Correlation of decoy receptor 2 with clinical and pathological characteristics of acute kidney injury

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Correlation of decoy receptor 2 with clinical and pathological characteristics of acute kidney injury

Clinical Medicine | 更新时间：2026-01-09

- Correlation of decoy receptor 2 with clinical and pathological characteristics of acute kidney injury
- Journal of Army Medical University Vol. 46, Issue 5, Pages: 484-490(2024)
- 作者机构：
  
  400042 重庆，陆军特色医学中心肾内科
- 作者简介：
- 基金信息：
  
  the Joint Medical Research Project for Young Scholars of Chongqing Science and Technology Commission and Chongqing Health Commission(2023QNXM011);the Open Project of State Key Laboratory of Trauma, Burns and Combined Injury(SKLKF202202)
- DOI：10.16016/j.2097-0927.202303108
  CLC： R362;R446.12;R692.02
- Received：16 March 2023，
  
  Revised：2023-06-21，
  
  Published：15 March 2024
- 稿件说明：
移动端阅览
Xiangling YI, Jia LUO, Lihua BAI, et al. Correlation of decoy receptor 2 with clinical and pathological characteristics of acute kidney injury[J]. Journal of Army Medical University, 2024, 46(5): 484-490.
DOI：

Xiangling YI, Jia LUO, Lihua BAI, et al. Correlation of decoy receptor 2 with clinical and pathological characteristics of acute kidney injury[J]. Journal of Army Medical University, 2024, 46(5): 484-490. DOI： 10.16016/j.2097-0927.202303108.

摘要

目的

2

拟探讨诱骗受体2(decoy receptor 2，DcR2)与急性肾损伤(acute kidney injury，AKI)患者临床指标与病理损伤的相关性。

方法

2

纳入陆军特色医学中心肾内科2018年1月至2021年11月51例经肾活检诊断AKI患者及对照患者20例。ELISA检测患者尿DcR2/Cr水平；相关性分析尿DcR2/Cr水平与肾小管DcR2表达量、肾功指标之间的相关性；利用免疫组化检测DcR2表达与定位，免疫荧光共染分析DcR2与肾小管间质纤维化标志物α-SMA、FSP1之间的共定位关系。

结果

2

AKI组尿DcR2/Cr显著高于对照组(

P

＜0.05)；DcR2特异性高表达于AKI患者肾小管上皮细胞，DcR2表达阳性率高于对照组(

P

＜0.01)；尿DcR2/Cr与尿素氮、肌酐呈正相关(

r

=0.426

P

＜0.05;

r

=0.462

P

＜0.05)，与eGFR呈负相关(

r

=0.536

P

＜0.01)；AKI组患者肾组织DcR2表达量与尿DcR2/Cr、肾小管萎缩及间质纤维化程度呈正相关(

r

=0.808、0.457，

P

＜0.01)；DcR2阳性的肾小管细胞周围高表达纤维化标志物α-SMA与FSP-1。

结论

2

AKI患者尿DcR2/Cr及肾组织DcR2表达变化与肾功能指标及肾组织慢性损伤密切相关，提示DcR2或可作为评估AKI损伤及预后的潜在生物标志物。

Abstract

Objective

2

To investigate the correlation between decoy receptor 2 (DcR2) and clinical indicators and pathological damage in patients with acute kidney injury (AKI).

Methods

2

A total of 51 AKI patients diagnosed with renal biopsy and 20 healthy controls admitted to our department between January 2018 and November 2021 were recruited in this study. ELISA was used to measure their urinary DcR2/Cr levels. Correlations of urinary DcR2/Cr levels with renal tubular DcR2 expression and renal function indicators were analyzed. Immunohistochemical assay was employed for DcR2 expression and location

and immunofluorescence co-staining was performed to analyze the colocalization of DcR2 and fibrotic markers (α-SMA and FSP1).

Results

2

Urinary DcR2/Cr was significa

ntly higher in the AKI group than the control group (

P

<

0.05)

and DcR2 was specifically highly expressed in the tubular cells

and the positive rate of DcR2 expression was higher in AKI patients than the control group (

P

<

0.01). Urinary DcR2/Cr levels were positively correlated with urea nitrogen and creatinine (

r

=0.426

P

<

0.05;

r

=0.462

P

<

0.05)

and negatively correlated with estimated glomerular filtration rate (eGFR) (

r

=0.536

P

<

0.01). Renal DcR2 expression level was positively correlated with urinary DcR2/Cr levels

tubular atrophy and severity of interstitial fibrosis in AKI patients (

r

=0.808

r

=0.457

P

<

0.01). Moreover

fibrotic markers α-SMA and FSP-1 were highly expressed around the DcR2-positive renal tubular cells.

Conclusion

2

The changes in urinary DcR2/Cr levels and renal DcR2 expression level are closely associated with renal function indicators and chronic renal injury in AKI patients

suggesting that DcR2 could be possibly used as a potential biomarker to assess kidney injury and prognosis.

关键词

Keywords

references

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