Relationship of serum NLR and PLR levels with early renal damage in patients with pre-eclampsia

Wenli ZHU; Yanhui LOU; Yuling ZHAO

doi:10.16016/j.2097-0927.202308056

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Relationship of serum NLR and PLR levels with early renal damage in patients with pre-eclampsia

Clinical Medicine | 更新时间：2026-01-09

- Relationship of serum NLR and PLR levels with early renal damage in patients with pre-eclampsia
- Journal of Army Medical University Vol. 46, Issue 2, Pages: 190-195(2024)
- 作者机构：
  
  067000 河北承德，承德市中心医院产科
- 作者简介：
- 基金信息：
  
  the Project of Medical Scientific Research Plan of Hebei Province(20170883);the Project of Science and Technology Support Plan of Chengde City(202102A014)
- DOI：10.16016/j.2097-0927.202308056
  CLC： R446.111;R692;R714.245
- Received：18 August 2023，
  
  Revised：2023-09-28，
  
  Published：30 January 2024
- 稿件说明：
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Wenli ZHU, Yanhui LOU, Yuling ZHAO. Relationship of serum NLR and PLR levels with early renal damage in patients with pre-eclampsia[J]. Journal of Army Medical University, 2024, 46(2): 190-195.
DOI：

Wenli ZHU, Yanhui LOU, Yuling ZHAO. Relationship of serum NLR and PLR levels with early renal damage in patients with pre-eclampsia[J]. Journal of Army Medical University, 2024, 46(2): 190-195. DOI： 10.16016/j.2097-0927.202308056.

摘要

目的

探讨中性粒细胞/淋巴细胞比值(neutrophil to lymphocyte ratio，NLR)、血小板/淋巴细胞比值(platelet to lymphocyte ratio，PLR)与子痫前期(pre-eclampsia，PE)患者早期肾损伤的关系。

方法

选取2020年1月至2022年2月本院产科收治的98例PE患者(PE组)与113例妊娠期高血压(gestational hypertension，GH)患者(GH组)，另将68例在我院定期做孕检的健康孕妇作为对照组。记录3组孕妇血清NLR、PLR、肾功能指标[尿素氮(urea nitrogen，BUN)、血肌酐(serum creatinine，Scr)、胱抑素C(cystatin C，Cys-C)以及肾小球滤过率(estimate glomerular filtration rate，eGFR)]。根据是否发生肾损伤分为未发生肾损伤组(56例)与已发生肾损伤组(42例)。分析NLR、PLR与肾功能指标的关系，并进行危险因素分析以及分析NLR、PLR对PE患者发生早期肾损伤的预测价值。

结果

GH组与PE组的NLR、BUN、Scr、Cys-C、24 h尿蛋白水平显著高于对照组，且PE组明显高于GH组(

0.05)；PLR、eGFR水平显著低于对照组，且PE组明显低于GH组(

0.05)。Pearson相关性分析结果显示，NLR与BUN、Scr、Cys-C、24 h尿蛋白呈正相关，与eGFR呈负相关；PLR与BUN、Scr、Cys-C、24 h尿蛋白呈负相关，与eGFR呈正相关。多因素分析结果显示，重度PE、NLR、PLR、24 h尿蛋白、eGFR是影响PE患者发生早期肾损伤的主要危险因素(

0.05)。受试者工作特征曲线分析发现，NLR、PLR预测PE患者发生早期肾损伤的截断值分别为2.71、103.26，曲线下面积分别为0.896、0.809，敏感度分别为93.28%、90.81%，特异度分别为80.17%、80.01%。

结论

NLR、PLR水平升高与PE患者早期肾损伤有关，是PE患者发生早期肾损伤的危险因素，且对PE患者的早期肾损伤具有较高的预测价值。

Abstract

Objective

To investigate the relationship of neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) with early renal damage in pre-eclampsia (PE) patients.

Methods

A total of 98 PE patients (PE group) and 113 patients with gestational hypertension (GH

GH group) admitted to our hospital from January 2020 to February 2022 were recruited

and another 68 healthy pregnant women who underwent regular pregnancy examination in our hospital were enrolled as control group. Serum NLR

PLR

and renal function indicators [urea nitrogen (BUN)

serum creatinine (Scr)

cystatin C (Cys-C) and estimate glomerular filtration rate (eGFR)] were recorded in the 3 groups. According to whether renal injury occurred

the patients of the PE group were divided into non-renal injury subgroup (56 cases) and renal injury group (42 cases). The relationships of NLR and PLR with renal function indicators were analyzed

and the results were further analyzed for the risk factors. The predictive values of NLR and PLR for early renal injury in PE patients were analyzed.

Results

The levels of NLR

BUN

Scr

Cys-C and 24-h urine protein were significantly higher in the GH group and the PE group than the control group(

0.05)

and those in the PE group were obviously higher than those in the GH group (

0.05). The levels of PLR and eGFR were statistically lower in the GH group and PE group than those in the the control group

and that in the PE group was decreased than that in the GH group (

0.05). Pearson correlation analysis showed that NLR was positively correlated with BUN

Scr

Cys-C and 24-h urine protein

and negatively with eGFR

while PLR was negatively correlated with above renal function indicators

and positively with eGFR. Multivariate analysis indicated that severe PE

NLR

PLR

24-h urine protein and eGFR were the main risk factors for early renal injury in PE patients (

0.05). Receiver operating characteristic (ROC) curve analysis showed that the cut-off values of NLR and PLR for predicting early renal injury in PE patients were 2.71 and 103.26

the area under the curve value was 0.896 and 0.809

the sensitivity was 93.28 % and 90.81 %

and the specificity was 80.17% and 80.01%

respectively.

Conclusion

Elevated levels of NLR and PLR are associated with early renal damage in PE patients

and they are risk factors and have high predictive values for early kidney damage in PE patients.

关键词

Keywords

references

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