IVIM-DWI-based radiomic model for preoperative prediction of hepatocellular carcinoma differentiation

Yuxiang ZHUANG; Xiaofeng LI; Daiquan ZHOU; Lianqin KUANG; Min YAN

doi:10.16016/j.2097-0927.202403098

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IVIM-DWI-based radiomic model for preoperative prediction of hepatocellular carcinoma differentiation

Clinical Medicine | 更新时间：2026-01-09

- IVIM-DWI-based radiomic model for preoperative prediction of hepatocellular carcinoma differentiation
- Journal of Army Medical University Vol. 46, Issue 20, Pages: 2322-2329(2024)
- 作者机构：
  
  401120 重庆，重庆医科大学附属第三医院放射科
- 作者简介：
- 基金信息：
  
  the Project of Science and Technology Research of Chongqing Education Commission(KJQN202300452);the Construction Project for Clinical Key Specialties of Chongqing(SLCZDZK202202)
- DOI：10.16016/j.2097-0927.202403098
  CLC： R445.2;R730.21;R735.7
- Received：25 March 2024，
  
  Revised：2024-06-02，
  
  Published：30 October 2024
- 稿件说明：
移动端阅览
Yuxiang ZHUANG, Xiaofeng LI, Daiquan ZHOU, et al. IVIM-DWI-based radiomic model for preoperative prediction of hepatocellular carcinoma differentiation[J]. Journal of Army Medical University, 2024, 46(20): 2322-2329.
DOI：

Yuxiang ZHUANG, Xiaofeng LI, Daiquan ZHOU, et al. IVIM-DWI-based radiomic model for preoperative prediction of hepatocellular carcinoma differentiation[J]. Journal of Army Medical University, 2024, 46(20): 2322-2329. DOI： 10.16016/j.2097-0927.202403098.

摘要

目的

基于体素内不相干运动扩散加权成像(intravoxel incoherent motion diffusion-weighted imaging

IVIM-DWI)功能图像构建影像组学相关模型，探讨其术前预测肝细胞癌(hepatocellular carcinoma

HCC)分化程度的价值。

方法

纳入2018年6月至2024年1月于重庆医科大学附属第三医院接受手术治疗的187例HCC患者的临床及影像学资料，根据术后病理结果分为低分化组(

=58)和非低分化组(

=129)，以8 ∶2的比例随机分为训练组149例和验证组38例。采用单因素分析评估与HCC分化程度相关的临床资料并构建临床模型；应用Pyradiomics软件提取IVIM-DWI功能图像的组学特征，采用最小绝对收缩和选择算子逻辑回归算法筛选出与HCC分化程度高度相关的影像组学特征，分别运用支持向量机(support vector machine

SVM)、逻辑回归(logistic regression

LR)、随机森林(random forest

RF)算法构建不同的影像组学模型；采用SVM算法构建影像组学-临床联合模型。采用10折交叉验证进行模型内部验证；运用受试者工作特征曲线(receiver operating characteristic curve

ROC)、曲线下面积(area under the curve

AUC)、校准曲线、决策曲线分析(decision curve analysis

DCA)评价临床模型、影像组学模型、影像组学-临床联合模型的诊断价值和临床收益。

结果

共提取4 060个影像组学特征，经过特征筛选及降维后，最终纳入24个特征进行模型构建。结果显示，影像组学模型、影像组学-临床联合模型的预测性能优于临床模型。运用SVM算法构建的影像组学模型、影像组学-临床联合模型间进行比较，在训练集中影像组学模型AUC=0.954(0.908~1.000)，影像组学-临床联合模型AUC=0.943(0.905~0.982)，二者间差异无统计学意义；在验证集中影像组学模型AUC=0.807(0.640~0.975)，影像组学-临床联合模型AUC=0.876(0.743~1.000)，二者间差异具有统计学意义(

＜0.05)。校准曲线显示影像组学模型和影像组学-临床联合模型具有良好的拟合优度。DCA曲线显示影像组学模型和影像组学-临床联合模型的净收益较高，阈概率范围较大，影像组学-临床联合模型的临床净收益最大(

＜0.05)。

结论

基于IVIM-DWI功能图像构建的影像组学模型和影像组学-临床联合模型能够在术前较准确地预测HCC分化程度。

Abstract

Objective

To construct a radiomic model based on intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) for preoperative prediction of hepatocellular carcinoma (HCC) differentiation and validate its clinical value.

Methods

Clinical and imaging data of 187 HCC patients who received surgical treatment in the Third Affiliated Hospital of Chongqing Medical University from June 2018 to January 2024 were collected and retrospectively analyzed. According to the postoperative pathological results

they were divided into low-differentiation group (

=58) and non-low-differentiation group (

=129)

and randomly divided into the training group (

=149) and the validation group (

=38) with the ratio of 8 ∶2. Univariate analysis was used to assess the clinical indicators related to HCC differentiation

and then a clinical model was constructed. Pyramidimics software was used to extract the radiomic features of IVIM-DWI functional images

and minimum absolute contraction and selection operator logistic regression algorithm were employed to screen those highly correlated indicators with HCC differentiation. Support vector machine (SVM)

logistic regression (LR) and random forest (RF) algorithms were utilized to construct different image omics models. SVM algorithm was applied to construct the combined imaging omics and clinical model. The internal verification of the model was carried out by using ten-fold cross-validation. Receiver operating characteristic (ROC) curve

area under the curve (AUC)

calibration curve

and decision curve analysis (DCA) were used to evaluate the diagnostic value and clinical benefits of clinical model

radiomic model

and their combination.

Results

A total of 4 060 radiological features were extracted

and after feature screening and dimensionality reduction

24 features were finally included to construct the model. Among all models

the pre

dictive performance of the radiomic model and the radiomic-clinical combined model was better than that of the clinical model. In the comparison between the radiomic model constructed by SVM algorithm and the radiomics-clinical combined model

the AUC value was 0.954 (0.908~1.000) for the former model

and was 0.943 (0.905~0.982) for the latter model in the training set

and there was no significant difference between them. In the validation set

the AUC value was 0.807 (0.640~0.975) and 0.876 (0.743~1.000)

respectively

with statistical difference between the 2 models (

0.05). Calibration curve analysis showed that the radiomic model and the radiomics-clinical combined model had good goodness of fit. DCA indicated that the net benefit was higher and the threshold probability range was larger in both the radiomic model and the radiomics-clinical combined model

and the net benefit of the combined model was larger.

Conclusion

Both the radiomic model and the combined radiomics-clinical model constructed on the basis of IVIM-DWI functional images can better predict the severity of HCC differentiation before surgery.

关键词

Keywords

references

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