Effect of lifestyle modification during the whole process of entering and existing the plateau on high-altitude de-adaptation

Rui WANG; Jia ZHAO; Qifa LUO; Yongjun LUO

doi:10.16016/j.2097-0927.202308074

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Effect of lifestyle modification during the whole process of entering and existing the plateau on high-altitude de-adaptation

Military Medicine | 更新时间：2026-01-09

- Effect of lifestyle modification during the whole process of entering and existing the plateau on high-altitude de-adaptation
- Journal of Army Medical University Vol. 46, Issue 11, Pages: 1298-1305(2024)
- 作者机构：
  
  1.400038 重庆，陆军军医大学(第三军医大学)陆军卫勤训练基地军事医学地理学教研室
  2.751100 宁夏吴忠，中国人民解放军31670部队
- 作者简介：
- 基金信息：
  
  the General Program of National Natural Science Foundation of China(42377466);the Special Project of Second Comprehensive Scientific Investigation and Research on Qinghai-Tibet Plateau From Ministry of Science and Technology(2019QZKK0607)
- DOI：10.16016/j.2097-0927.202308074
  CLC： R195.1;R594.3
- Received：19 August 2023，
  
  Revised：2023-10-06，
  
  Published：15 June 2024
- 稿件说明：
移动端阅览
Rui WANG, Jia ZHAO, Qifa LUO, et al. Effect of lifestyle modification during the whole process of entering and existing the plateau on high-altitude de-adaptation[J]. Journal of Army Medical University, 2024, 46(11): 1298-1305.
DOI：

Rui WANG, Jia ZHAO, Qifa LUO, et al. Effect of lifestyle modification during the whole process of entering and existing the plateau on high-altitude de-adaptation[J]. Journal of Army Medical University, 2024, 46(11): 1298-1305. DOI： 10.16016/j.2097-0927.202308074.

摘要

目的

采用问卷调查出入高原全过程的生活方式对高原脱适应症(high-altitude de-adaptation，HADA)的影响，为防治HADA提供科学依据。

方法

采用病例-对照研究设计方案，以2021-2022年某单位集体从高原返回1~2周的1 751人为调查对象，获得有效问卷1 544份，根据高原脱适应症量表得分是否≥6分，将调查对象分为高原脱适应组(

=192)与对照组(

=1 352)。对研究对象的生活习惯与一般情况进行问卷调查，通过秩和检验比较2组调查对象之间的生活方式是否存在差异，采用非条件Logistic回归分析明确HADA的独立危险因素。

结果

头发脱落(19.95%)、嗜睡(16.58%)和疲倦(12.31%)为最常见的高原脱适应症症状；且进入高原前高盐饮食，在高原时吸烟、出现高原反应(

=1.893，95%

：1.142~3.137，

=0.013)、乘飞机离开高原(

=1.688，95%

：1.082~ 2.634，

=0.021)，离开高原后多饮茶、运动强度过高和睡眠不足均为HADA的独立危险因素。

结论

进入高原前清淡饮食、积极预防高原反应，在高原时戒烟、选择较慢的交通工具出入高原，离开高原后少饮茶、适量运动和保持睡眠充足可以有效降低HADA的发病风险。

Abstract

Objective

To investigate the effect of lifestyle on high-altitude de-adaptation (HADA) through questionnaire during the whole process of entering and existing the plateau in order to provide scientific basis for prevention and treatment of the disease.

Methods

A case-control trial was conducted on 1 751 participants from a certain unit who entered and existed the plateau together during 2021 and 2022. In 1 to 2 weeks after they returning from the plateau

they were surveyed

and finally

1 544 valid questionnaires were obtained. According to the score of the plateau deacclimation scale ≥6 or not

the subjects were divided into plateau deacclimation group (

=192) and control group (

=1 352). They were further surveyed for their lifestyles and general conditions. Rank sum test was used to analyze the differences of lifestyles between the 2 groups

and unconditional logistic regression analysis was employed to identify the independent risk factors of HADA.

Results

Hair loss (19.95%)

drowsiness (16.58%) and tiredness (12.31%) were the most common symptoms of HADA. High salt diet before entering the plateau

smoking at the plateau

altitude sickness (

=1.893

95%

: 1.142~3.137

=0.013)

leaving the plateau by plane (

=1.688

95%

: 1.082~2.634

=0.021)

and drinking much tea

excessive exercise intensity and insufficient sleep after leaving the plateau were independent risk factors for HADA.

Conclusion

Low salt diet before entering the plateau

active prevention for altitude sickness

smoking cessation at the plateau

taking a slower means of transportation to enter and leave the plateau

drinking less tea

moderate exercise intensity and keeping enough sleep after leaving the plateau can effectively reduce the risk of HADA.

关键词

Keywords

references

谢忠林, 王新全, 尧梦媛, 等. 高原脱适应症研究进展[J]. 人民军医, 2020, 63(10): 957-960. DOI: 10.3969/j.issn.1000-9736.2020.10.010.

XIE Z L, WANG X Q, YAO M Y, et al . Research progress of high altitude de-indication[J ] . People Mil Surg, 2020, 63(10): 957-960. DOI: 10.3969/j.issn.1000-9736.2020.10.010.

范勇, 刘小乐, 李相成, 等. 高原维稳部队返回平原后高原脱适应情况调查[J]. 现代预防医学, 2012, 39(8): 1863-1865, 1870. DOI: 10.3969/j.issn.1001-5248.2008.04.005.

FAN Y, LIU X L, LI X C, et al . Investigation onthe deadaptation response about the plateau duty forces returned to the Plains[J ] . Mod Prev Med, 2012, 39(8): 1863-1865, 1870. DOI: 10.3969/j.issn.1001-5248.2008.04.005.

丰丽英, 朱前勇, 王保健, 等. 医疗分队高原驻训后脱适应症发生情况调查[J]. 人民军医, 2017, 60(2): 114-117. DOI: 10.13919/j.issn.2095-6274.2016.06.005.

FENG L Y, ZHU Q Y, WANG B J, et al . Investigation on the occurrence of out-of-indications of medical teams after training at high altitude[J ] . People Mil Surg, 2017, 60(2): 114-117. DOI: 10.13919/j.issn.2095-6274.2016.06.005.

刘爽, 龙贤哲, 罗勇军. 高原脱适应症诊断及防治研究进展[J]. 人民军医, 2017, 60(9): 941-943. DOI: 10.3969/j.issn.1673-4130.2014.12.014.

LIU S, LONG X Z, LUO Y J. Research progress on diagnosis, prevention and treatment of plateau de-indications[J]. People Mil Surg, 2017, 60(9): 941-943. DOI: 10.3969/j.issn.1673-4130.2014.12.014.

王引虎, 周其全, 牛文忠, 等. 高原脱习服症预防研究[J]. 西南国防医药, 2013, 23(12): 1347-1350. DOI: 10.3969/j.issn.1004-0188.2013.12.030.

WANG Y H, ZHOU Q Q, NIU W Z, et al . Study on prevention of altitude unaccustomed disease[J ] . Med J Natl Defending Forces Southwest China, 2013, 23(12): 1347-1350. DOI: 10.3969/j.issn.1004-0188.2013.12.030.

秦天, 王文岚, 谭嘉懿, 等. 高压氧预适应对高原脱习服的保护作用研究[J]. 中国疗养医学, 2023, 32(6): 587-590. DOI: 10.13517/j.cnki.ccm.2023.06.006.

QIN T, WANG W L, TAN J Y, et al . Protective effect of hyperbaric oxygen preconditioning on plateau deacclimatization[J ] . Chin J Conval Med, 2023, 32(6): 587-590. DOI: 10.13517/j.cnki.ccm.2023.06.006.

邱友竹, 王旭萍. 急进高原环境对血管内皮功能的影响及其与急性高原病的关系[J]. 高原医学杂志, 2015, 25(4): 48. DOI: 10.11855/j.issn.0577-7402.2015.05.18.

QIU Y Z, WANG X P. Effects of rapid entrance into plateau area on the vascular endothelial function and the relationship to acute mountain sickness[J]. J High Alt Med, 2015, 25(4): 48. DOI: 10.11855/j.issn.0577-7402.2015.05.18.

HE B F, WANG J C, QIAN G S, et al . Analysis of high-altitude de-acclimatization syndrome after exposure to high altitudes: a cluster-randomized controlled trial[J ] . PLoS One, 2013, 8(5): e62072. DOI: 10.1371/journal.pone.0062072.

BAO M, ENGEL S A. Distinct mechanism for long-term contrast adaptation[J]. Proc Natl Acad Sci U S A, 2012, 109(15): 5898-5903. DOI: 10.1073/pnas.1113503109.

RISSO A, TURELLO M, BIFFONI F, et al . Red blood cell senescence and neocytolysis in humans after high altitude acclimatization[J ] . Blood Cells Mol Dis, 2007, 38(2):83-92. DOI: 10.1016/j.bcmd.2006.10.161.

HANSEN J, SANDER M. Sympathetic neural overactivity in healthy humans after prolonged exposure to hypobaric hypoxia[J]. J Physiol, 2003, 546(Pt 3): 921-929. DOI: 10.1113/jphysiol.2002.031765.

BAN K C, KOZAR R A. Protective role of p70S6K in intestinal ischemia/reperfusion injury in mice[J]. PLoS One, 2012, 7(7): e41584. DOI: 10.1371/journal.pone.0041584.

KAMBARA T, OHASHI K, SHIBATA R, et al . CTRP9 protein protects against myocardial injury following ischemia-reperfusion through AMP-activated protein kinase (AMPK)-dependent mechanism[J ] . J Biol Chem, 2012, 287(23): 18965-18973. DOI: 10.1074/jbc.M112.357939.

MA X C, LIU H Y, FOYIL S R, et al . Impaired autophagosome clearance contributes to cardiomyocyte death in ischemia/reperfusion injury[J ] . Circulation, 2012, 125(25): 3170-3181. DOI: 10.1161/CIRCULATIONAHA.111.041814.

NGOH G A, FACUNDO H T, HAMID T, et al . Unique hexosaminidase reduces metabolic survival signal and sensitizes cardiac myocytes to hypoxia/reoxygenation injury[J ] . Circ Res, 2009, 104(1): 41-49. DOI: 10.1161/CIRCRESAHA.108.189431.

PACZULA A, WIECEK A, PIECHA G. Cardiotonic steroids—a possible link between high-salt diet and organ damage[J]. Int J Mol Sci, 2019, 20(3): 590. DOI: 10.3390/ijms20030590.

HARTLEY L, FLOWERS N, HOLMES J, et al . Green and black tea for the primary prevention of cardiovascular disease[J ] . Cochrane Database Syst Rev, 2013, 2013(6): CD009934. DOI: 10.1002/14651858.CD009934.pub2.

ZHANG Z C, ZHANG X C, BI K Y, et al . Potential protective mechanisms of green tea polyphenol EGCG against COVID-19[J ] . Trends Food Sci Technol, 2021, 114: 11-24. DOI: 10.1016/j.tifs.2021.05.023.

李彬, 李年华, 高亮, 等. 急慢性高原反应症状体征影响因素及相关性探讨[J]. 西北国防医学杂志, 2016, 37(8): 494-496. DOI: 10.16021/j.cnki.1007-8622.2016.08.002.

LI B, LI N H, GAO L, et al . Influential factors and its correlation of signs and symptoms of acute and chronic high altitude reaction[J ] . Med J Natl Defending Forces Northwest China, 2016, 37(8): 494-496. DOI: 10.16021/j.cnki.1007-8622.2016.08.002.

NEAL B, WU Y F, FENG X X, et al . Effect of salt substitution on cardiovascular events and death[J ] . N Engl J Med, 2021, 385(12): 1067-1077. DOI: 10.1056/nejmoa2105675.

张鹏海, 陈婷, 张鹏天. 有氧健身运动缓解大学生脱适应的对比研究[J]. 西藏科技, 2011(9): 16-18. DOI: 10.3969/j.issn.1004-3403.2011.09.006.

ZHANG P H, CHEN T, ZHANG P T. A contrastive study of aerobic exercise alleviating college students' desacclimatization[J]. Tibet Sci Technol, 2011(9): 16-18. DOI: 10.3969/j.issn.1004-3403.2011.09.006.

张文, 陈雷, 刘守东, 等. 新的疗养模式对高原脱适应期官兵身心状态的影响[J]. 中国疗养医学, 2023, 32(1): 16-19. DOI: 10.13517/j.cnki.ccm.2023.01.003.

ZHANG W, CHEN L, LIU S D, et al . The new recuperation model Influence the physical and mental state of soldiers during the plateau de-adaptation period[J ] . Chin J Conval Med, 2023, 32(1): 16-19. DOI: 10.13517/j.cnki.ccm.2023.01.003.

张钢, 李鹏, 王开发, 等. 以相对心率为指标的高原适宜劳动强度评价方法研究[J]. 第三军医大学学报, 2020, 42(9): 948-952. DOI: 10.16016/j.1000-5404.201912008.

ZHANG G, LI P, WANG K F, et al . Evaluation of optimal labor intensity with relative heart rate at plateau[J ] . J Third Mil Med Univ, 2020, 42(9): 948-952. DOI: 10.16016/j.1000-5404.201912008.

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