Correlation between development of terminal rectal ganglion and spinal cord/sacral abnormalities in boys with complex anorectal malformations

Minming CHEN; Jinping HOU; Wei FENG; Xiaohong DIE; Chenzhu XIANG; Yi WANG

doi:10.16016/j.2097-0927.202311063

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Correlation between development of terminal rectal ganglion and spinal cord/sacral abnormalities in boys with complex anorectal malformations

Clinical Medicine | 更新时间：2026-01-09

- Correlation between development of terminal rectal ganglion and spinal cord/sacral abnormalities in boys with complex anorectal malformations
- Journal of Army Medical University Vol. 46, Issue 3, Pages: 265-270(2024)
- 作者机构：
  
  400015 重庆，重庆医科大学附属儿童医院普外新生儿外科，国家儿童健康与疾病临床医学研究中心，儿童发育疾病研究教育部重点实验室，儿科学重庆市重点实验室
- 作者简介：
- 基金信息：
  
  the General Project of Clinical Medical Research of National Clinical Research Center for Children’s Health and Disease(NCRCCHD-2022-GP-03);the Supporting Program for Youth Innovation Group in Future Medicine of Chongqing Medical University （W0125）(W0125)
- DOI：10.16016/j.2097-0927.202311063
  CLC： R181.32;R682.3;R726.571
- Received：13 November 2023，
  
  Revised：2023-12-13，
  
  Published：15 February 2024
- 稿件说明：
移动端阅览
Minming CHEN, Jinping HOU, Wei FENG, et al. Correlation between development of terminal rectal ganglion and spinal cord/sacral abnormalities in boys with complex anorectal malformations[J]. Journal of Army Medical University, 2024, 46(3): 265-270.
DOI：

Minming CHEN, Jinping HOU, Wei FENG, et al. Correlation between development of terminal rectal ganglion and spinal cord/sacral abnormalities in boys with complex anorectal malformations[J]. Journal of Army Medical University, 2024, 46(3): 265-270. DOI： 10.16016/j.2097-0927.202311063.

摘要

目的

探讨男性复杂肛门直肠畸形(anorectal malformations

ARMs)患儿直肠末端神经发育情况与患者脊髓/骶骨异常的关系，以期提高对ARMs中肠神经发育异常的相关认识。

方法

回顾性收集我院2015-2021年收治符合纳排标准的男性复杂ARMs患儿的临床资料，在肛门成形术时取患者末端直肠标本，采用苏木精-伊红染色后显微镜下观察神经节发育情况并进行分组(G1组：有神经节细胞；G2组：无神经节细胞)。利用影像学技术评估患者脊髓及骶骨是否存在异常，并将其与直肠末端肠神经节发育情况进行相关性分析。

结果

本研究共纳入患者139例，行肛门成形术时中位年龄为5.77(4.57

6.97)个月。G1组(80例，57.6%)与G2组(59例，42.4%)在ARMs病理类型、手术年龄的差异无统计学意义。经影像学证实出现脊髓

异常(SCA)48例(34.5%)，骶骨发育异常25例(18.0%)，尾骨发育异常18例(12.9%)。G1组与G2组脊髓发育不良及骶骨发育异常发生率的差异具有统计学意义(

＜0.05)；在脊髓发育不良中，终丝脂肪变性、脊髓空洞的差异具有统计学意义(

＜0.05)。G1组、G2组正位及侧位SR值分别为(0.72±0.10

0.67±0.12)、(0.77±0.09

0.72±0.09)，差异有统计学意义(

＜0.05)。将相关因素纳入多因素Logistic回归分析，结果显示骶骨发育异常、终丝脂肪变、脊髓空洞为男性复杂ARMs患儿直肠末端神经节缺失的独立预测因素。

结论

男性复杂性ARMs直肠末端神经节发育情况与脊髓及骶骨发育异常密切相关。骶骨发育异常、终丝脂肪变、脊髓空洞为男性复杂ARMs患儿直肠末端神经节缺失的独立预测因素。

Abstract

Objective

To investigate the relationship between the development of terminal rectal ganglion and spinal cord/sacral abnormalities in boys with complex anorectal malformations (ARMs) in order to improve the understanding of rectal ganglion development abnormalities in ARMs patients.

Methods

A retrospective trial was conducted on the male patients with complex ARMs admitted to our hospital from 2015 to 2021. The terminal rectal specimens were taken from them during anoplasty. According to the findings on development of terminal rectal ganglion after HE staining

the patients were classified into G1 group (ganglion cells observed) and G2 group (no ganglion cells observed). Imaging techniques were used to evaluate whether there were abnormalities in the spinal cord and sacrum

and their correlation with the terminal rectal ganglion development was analyzed.

Results

A total of 139 patients were enrolled

and their median age at anoplasty was 5.77(4.57

6.97) months. There were no significant differences between the G1 (

=80

57.6%) and G2 (

=59

42.4%) groups in ARMs pathological type (

=0.706) and age at surgery (

=0.140). Radiological findings showed there were 48 cases (34.5%) of spinal cord anomalies (SCA)

25 cases (18.0%) of sacral abnormalities and 18 cases (12.9%) of coccyx abnormalities. No si

gnificant differences were observed in the incidences of SCA and sacral abnormalities between the G1 and G2 groups (

0.05). Moreover

the differences of fatty filum terminale and syrinx were statistically significant (

0.05). In addition

the ratio of sacrum to coccyx between the G1 and G2 groups were 0.72±0.10

0.67±0.12 (

0.05) of the anteroposterior position and 0.77±0.09

0.72±0.09 (

0.05) of the lateral position. Multivariate logistic regression analysis showed that sacral abnormalities

fatty filum terminale and syrinx were independent predictors of rectal terminal ganglion absence in male patients with complex ARMs.

Conclusion

The development of terminal rectal ganglia in male patients with ARMs is closely associated with the abnormalities of spinal cord and sacrum. Sacral abnormalities

fatty filum terminale and syrinx are independent predictors of rectal terminal ganglion absence in male patients with complex ARMs.

关键词

Keywords

references

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Department of Neonatal Gastrointestinal Surgery, Key Laboratory of Child Development and Disorder of Ministry of Education, Chongqing Key Laboratory of Pediatrics, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children's Hospital of Chongqing Medical University

Department of Neonatal Gastrointestinal Surgery, Key Laboratory of Child Development and Disorders of Ministry of Education, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Children's Hospital of Chongqing Medical University

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