Characteristics of gut microbiota in middle-aged and elderly overweight/obese women based on body composition data

Mengting CHEN; Xiaohong ZHANG; Jing YANG; Liqiang QIN; Wei CHEN

doi:10.16016/j.2097-0927.202303177

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Characteristics of gut microbiota in middle-aged and elderly overweight/obese women based on body composition data

Monographic Reports: Nutritional intervention for chronic diseases | 更新时间：2026-01-09

- Characteristics of gut microbiota in middle-aged and elderly overweight/obese women based on body composition data
- Journal of Army Medical University Vol. 45, Issue 15, Pages: 1582-1588(2023)
- 作者机构：
  
  1.215123 江苏苏州，苏州大学：附属第一医院内分泌科
  2.215123 江苏苏州，苏州大学：公共卫生学院营养与食品卫生学教研室
  3.215123 江苏苏州，苏州大学：附属第一医院临床营养科
  4.215123 江苏苏州，苏州大学：第一临床医学院内分泌病学教研室
  5.100730 北京，中国医学科学院北京协和医院临床营养科
- 作者简介：
- 基金信息：
  
  the National Natural Science Foundation for Young Scholars of China(81803216);the Training Project of "National Tutorial System" for Health Young Backbone Talents in Suzhou(Qngg2021004)
- DOI：10.16016/j.2097-0927.202303177
  CLC： R195.1;R446.5;R589.2
- Received：30 March 2023，
  
  Revised：2023-05-12，
  
  Published：15 August 2023
- 稿件说明：
移动端阅览
Mengting CHEN, Xiaohong ZHANG, Jing YANG, et al. Characteristics of gut microbiota in middle-aged and elderly overweight/obese women based on body composition data[J]. Journal of Army Medical University, 2023, 45(15): 1582-1588.
DOI：

Mengting CHEN, Xiaohong ZHANG, Jing YANG, et al. Characteristics of gut microbiota in middle-aged and elderly overweight/obese women based on body composition data[J]. Journal of Army Medical University, 2023, 45(15): 1582-1588. DOI： 10.16016/j.2097-0927.202303177.

摘要

目的

探索中老年超重/肥胖女性人群中肠道菌群与人体脂肪、肌肉成分的相关性。

方法

2019年9月至2020年10月在苏州市各个社区招募中老年超重/肥胖女性75名，收集基本信息，完成膳食调查，采用老年体力活动量表(physical activity scale for the elderly，PASE)评估体力活动量，采用生物电阻抗法测量体成分数据，收集志愿者粪便样本并进行16S rRNA测序，筛选菌群，利用统计学软件建立多元线性回归分析模型，并引入年龄、身高、体力活动量、蛋白质摄入量、脂肪摄入量、碳水化合物摄入量进行校正，分析肠道菌群与体脂肪及肌肉相关指标的关系。

结果

多元线性回归分析筛选出24个操作分类单元建立模型。校正后结果提示，在脂肪方面，

EtOH

8科及部分菌属、费氏刺骨鱼菌属(

Epulopiscium

)与体脂质量(body fat，FAT)正相关，颤螺菌属(

Oscillospira

)、乳球菌属(

Lactococcus

)、斯卡多维亚氏菌属(

Scardovia

)及毛螺菌科(

Lachnospiraceae

)部分菌属与脂肪质量百分比(fat mass ratio，FMR)负相关。在肌肉方面，除

Lachnobacterium

属与肌肉质量(soft lean mass，SLM)负相关外，栖热菌科(

Thermaceae

)、亚栖热菌属(

Meiothermus

)及库克菌属(

Kocuria

)等14个菌群与SLM正相关。

结论

中老年超重/肥胖女性肠道菌群与体脂肪及肌肉相关指标显著相关，部分特定菌群可能对脂肪或肌肉具有积极的调节作用。

Abstract

Objective

To investigate the correlation of gut microbiota with body composition of fat and muscle in middle-aged and elderly overweight/obese women.

Methods

A total of 75 middle-aged and elderly overweight/obese women were subjected from communities in Suzhou City from September 2019 to October 2020. Their basic information were collected

and dietary survey was completed. Physical activity scale for the elderly (PASE) was used to assess the intensity of physical activity. Body composition data was measured by bioelectrical impedance measurement. Fecal samples were collected from some volunteers from them and 16S rRNA gene sequencing was conducted to screen the bacterial community. Statistical software was used to establish multiple linear regression analysis models to analyze the correlation between gut microbiota and the relevant indexes of human fat and muscle

adjusted for age

height

physical activity

protein intake

fat intake and carbohydrate intake as covariates.

Results

There were 24 operational taxonomic units (OTU) screened out with multiple linear regression models. The adjusted results showed

EtOH

8 family and some genera of the family

Epulopiscium

were positively correlated with body fat mass (FAT)

while

Oscillospira

Lactococcus

Scardovia

and some genera of

Trichospira

were negatively correlated with fat mass ratio (FMR). In terms of muscle

Lachnobacterium

was negatively correlated with soft lean mass (SLM)

while the other 14 flora

including

Thermaceae

Meiothermus

and

Kocuria

etc

. were positively correlated with SLM.

Conclusion

Gut microbiota is significantly correlated with body fat and muscle related indicators in middle-aged and elderly overweight/obese women. Some specific flora may have positive effects on fat or muscle.

关键词

Keywords

references

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