血压、脉搏血氧饱度。记录低血

压、呼吸抑制、注射痛、术中体动、恶心呕吐等不良反应发生情况，及内镜医师和患者对麻醉的满意度。

结果

2组患者镇静成功率、诱导时间、苏醒时间差异均无统计学意义。与P组比较，C组患者术中生命体征更平稳，C组注射痛、呼吸抑制、低血压发生率均明显降低(

＜0.05)，患者对麻醉的满意度明显增高(

＜0.05)，2组内镜医师对麻醉的满意度差异无统计学意义。

结论

复合小剂量阿芬太尼，环泊酚0.4 mg/kg在胃肠镜诊疗中能提供与丙泊酚2 mg/kg相似的镇静效果，诱导和苏醒时间相当；患者术中生命体征更平稳，低血压、呼吸抑制、注射痛等不良反应少，患者满意度高，值得临床推广。

Abstract

Objective

To investigate the anesthetic effects and adverse effects of cypropofol and propofol combined with alfentanil

respectively

for gastroenteroscopy.

Methods

A total of 162 patients who underwent elective gastroenteroscopy at the Gastrointestinal Endoscopy Center of the First Hospital of Lanzhou University from January to February 2024 were enrolled

including 86 males and 76 females

at an age of 18~65 years old

with a BMI value of 18~30 kg/m

and ASA grade ≤Ⅱ. They were randomly divided into propofol group (Group P) and cypropofol group (Group C)

with 81 cases in each group. All patients were sedated with 0.7 μg/kg alfentanil

and in 30 s later

2 mg/kg propofol and 0.4 mg/kg cypropofol was intravenously dripped into Group P and Group C

respectively. When the modified alertness/sedation score (MOAA/S) ≤1

a gastroscope was started to insert. The related indicators

including total procedure time

successful cases of sedation

induction time and awakening time

heart rate

blood pressure

and pulse oximetry saturation were recorded

occurrence of adverse reactions such as hypotension

respiratory depression

injection pain

intraoperative body movement

nausea and vomiting were observed

and the satisfaction of endoscopists and of patients to anesthesia were recorded and compared between the 2 groups.

Results

There were no statistical differences in the success rate of sedation

induction time and awakening time between the 2 groups. The patien

ts of the Group C had more stable intraoperative vital signs

statistically lower incidences of injection pain

respiratory depression and hypotension (

0.05)

and increased satisfaction for anesthesia (

0.05) when compared with those in Group P. No obvious difference were observed in the satisfaction of endoscopist to anesthesia between the 2 groups.

Conclusion

In combination with small-dose alfentanil

0.4 mg/kg cypropofol shows similar sedation effect as 2 mg/kg propofol in gastroenteroscopy

with comparable induction and awakening time. Cypropofol has more advantages in stable intraoperative vital signs

less adverse effects such as low blood pressure

respiratory depression and injection pain

higher the patient satisfaction

which is worthy of clinical promotion.

关键词

Keywords

references

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