Effect of nutritional therapy on body composition in overweight/obese children with systemic lupus erythematosus

Jiongxian YANG; Junmei ZHANG; Chao LI; Caifeng LI

doi:10.16016/j.2097-0927.202303120

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Effect of nutritional therapy on body composition in overweight/obese children with systemic lupus erythematosus

Monographic Reports: Nutritional intervention for chronic diseases | 更新时间：2026-01-09

- Effect of nutritional therapy on body composition in overweight/obese children with systemic lupus erythematosus
- Journal of Army Medical University Vol. 45, Issue 15, Pages: 1621-1626(2023)
- 作者机构：
  
  1.100045 北京，国家儿童医学中心，首都医科大学附属北京儿童医院：保健中心
  2.100045 北京，国家儿童医学中心，首都医科大学附属北京儿童医院：风湿科
- 作者简介：
- 基金信息：
- DOI：10.16016/j.2097-0927.202303120
  CLC： R459.3;R725.892;R725.932.4
- Received：20 March 2023，
  
  Revised：2024-04-23，
  
  Published：15 August 2023
- 稿件说明：
移动端阅览
Jiongxian YANG, Junmei ZHANG, Chao LI, et al. Effect of nutritional therapy on body composition in overweight/obese children with systemic lupus erythematosus[J]. Journal of Army Medical University, 2023, 45(15): 1621-1626.
DOI：

Jiongxian YANG, Junmei ZHANG, Chao LI, et al. Effect of nutritional therapy on body composition in overweight/obese children with systemic lupus erythematosus[J]. Journal of Army Medical University, 2023, 45(15): 1621-1626. DOI： 10.16016/j.2097-0927.202303120.

摘要

目的

探讨营养治疗对正在应用激素治疗的超重/肥胖系统性红斑狼疮(systemic lupus erythematosus，SLE)患儿体成分的影响。

方法

招募2018年12月至2022年6月北京儿童医院应用糖皮质激素(glucocorticoid

GC)治疗的7~18岁超重/肥胖SLE患儿。符合纳入、排除标准并签署知情同意书后，首先全部纳入观察组。观察组给予营养治疗，能量目标为身高对应50百分位数年龄的轻度体力活动推荐摄入量的基础上减少10%；随访24周后，为防止患儿间信息交流对研究的影响，暂中断入组6个月以上。后续按照纳入、排除标准继续完成对照组入组，对照组给予营养教育。各组均在入组后4、12、24周进行门诊随访，主要监测指标: 人体学测量、实验室检查，并记录糖皮质激素用量。

结果

最终纳入60例患儿，其中观察组40例，对照组20例。两组间基线数据(性别、年龄、体质量指数、GC用量等)差异均无统计学意义。两组患儿基线时的体脂率(body fat percentage

BFP)与内脏脂肪面积(visceral fat area，VFA)差异无统计学意义；随访12、24周后，观察组BFP和VFA均较基线时显著降低(

0.05)，对照组BFP和VFA均较基线时显著升高(

0.05)；两组患儿12、24周时GC用量均较基线显著减少(

0.05)，但两组间差异无统计学意义(

0.05)。

结论

营养治疗可改善激素治疗过程中超重/肥胖SLE患儿的体脂率和内脏脂肪面积。

Abstract

Objective

To investigate the effects of nutritional therapy on body composition in overweight/obese children with systemic lupus erythematosus (SLE) during the treatment with glucocorticoid (GC).

Methods

The SLE children (7-18 years old) who received GC treatment and were overweight/obese admitted in our hospital from December 2018 to June 2022 were recruited in this study. After meeting the inclusion and exclusion criteria and signing the informed consent form

all subjects were included in the observation group. Then

nutrition therapy was given with an energy target of the 90% of the level recommended by the Dietary Guidelines for Chinese Residents according to ages. After the intervention for 24 weeks

a break for 6 months was given to these subject in order to avoid information exchange among them. Subsequently

our inclusion and exclusion criteria were employed again to recruit the subjects in the control group. The children from the control group were only given nutrition education. All these participants were followed up by clinic visits at 4

12 and 24 weeks after intervention. Main observation indicators included anthropometric measurement

results of laboratory tests

and dosage of GC.

Results

There were 60 SLE children enrolled in this study

and 40 in the observation group and 20 in the control group. No statistical differences were found in baseline data (sex ratio

age

BMI and dosage of GC) between the 2 groups. No differences were seen in body fat percentage (BPF) and visceral fat area (VFA) at baseline between the 2 groups. But the 2 indicators were decreased in the observation group (

0.05)

and increased in the control group (

0.05) in 12 and 24 weeks after intervention. The dosage of GC was declined in both group in 12 and 24 weeks (

0.05)

but there was no difference between the 2 groups (

0.05).

Conclusion

Nutritional therapy can improve BFP and VFA in overweight/obese SLE children during the treatment with GC.

关键词

Keywords

references

FAVA A, PETRI M. Systemic lupus erythematosus: diagnosis and clinical management[J]. J Autoimmun, 2019, 96: 1-13. DOI: 10.1016/j.jaut.2018.11.001.

REES F, DOHERTY M, GRAINGE M J, et al . The worldwide incidence and prevalence of systemic lupus erythematosus: a systematic review of epidemiological studies[J ] . Rheumatology (Oxford), 2017, 56(11): 1945-1961. DOI: 10.1093/rheumatology/kex260.

WHITNEY D G. Prevalence of high-burden medical conditions among young and middle-aged adults with pediatric-onset medical conditions: findings from US private and public administrative claims data[J]. Int J Health Policy Manag, 2019, 8(11): 629-635. DOI: 10.15171/ijhpm.2019.62.

YOON S, KANG D H, CHOI T Y. Psychiatric symptoms in systemic lupus erythematosus: diagnosis and treatment[J]. J Rheum Dis, 2019, 26(2): 93. DOI: 10.4078/jrd.2019.26.2.93.

POCOVI-GERARDINO G, CORREA-RODRÍGUEZ M, CALLEJAS-RUBIO J L, et al . Dietary intake and nutritional status in patients with systemic lupus erythematosus[J ] . Endocrinol Diabetes Y Nutr, 2018, 65(9): 533-539. DOI: 10.1016/j.endinu.2018.05.009.

COZIER Y C, BARBHAIYA M, CASTRO-WEBB N, et al . A prospective study of obesity and risk of systemic lupus erythematosus (SLE) among Black women[J ] . Semin Arthritis Rheum, 2019, 48(6): 1030-1034. DOI: 10.1016/j.semarthrit.2018 .10.004.

中国营养学会. 中国居民膳食营养素参考摄入量速查手册: 2013版[M]. 北京: 中国标准出版社, 2014: 33-38.

Chinese Nutrition Society. Chinese dietary reference intake—handbook (2013)[M]. Beijing: Standards Press of China, 2014: 33-38.

FANOURIAKIS A, KOSTOPOULOU M, ALUNNO A, et al . 2019 update of the EULAR recommendations for the management of systemic lupus erythematosus[J ] . Ann Rheum Dis, 2019, 78(6): 736-745. DOI: 10.1136/annrheumdis-2019-215089.

中国医疗保健国际交流促进会营养与代谢管理分会, 中国营养学会临床营养分会, 中华医学会糖尿病学分会, 等. 中国超重/肥胖医学营养治疗指南(2021)[J]. 中国医学前沿杂志(电子版), 2021, 13(11): 1-55. DOI: 10.12037/YXQY.2021.11-01.

China International Exchange and Promotive Association for Medical and Health Care, Branch of Clinical Nutrition of Chinese Nutrition Society, Diabetic Branch of Chinese, et al . Guidelines for medical nutrition treatment of overweight/obesity in China (2021)[J ] . Chin J Front Med Sci Electron Version, 2021, 13(11): 1-55. DOI: 10.12037/YXQY.2021.11-01.

潘长鹭, 栗达, 赵文利, 等. 饮食及运动综合干预对肥胖儿童人体成分变化的影响[J]. 中国医刊, 2020, 55(5): 569-571. DOI: 10.3969/j.issn.1008-1070.2020.05.031.

PAN C L, LI D, ZHAO W L, et al . Effect of comprehensive int ervention of diet and exercise on the changes of body composition of obese children[J ] . Chin J Med, 2020, 55(5): 569-571. DOI: 10.3969/j.issn.1008-1070.2020.05.031.

张秀艳, 高晓伟, 李秋宝, 等. 运动与营养疗法对肥胖儿童的干预效果[J]. 国际护理学杂志, 2021, 40(10): 1775-1778. DOI: 10.3760/cma.j.cn221370-20190829-00516.

ZHANG X Y, GAO X W, LI Q B, et al . Intervention effect of exercise and nutrition therapy on obese children[J ] . Int J Nurs, 2021, 40(10): 1775-1778. DOI: 10.3760/cma.j.cn221370-20190829-00516.

李毓清. 营养和运动综合治疗单纯性肥胖儿童的效果分析[J]. 中国实用医药, 2021, 16(11): 205-207. DOI: 10.14163/j.cnki.11-5547/r.2021.11.075.

LI Y Q. Analysis of the effect of comprehensive treatment of nutrition and exercise on simple obese children[J]. China Pract Med, 2021, 16(11): 205-207. DOI: 10.14163/j.cnki.11-5547/r.2021.11.075.

SUN C, KOVACS P, GUIU-JURADO E. Genetics of body fat distribution: comparative analyses in populations with European, Asian and African ancestries[J]. Genes, 2021, 12(6): 841. DOI: 10.3390/genes12060841.

LIU A L, BYRNE N M, KAGAWA M, et al . Ethnic differences in the relationship between body mass index and percentage body fat among Asian children from different backgrounds[J ] . Br J Nutr, 2011, 106(9): 1390-1397. DOI: 10.1017/s0007114511001681.

GREENAN-BARRETT J, DOOLAN G, SHAH D, et al . Biomarkers associated with organ-specific involvement in juvenile systemic lupus erythematosus[J ] . Int J Mol Sci, 2021, 22(14): 7619. DOI: 10.3390/ijms22147619.

QUAN W, AN J, LI G, et al. Th cytokine profile in childhood-onset systemic lupus erythematosus[J ] . BMC Pediatrics, 2021, 21(1): 187. DOI:10.1186/s12887-021-02659-3.

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