Impact of positive preoperative <italic style="font-style: italic">E. coli</italic> infection on surgical site infection and postoperative fever after urethral strictoplasty

Hao PAN; Yu LIU; Xi JIN; Hong LI; Kunjie WANG

doi:10.16016/j.2097-0927.202311096

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Impact of positive preoperative E. coli infection on surgical site infection and postoperative fever after urethral strictoplasty

Clinical Medicine | 更新时间：2026-01-09

- Impact of positive preoperative E. coli infection on surgical site infection and postoperative fever after urethral strictoplasty
- Journal of Army Medical University Vol. 46, Issue 3, Pages: 277-282(2024)
- 作者机构：
  
  610041 成都，四川大学华西医院泌尿外科
- 作者简介：
- 基金信息：
- DOI：10.16016/j.2097-0927.202311096
  CLC： R181.32;R378.21;R693.2
- Received：20 November 2023，
  
  Revised：2023-12-12，
  
  Published：15 February 2024
- 稿件说明：
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Hao PAN, Yu LIU, Xi JIN, et al. Impact of positive preoperative E. coli infection on surgical site infection and postoperative fever after urethral strictoplasty[J]. Journal of Army Medical University, 2024, 46(3): 277-282.
DOI：

Hao PAN, Yu LIU, Xi JIN, et al. Impact of positive preoperative E. coli infection on surgical site infection and postoperative fever after urethral strictoplasty[J]. Journal of Army Medical University, 2024, 46(3): 277-282. DOI： 10.16016/j.2097-0927.202311096.

摘要

目的

探究大肠杆菌相较其他病原体感染，是否增加尿道成形术后的手术部位感染以及术后发热。

方法

采用回顾性队列研究的方式，纳入华西医院泌尿外科2011-2019年接受尿道狭窄段切除和端端吻合术来治疗尿道球部或后尿道狭窄的患者共506例，按术后是否发生手术部位感染(surgical site infection

SSI)和术后发热(postoperative fever

POF)分别分为SSI组(19例)和非SSI组(487例)，POF组(61例)和非POF组(445例)；采用多元Logistic回归分析与LASSO算法筛选潜在的危险因素；按照术前尿培养结果将患者分为大肠杆菌感染组(80例)和其他病原体感染组(222例)，通过倾向评分匹配减少潜在偏倚后(匹配后大肠杆菌组：48例；其他病原体组：192例)，比较大肠杆菌感染组与其他病原体感染组在手术部位感染和术后发热方面的差异。

结果

在多元Logistic回归分析与LASSO算法中，术前尿培养阳性是预测手术部位感染(

=0.012)和术后发热(

＜0.01)的独立危险因素，在302例术前尿培养阳性的患者中，大肠杆菌感染比例位居第一(26.5%)。倾向评分匹配处理后，大肠杆菌组与其他病原体组的手术部位感染的比例分别为29.2%和2.1%(

＜0.01)。与其他病原体感染组相比，大肠杆菌感染组的术后发热比例也较高(27.1%

13.5%

=0.02)。

结论

与其他病原体感染相比，术前大肠杆菌感染会增加尿道成形术后的手术部位感染、术后发热风险。

Abstract

Objective

To investigate whether

E. coli

infection increases surgical site infection and postoperative fever in comparison

with other pathogens.

Methods

A retrospective cohort study was conducted on 506 patients who underwent urethral segment resection and end anastomosis for the bulb or posterior urethral stenosis in our department during 2011 and 2019. According to occurrence of postoperative surgical site infection (SSI) or postoperative fever (POF)

they were divided into SSI group (

=19) and non-SSI group (

=487)

as well as POF group (

=61) and non-POF group (

=445 patients) respectively. Multivariate logistic regression analysis and LASSO algorithm were used to screen the potential risk factors. According to the results of positive preoperative urine culture in 302 patients

they were subsequently divided into

E. coli

infection group (

=80) and other pathogen infection group (

=222)

and after reducing potential bias with propensity score matching

finally 48 patients were assigned into

E. coli

infection group

and 192 into other pathogen infection groups. The differences in occurrences of SSI and POF were compared between the above 2 groups of patients.

Results

Multivariate logistic regression analysis and LASSO algorithm revealed that positive preoperative urine culture was an independent risk factor for predicting SSI (

=0.012) and POF (

0.01). Among the 302 patients with positive results in preoperative urine culture

E. coli

infections was in the first rank

accounting for 26.5%. After propensity score matched treatment

the incidence of SSI in the

E. coli

group and other pathogen groups was 29.2% and 2.1%

respectively (

0.01). The incidence of POF was also higher in the

E. coli

infection group than the other pathogen infection group (27.1%

13.5%

=0.02).

Conclusion

Preoperative

E. coli

infection may increase the risk of SSI and POF after urethroplasty when compared with other pathogen infections.

关键词

Keywords

references

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⁰

Impact of positive preoperative E. coli infection on surgical site infection and postoperative fever after urethral strictoplasty

DOI：10.16016/j.2097-0927.202311096

摘要

Abstract

关键词

Keywords

references