Outbreak of severe acute hepatitis of unknown cause in children in 2022: analysis of plausible pathogenic mechanism
- Journal of Army Medical University Vol. 45, Issue 5, Pages: 373-379(2023)
- 作者机构：
400038 重庆，陆军军医大学(第三军医大学)第一附属医院感染病科，全军感染病研究所
- 作者简介：
- 基金信息：the Pre-research Project of Army Medical University(2018XYY10);the Project of Army Dual Discipline Construction(SZJYCX001)
DOI：10.16016/j.2097-0927.202211036
CLC： R519.9;R725.126Received：07 November 2022，
Revised：2022-11-30，
Published：15 March 2023
- 稿件说明：
移动端阅览
Guohong DENG, Tuo SHI. Outbreak of severe acute hepatitis of unknown cause in children in 2022: analysis of plausible pathogenic mechanism[J]. Journal of Army Medical University, 2023, 45(5): 373-379.
Guohong DENG, Tuo SHI. Outbreak of severe acute hepatitis of unknown cause in children in 2022: analysis of plausible pathogenic mechanism[J]. Journal of Army Medical University, 2023, 45(5): 373-379. DOI： 10.16016/j.2097-0927.202211036.
摘要
截至2022年11月，欧洲地区共22个国家累计报道不明原因儿童严重急性肝炎病例572例。在病例中最常检出的病原体为人腺病毒和新型冠状病毒。研究者们针对这两种病原体提出了可能引起发病的病因假说，但具体病因和致病机制仍尚未明确。本文从病原学及免疫病理的角度对可能引起此次肝炎疫情的致病机制进行了分析，为调查致病机制提供思路。
Abstract
As of November 2022
22 countries in Europe have reported 572 cases of severe acute hepatitis in children with unknown causes. The most common pathogens tested are human adenovirus and SARS-CoV-2. Therefore
the researchers have proposed hypotheses about the possible etiological hypothesis of these 2 pathogens
but the existing test results cannot clarify the specific etiology and pathogenic mechanism yet. In this article
we aims to analyze the plausible pathogenic mechanism from the perspective of etiology and immunopathology in order to provide ideas for investigating the pathogenic mechanism.
关键词
Keywords
references
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