Platelet/hemoglobin ratio predicts severity of diabetic foot ulcer: a report of 345 cases

Shuangjiang LI; Shizhu BIAN; Hongqian WANG; Hengxin LI; Guiliang PENG; Li GUO

doi:10.16016/j.2097-0927.202312077

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Platelet/hemoglobin ratio predicts severity of diabetic foot ulcer: a report of 345 cases

Clinical Medicine | 更新时间：2026-01-09

- Platelet/hemoglobin ratio predicts severity of diabetic foot ulcer: a report of 345 cases
- Journal of Army Medical University Vol. 46, Issue 9, Pages: 1057-封3(2024)
- 作者机构：
  
  1.400038 重庆，陆军军医大学(第三军医大学)：第一附属医院内分泌科
  2.400038 重庆，陆军军医大学(第三军医大学)：基础医学院
  3.400037 重庆，陆军军医大学(第三军医大学)第二附属医院心血管内科，全军心血管病研究所
  4.400038 重庆，陆军军医大学(第三军医大学)：第一附属医院医学大数据与人工智能中心
  5.400038 重庆，陆军军医大学(第三军医大学)：第一附属医院学员管理中心
- 作者简介：
- 基金信息：
  
  the General Program of Natural Science Foundation of Chongqing(cstc2019jcyj-msxmX0576)
- DOI：10.16016/j.2097-0927.202312077
  CLC： R181.32;R446.113;R587.2
- Received：14 December 2023，
  
  Revised：2024-01-31，
  
  Published：15 May 2024
- 稿件说明：
移动端阅览
Shuangjiang LI, Shizhu BIAN, Hongqian WANG, et al. Platelet/hemoglobin ratio predicts severity of diabetic foot ulcer: a report of 345 cases[J]. Journal of Army Medical University, 2024, 46(9): 1057-封3.
DOI：

Shuangjiang LI, Shizhu BIAN, Hongqian WANG, et al. Platelet/hemoglobin ratio predicts severity of diabetic foot ulcer: a report of 345 cases[J]. Journal of Army Medical University, 2024, 46(9): 1057-封3. DOI： 10.16016/j.2097-0927.202312077.

摘要

目的

探讨血小板/血红蛋白比值(platelet/hemoglobin

PHR)与糖尿病足溃疡(diabetic foot ulcer

DFU)严重程度的关系及其对DFU进展的预测价值。

方法

纳入陆军军医大学第一附属医院内分泌科2018年3月至2023年3月住院的

345名DFU患者，收集患者的一般人口学资料

采血样本送本院检验科检测糖化血红蛋白(HbA1c)、空腹血糖(FPG)、血生化、血常规相关指标，并依据公式计算PHR。根据Wanger分级分为轻度溃疡组(

=145)和重度溃疡组(

=200)。比较2组患者基线资料的差异；多因素Logistic回归分析确定DFU重度溃疡的独立预测因子；绘制受试者工作特性曲线，以评估PHR预测DFU进展的价值。

结果

重度溃疡组患者的HbA1c、FPG、血小板计数(PLT)和PHR等均显著高于轻度溃疡组(

0.05)。多因素Logistic回归发现PHR、男性比例是DFU患者进展为重度溃疡的独立危险因素(

0.05)，而HDL-C是其保护因素(

0.05)。PHR预测DFU患者发生重度溃疡的曲线下面积为0.701(95%

：0.646~0.756)。

结论

PHR与DFU的严重程度密切相关，且PHR对重度糖尿病足溃疡具有一定的预测价值。

Abstract

Objective

To investigate the relationship between platelet/hemoglobin ratio (PHR) and the severity of diabetic foot ulcer (DFU) and its predictive value for DFU progression.

Methods

A retrospective study was performed in 345 DFU patients treated in Department of Endocrinology

the First Affiliated Hospital of Army Medical University from March 2018 to March 2023. Their general demographic information was obtained

and the results of laboratory tests

including hemoglobin A1c (HbA1c)

fasting plasma glucose (FPG)

biochemical and related blood routine indicators were collected. According to Wanger grading

the patients were assigned into mild (

=145) and severe ulcer groups (

=200). The demographic data and clinical parameters were compared between the 2 groups. Multivariate logistic regression model was applied to identify the independent predictors for severe ulcer in DFU

and receiver operating characteristic (ROC) curve was plotted to evaluate the predictive performance of PHR for DFU progression.

Results

The severe ulcer group presented remarkable increases in male proportion

HbA1c and FPG levels

platelet (PLT)count and PHR when compared with the mild ulcer group (

0.05). Multivariate logistic regression analysis

revealed that PHR and male were independent risk factors

while

HDL-C was a protective factor for progression to severe ulcer in DFU patients (

0.05). ROC curve analysis showed that the area under the curve of PHR for predicting severe ulcer was 0.701 (95%

: 0.646~0.756).

Conclusion

PHR is strongly associated with the severity of DFU

and shows certain predictive value for the progression to severe ulcer in DFU patients.

关键词

Keywords

references

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