Comparison of cerebral oxygen saturation values measured by different brands of near-infrared spectrometers under hypoxic conditions: a randomized controlled trial in healthy volunteers

Yang LI; Taotao PENG; Dukun ZUO; Hong LI

doi:10.16016/j.2097-0927.202209257

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Comparison of cerebral oxygen saturation values measured by different brands of near-infrared spectrometers under hypoxic conditions: a randomized controlled trial in healthy volunteers

Military Medicine | 更新时间：2026-01-09

- Comparison of cerebral oxygen saturation values measured by different brands of near-infrared spectrometers under hypoxic conditions: a randomized controlled trial in healthy volunteers
- Journal of Army Medical University Vol. 45, Issue 8, Pages: 772-779(2023)
- 作者机构：
  
  400037 重庆, 陆军军医大学(第三军医大学)第二附属医院麻醉科
- 作者简介：
- 基金信息：
  
  the National Key Research and Development Program(2018YFC0117200)
- DOI：10.16016/j.2097-0927.202209257
  CLC： R197.13;R319;R446.112
- Received：27 September 2022，
  
  Revised：2022-10-16，
  
  Published：30 April 2023
- 稿件说明：
移动端阅览
Yang LI, Taotao PENG, Dukun ZUO, et al. Comparison of cerebral oxygen saturation values measured by different brands of near-infrared spectrometers under hypoxic conditions: a randomized controlled trial in healthy volunteers[J]. Journal of Army Medical University, 2023, 45(8): 772-779.
DOI：

Yang LI, Taotao PENG, Dukun ZUO, et al. Comparison of cerebral oxygen saturation values measured by different brands of near-infrared spectrometers under hypoxic conditions: a randomized controlled trial in healthy volunteers[J]. Journal of Army Medical University, 2023, 45(8): 772-779. DOI： 10.16016/j.2097-0927.202209257.

摘要

目的

通过健康志愿者降氧试验对比INVOS 5100C(美敦力)

EGOS-600(爱琴)和BRS-1(中科搏锐)脑氧测量值的变化情况，仪器的一致性、相关性以及检测关键去饱和事件的能力。

方法

2021年12月6日至2022年1月18日，招募陆军军医大学第二附属医院健康志愿者20名。采用随机数字表法将受试者分为两组，其中E组使用INVOS 5100C和EGOS-600的单个传感器，B组使用INVOS 5100C和BRS-1的传感器，每组10人。将各自的单个传感器贴于受试者前额后，通过调节吸入氮气和氧气的比例来诱导和逆转缺氧，并连续记录局部脑组织氧饱和度(regional cerebral oxygen saturation，rSO

)，受试者的心率(heart rate，HR)、脉搏氧饱和度(pulse oxygen saturation，SPO

)随时间的变化情况。统计方法使用Wilcoxon检验评估各设备之间rSO

基线值及变化情况。Bland-Altman和Deming回归分析两组仪器的一致性及相关性。受试者工作特征曲线(receiver operator characteristic curve

ROC)分析不同仪器检测低氧的效能。

结果

所有设备都对吸入氧浓度的变化做出了相似的反应。①EGOS-600和BRS-1的rSO

变化幅度及速率均小于INVOS 5100C，INVOS 5100C、EGOS-600和BRS-1的ΔrSO

分别为(16%~34.15%)、(6%~20.81%)和(5%~23.81%)，绝对中位数变化率分别为(2.81~4.40%/min)、(1.50~2.14%/min)及(1.77~2.41%/min)。②Bland-Altman分析显示EGOS-600和BRS-1与INVOS 5100C的差异均值分别为5.7、2.5；Deming回归显示Person系数分别为0.722 4、0.845 9，

0.001，与INVOS 5100C的一致性及相关性均较好。③以INVOS 5100C相对降低10%、20%和50%的绝对值作为关键的干预性rSO

阈值方面，EGOS-600检出率为90%、48%和40%，BRS-1检出率为80%、48%和50%。④ROC结果显示EGOS-600和BRS-1的AUC值分别为0.893、0.715，缺氧预测阈值(cut-off)分别为59.3%、56%。

结论

EGOS-600和BRS-1对氧合变化的反应与INVOS 5100C相似，相关性及一致性较好，可以准确地预测脑氧变化。

Abstract

Objective

By comparing the differences in cerebral oxygen parameters with 3 brands of near-infrared spectrometers

INVOS 5100C (Medtronic)

EGOS-600 (Aegean) and BRS-1 (Casibrain Technology)

to investigate their consistency

correlation and ability to detect key desaturation events in healthy volunteers in a hypoxic condition.

Methods

From December 6

2021 to January 18

2022

20 healthy volunteers were recruited from our hospital. They were randomly divided into group E (a single sensor of INVOS 5100C at the left forehead and that of EGOS-600 at the right) and group B (INVOS 5100C and BRS-1

as the other group)

with 10 subjects in each group. After the sensors were applied to the forehead of the subject

hypoxia was induced and reversed by adjusting the ratio of inhaled nitrogen to oxygen. Regional cerebral oxygen saturation (rSO

)

heart rate and pulse oxygen saturation (SPO

) were continuously monitored and recorded in the whole process. Wilcoxon test was used to assess the baseline value and changes in rSO

between different devices. Bland-Altman and Deming regression analyses were employed to analyze the consistency and correlation between the 2 devices. Receiver operating characteristic (ROC) curve was plotted to analyze the performance of the different devices in detection of hypoxia.

Results

All 3 devices responded similarly to the changes in inhaled oxygen concentration. ① The magnitude and rate of changes in rSO

for EGOS-600 and BRS-1 were less than those of INVOS 5100C. The ΔrSO

for INVOS 5100C

EGOS-600 and BRS-1 was 16%~34.15%

6%~20.81% and 5%~23.81%

with an absolute median rate of change of (2.81~4.40)%/min

(1.50~2.14)%/min and (1.77~2.41)%/min

respectively. ②Bland-Altman analysis showed that the mean difference of EGOS-600 and BRS-1 to INVOS 5100C were 5.7 and 2.5 respectively. Deming regression displayed that the Person coefficient was 0.722 4 and 0.845 9

respectively (

0.001)

which were in good consistency and correlation with INVOS 5100C. ③In terms

of absolute values of 10%

20% and 50% relative reduction in INVOS 5100C as the key interventional rSO

thresholds

EGOS-600 detection rates were 90%

48% and 40% and BRS-1 detection rates were 80%

48% and 50%. ④The ROC curve results indicated the AUC value was 0.893 and 0.715 for EGOS-600 and BRS-1

respectively

and the cut-off threshold for hypoxia prediction was 59.3% and 56.0%

respectively.

Conclusion

The response of EGOS-600 and BRS-1 to oxygenation changes is similar to that of INVOS 5100C

and the correlation and consistency are good

which can accurately predict brain oxygen changes.

关键词

Keywords

references

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