Impact of diltiazem/beprost on exercise endurance in healthy young males after high altitude exposure

Xiangjun LI; Xiuliang WANG; Fangzhou LIU; Liang ZHOU; Lunwei ZHANG; Jun LI; Fengqin MA; Xuehui BU; Ni CHANG

doi:10.16016/j.2097-0927.202208132

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Impact of diltiazem/beprost on exercise endurance in healthy young males after high altitude exposure

Military Medicine | 更新时间：2026-01-09

- Impact of diltiazem/beprost on exercise endurance in healthy young males after high altitude exposure
- Journal of Army Medical University Vol. 45, Issue 6, Pages: 480-485(2023)
- 作者机构：
  
  816099 青海格尔木，陆军第952医院心血管呼吸内科
- 作者简介：
- 基金信息：
  
  the Youth Training Program of Military Medical Science and Technology(15QNP095)
- DOI：10.16016/j.2097-0927.202208132
  CLC： R339.4;R339.54;R969.4
- Received：18 August 2022，
  
  Revised：2022-09-19，
  
  Published：30 March 2023
- 稿件说明：
移动端阅览
Xiangjun LI, Xiuliang WANG, Fangzhou LIU, et al. Impact of diltiazem/beprost on exercise endurance in healthy young males after high altitude exposure[J]. Journal of Army Medical University, 2023, 45(6): 480-485.
DOI：

Xiangjun LI, Xiuliang WANG, Fangzhou LIU, et al. Impact of diltiazem/beprost on exercise endurance in healthy young males after high altitude exposure[J]. Journal of Army Medical University, 2023, 45(6): 480-485. DOI： 10.16016/j.2097-0927.202208132.

摘要

目的

探讨单用或联合使用地尔硫卓、贝前列素对提高健康青年男性高原暴露后运动耐力的有效性及安全性。

方法

从2017年7月至2020年8月共纳入200例世居平原非藏族健康青年男性作为研究对象，从平原进驻高原(海拔2 815 m)后随机分为4组，A组: 口服地尔硫卓缓释胶囊安慰剂90 mg，1次/d；贝前列素安慰剂40 μg，3次/d。B组: 口服地尔硫卓缓释胶囊安慰剂90 mg，1次/d；贝前列素40 μg，3次/d。C组: 口服地尔硫卓缓释胶囊90 mg，1次/d；贝前列素安慰剂40 μg，3次/d。D组: 口服地尔硫卓缓释胶囊90 mg，1次/d；贝前列素40 μg，3次/d。连续干预5 d后，对比干预前后6分钟步行距离(6 minute walk distance，6MWD)及脉搏血氧饱和度(pulse oxygen saturation，SpO

)、血压(blood pressure，BP)、肺动脉收缩压(pulmonary artery systolic pressure，PASP)与不良反应等指标。

结果

13例失访，最终187例纳入数据统计。干预后B、C、D组6MWD均显著提高(

=-9.048、-9.555、-12.903，95%

: -45.582~-28.984、-46.391~-30.262、-63.205~-46.128，

＜0.05)；B、C、D组PASP均显著降低(

=10.219、9.380、11.069，95%

: 2.304~3.435、2.277~3.519、2.636~3.809，

＜0.05)；C、D组SpO

显著升高(

=-4.071、-4.655，95%

: -1.311~-0.444、-2.569~-1.031，

＜0.05)。干预后各组间比较，B、C、D组6MWD均较A组显著提高(

=7.246，

＜0.05)；PASP均较A组显著降低(

=10.421，

＜0.05)；D组SpO

较A、B、C组显著升高(

=6.896，

＜0.05)。BP、不良反应均无显著性差异。

结论

单用或联合使用地尔硫卓、贝前列素均能提升健康青年男性高原暴露后运动耐力，安全性较好。

Abstract

Objective

To investigate the efficacy and safety of single or combined use of diltiazem and beprost on exercise endurance improvement after high altitude exposure in healthy young males.

Methods

A total of 200 non-Tibet health young men who have inhabited in plain areas for generations and were transferred from plain to plateau (2 815 m) from July 2017 to August 2020 were recruited in the study. The participants were randomly assigned in group A (90 mg diltiazem sustained-release capsule placebo once a day and 40 μg beraprost placebo 3 times a day)

B (90 mg diltiazem sustained-release capsule placebo once a day and 40 μg beraprost 3 times a day). C (90 mg diltiazem sustained-release capsules once a day and 40 μg beraprost placebo 3 times a day) and D (90 mg diltiazem sustained-release capsules once a day and 40 μg beraprost 3 times a day). After 5 days' continuous administration of drug and placebo

results of 6-minute walk distance (6MWD) test

pulse oxygen saturation (SpO

)

blood pressure (BP) and pulmonary artery systolic pressure (PASP)

and incidence of adverse reactions before and after intervention were collected and compared among the groups.

Results

There were 13 cases lost during follow-up

and finally 187 participants were included. After intervention

the results of 6MWD test were obviously improved (

=-9.048

-9.555

-12.903

95%

: -45.582~-28.984

-46.391~-30.262

-63.205~-46.128

0.05)

PASP values (

=10.219

9.380

11.069

95%

: 2.304~3.435

2.277~3.519

2.636~3.809

0.05) were significantly decreased in group B

group C and group D

and the SpO

values (

=-4.071

-4.655

95%

: -1.311~-0.444

-2.569~-1.031

0.05) were greatly increased in groups C and D. In addition

the participants from the groups B

C and D obtained significantly prolonged 6MWD results (

=7.246

0.05) and lower PASP value (

=10.421

0.05) after the treatment when compared with those of group A. Moreove

SpO

in group D was significantly higher than that in groups A

B and C (

=6.896

0.05). There were no significant difference in BP value and incidence of adverse reactions.

Conclusion

Single or combined use of diltiazem and beprost can improve exercise endurance in healthy young males after high altitude exposure

with good safety.

关键词

Keywords

references

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