Causality between ischemic stroke and epilepsy based on Mendelian randomization

Yun SHU; Qing YUAN; Zhifeng WU; Chunqing ZHANG

doi:10.16016/j.2097-0927.202403006

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Causality between ischemic stroke and epilepsy based on Mendelian randomization

Neuroscience | 更新时间：2026-01-09

- Causality between ischemic stroke and epilepsy based on Mendelian randomization
- Journal of Army Medical University Vol. 46, Issue 20, Pages: 2276-2283(2024)
- 作者机构：
  
  1.510006 广州，广州中医药大学针灸康复临床医学院
  2.400037 重庆，陆军军医大学(第三军医大学)第二附属医院儿科
  3.400037 重庆，陆军军医大学(第三军医大学)第二附属医院神经外科全军癫痫诊治中心
- 作者简介：
- 基金信息：
  
  the General Program of National Natural Science Foundation of China(82171463);the Joint Medical Research Project for Young and Middle-Aged Top Talents of Chongqing Science and Technology Commission and Chongqing Health Commission(2024GDRC013)
- DOI：10.16016/j.2097-0927.202403006
  CLC： R192.6;R195.1;R473.1
- Received：03 March 2024，
  
  Revised：2024-05-19，
  
  Published：30 October 2024
- 稿件说明：
移动端阅览
Yun SHU, Qing YUAN, Zhifeng WU, et al. Causality between ischemic stroke and epilepsy based on Mendelian randomization[J]. Journal of Army Medical University, 2024, 46(20): 2276-2283.
DOI：

Yun SHU, Qing YUAN, Zhifeng WU, et al. Causality between ischemic stroke and epilepsy based on Mendelian randomization[J]. Journal of Army Medical University, 2024, 46(20): 2276-2283. DOI： 10.16016/j.2097-0927.202403006.

摘要

目的

探索缺血性脑卒中与不同类型癫痫之间的因果关系，为缺血性脑卒中与癫痫的发病风险提供遗传学证据支持。

方法

基于全基因组关联分析的汇总数据，采用MR-Egger回归、加权中位数法、逆方差加权法进行孟德尔随机化(Mendelian randomization

MR)分析，使用MR-Egger回归检验、MR-PRESSO检验和留一法进行敏感性分析。

结果

两样本MR分析表明缺血性脑卒中与癫痫(

=1.10，

=0.036)和全面性癫痫(

=1.25，

=0.001)的风险表现出因果关系，但与局灶性癫痫(

=1.06，

=0.360)之间未显现因果关系。另外，舒张压(

=1.12，

=0.002)和BMI(

=1.08，

=0.015)也与癫痫呈现因果关系，进一步使用多变量MR分析方法，校正混杂因素影响之后，只有缺血性脑卒中(

=1.18，

=3.770×10

-6

)和癫痫风险之间呈现因果关系。

结论

缺血性脑卒中和全面性癫痫风险之间存在因果关联，可据此进行卒中后癫痫的风险分层。

Abstract

Objective

To explore the causal relationship between ischemic stroke and different types of epilepsy so as to provide genetic evidence for the risk of epilepsy after ischemic stroke.

Methods

Based on the summary data of genome-wide association study

Mendelian randomization (MR) analysis was performed with MR-Egger regression

weighted median and inverse-variance weighting. Sensitivity analysis was conducted by using MR-Egger regression test

MR-PRESSO test and leave-one-out method.

Results

Two-sample MR analysis showed that there was a causal relationship between ischemic stroke and the risk of epilepsy (

=1.10

=0.036) and generalized epilepsy (

=1.25

=0.001)

but no such relationship was observed with the risk of focal epilepsy (

=1.06

=0.360). In addition

diastolic blood pressure (

=1.12

=0.002) and BMI (

=1.08

=0.015) also had a causal relationship with the risk of epilepsy. After adjusting confounding factors

multivariate MR analysis revealed that only ischemic stroke (

=1.18

=3.770×10

-6

) and epilepsy risk had a causal relationship.

Conclusion

There is a causal relationship between ischemic stroke and the risk of generalized epilepsy

which can be used to stratify the risk of post-stroke epilepsy.

关键词

Keywords

references

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