Successful treatment of infantile hepatic hemangioma with high-output heart failure: report of 3 cases and literature review

Jian YANG; Xiaoke DAI; Mingman ZHANG; Qiang XIONG

doi:10.16016/j.2097-0927.202402061

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Successful treatment of infantile hepatic hemangioma with high-output heart failure: report of 3 cases and literature review

Clinical Medicine | 更新时间：2026-01-09

- Successful treatment of infantile hepatic hemangioma with high-output heart failure: report of 3 cases and literature review
- Journal of Army Medical University Vol. 46, Issue 22, Pages: 2569-2575(2024)
- 作者机构：
  
  1.402160 重庆，重庆市永川区妇幼保健院儿外科
  2.400014 重庆，重庆医科大学附属儿童医院肝胆外科，国家儿童健康与疾病临床医学研究中心，国家儿童健康与疾病临床医学研究中心，儿童发育疾病研究教育部重点实验室，儿童代谢与炎症性疾病重庆市重点实验室
- 作者简介：
- 基金信息：
  
  the Construction Project for National Clinical Key Specialties(国卫办医政函[2024]189号)
- DOI：10.16016/j.2097-0927.202402061
  CLC： R725.416;R726.573;R732.2
- Received：22 February 2024，
  
  Revised：2024-06-28，
  
  Published：30 November 2024
- 稿件说明：
移动端阅览
Jian YANG, Xiaoke DAI, Mingman ZHANG, et al. Successful treatment of infantile hepatic hemangioma with high-output heart failure: report of 3 cases and literature review[J]. Journal of Army Medical University, 2024, 46(22): 2569-2575.
DOI：

Jian YANG, Xiaoke DAI, Mingman ZHANG, et al. Successful treatment of infantile hepatic hemangioma with high-output heart failure: report of 3 cases and literature review[J]. Journal of Army Medical University, 2024, 46(22): 2569-2575. DOI： 10.16016/j.2097-0927.202402061.

摘要

目的

总结婴儿肝血管瘤(infantile hepatic hemangioma

IHH)伴高输出量心力衰竭的临床特点、治疗方案以及治疗效果。

方法

收集2020年10月至2023年10月在重庆医科大学附属儿童医院肝胆外科收治的3例婴儿肝血管瘤伴高输出量心力衰竭病例，并分析其病例特点、治疗方案和治疗效果。同时，通过中国知网、万方数据库和中华医学期刊全文数据库及PubMed数据库检索国内外报道的病例并进行分析总结。

结果

3例患儿中，男性1例，女性2例，年龄分别为1 d、19 d和80 d，主要临床症状为呼吸急促和呼吸困难。所有患儿入院后迅速进展为呼吸衰竭、肺动脉高压和心力衰竭。诊断弥漫性IHH 2例，局灶性IHH 1例，其中1例弥漫性IHH接受了经皮肝动脉栓塞术的介入治疗，手术当天心肺功能恢复，并脱离呼吸机。另外2例患儿在使用普萘洛尔联合激素药物治疗后，估算右室收缩压和二尖瓣流量比在心脏彩超监测中最为敏感。文献复习共纳入24例患儿，其中4例治疗失败死亡，3例缓解，17例完全恢复。

结论

普萘洛尔联合激素药物治疗以及经皮肝动脉栓塞术是治疗IHH伴高输出量心力衰竭的有效方法。通过估算右室收缩压和二尖瓣流量比进行血流动力学监测，可能是潜在的评估药物治疗效果的早期敏感指标。

Abstract

Objective

To summarize the clinical characteristics

treatment regimen and clinical outcomes of infantile hepatic hemangioma (IHH) with high-output heart failure (HHF).

Methods

A retrospective analysis was conducted on 3 IHH infants with concomitant HHF admitted to the Children's Hospital of Chongqing Medical University during October 2020 and October 2023. The characteristics

treatment plans and efficacy were analyzed in the 3 cases. CNKI

WANFANG DATA

Chinese Medical Association Journal Full-text Database

and PubMed databases were retrieved to search domestic and foreign literature concerning the diseases

and the enrolled cases were analyzed and reviewed.

Results

Among the 3 infants

they were 1 male and 2 females

and aged 1 d

19 d and 80 d

respectively. The main clinical symptoms were dyspnea and respiratory distress. All 3 patients rapidly progressed to respiratory failure

pulmonary hypertension and heart failure after admission. Diffuse IHH was diagnosed in 2 cases and focal IHH in 1 case. One case of diffuse IHH underwent percutaneous hepatic artery embolization

and the cardiopulmonary function recovered on the day of surgery

and the ventilator was removed. In the other 2 cases

propranolol combined with steroid medication was used

and the estimated right ventricular systolic pressure and E wave to A wave mitral flow ratio (E/A) were the most sensitive indicators in echocardiographic monitoring. There were 24 cases included in literature review

with 4 cases of treatment failure and death

3 cases of remission

and 17 cases of complete recovery.

Conclusion

Propranolol combined with steroid medication and percutaneous hepatic artery embolization are effective in treating IHH complicated with HHF. Right ventricular systolic pressure and E/A during drug therapy might be early sensitive marker for the early evaluation of potential therapeutic effects of drugs.

关键词

Keywords

references

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